RecruitingNot ApplicableNCT05229666

Stress Phenotypes and Preterm Birth

Stress Phenotypes and Preterm Birth: Immune and Energetic Cellular Dysregulation and the Preventive Effect of Social Support

Sponsor

Columbia University

Enrollment

200 participants

Start Date

Dec 9, 2021

Study Type

INTERVENTIONAL

Conditions

Stress Mental Health Issue Inflammation Preterm Birth

Summary

Pregnancy ends in preterm birth (PTB) for approximately 1 in 10 women, though more often for Non-Hispanic Black women, 14.12% PTB rate, compared to 9.09% for Non-Hispanic White women. Psychosocial stress and childhood trauma each are associated with risk for PTB and PTB has an intergenerational impact: mothers born preterm are more likely to give birth preterm, especially amongst Black women. In this project, we will study mitochondria, which contain their own genome, the mitochondria DNA, and are inherited from the mother, as they represent a potential intersection point between psychosocial experiences and their biological embedding in underlying disease outcomes such as PTB

Eligibility

Sex: FEMALEMin Age: 18 Years

Inclusion Criteria4

Pregnant women 18 years of age or older (based on self-report)
Not currently smoking, drinking alcohol, or taking drugs (based on self-report)
Planning to deliver at CUIMC/NYP (based on self-report)
In the first or second trimester of pregnancy (prior to 28 weeks gestation) (based on self-report of estimated date of delivery)

Exclusion Criteria4

Multi-fetal pregnancy (based on self-report)
Taking medications regularly that affect the cardiovascular and inflammatory systems, including NSAIDS and other anti-inflammatories, α blockers, β blockers, corticosteroids, chronic-use asthma medications (e.g. beta2- adrenoceptor agonists) (based on self-report)
This does NOT include baby aspirin or low-dose aspirin, as baby aspirin / low-dose aspirin is not normally considered to be an NSAID.
Inflammatory conditions including rheumatoid arthritis, lupus, and multiple sclerosis (based on self-report)

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