Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training
The Cleveland Clinic
52 participants
Dec 9, 2025
INTERVENTIONAL
Conditions
Summary
A research study to assess the baseline olfactory function, mental health status, clinical severity, and immunological profile in patients with smell loss. The impact of a 3-month olfactory training program on smell function, immunological changes, and mental health in patients with smell loss will be evaluated. The primary purpose of this study is to investigate tissue and blood samples to identify molecules that may be related to smell loss, ultimately aiming to develop future treatments for this condition and correlate with cognition.
Eligibility
Inclusion Criteria3
- Age less than 18 years-old
- Present to rhinology clinic with CRS with nasal polyps
- Sense of smell loss for any reason (other than trauma or tumor)
Exclusion Criteria6
- Patients < 18 years of age
- Individuals with unilateral nasal polyps
- Autoimmune diseases
- Ciliary disorders
- Cystic fibrosis
- Smell loss due to tumors or trauma
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Interventions
Patients experiencing loss of smell from chronic rhinosinusitis (CRS)will undergo smell training.
Locations(1)
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NCT07681973