Dietary Fiber to Induce Gut Microbiota-mediated Response to Immunotherapy in Melanoma.
Radboud University Medical Center
70 participants
Jul 31, 2026
INTERVENTIONAL
Conditions
Summary
Previous research has shown that a higher fiber intake may have a beneficial effect on the intestinal health and improve the effectiveness of immunotherapy, but this is not certain. The objective of this double-blinded randomized clinical trial is to analyze, whether increased dietary fiber intake by patients with metastatic melanoma will increase the relative amount of Bifidobacterium, which in turn stimulates immune cell activity and improves the response to immunotherapy.
Eligibility
Plain Language Summary
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Interventions
The dried chicory roots are implemented using a dosage of 22.5 gram/day resulting in 18.5 gram additional fibers a day.
The control arm will receive 12.4 grams of placebo a day, isocaloric to the intervention.
Locations(2)
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NCT07686835