Phase 1 Adult Clinical Trials
231 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 231 trials
Recruiting
Phase 1Phase 2
A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression
Colorectal, CancerOvarian CancerLung Cancer+17 more
A2 Biotherapeutics Inc.474 enrolled12 locationsNCT06051695
Recruiting
Phase 1
Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma
Astrocytoma, IDH-Mutant, Grade 2Recurrent Adult Diffuse Hemispheric Glioma, H3 G34-MutantRecurrent Adult Diffuse Midline Glioma, H3 K27-Mutant+4 more
National Cancer Institute (NCI)30 enrolled42 locationsNCT06860594
Recruiting
Phase 1
A Vaccine (VSV-hIFNβ-NIS) With or Without Cyclophosphamide and Combinations of Ipilimumab, Nivolumab, and Cemiplimab in Treating Relapsed or Refractory Multiple Myeloma, Acute Myeloid Leukemia or Lymphoma
Myelodysplastic SyndromeB-cell Non Hodgkin LymphomaRefractory Acute Myeloid Leukemia+16 more
Mayo Clinic99 enrolled2 locationsNCT03017820
Recruiting
Phase 1
A Study of NHL907 in Healthy Adult Participants
healthy adult participants
NeuHyll AUS Pty Ltd64 enrolled1 locationNCT07580924
Recruiting
Phase 1Phase 2
GPC3-Targeted T-Cell Therapy (ECT204) in Adults With Advanced HCC
Hepatocellular CarcinomaMetastatic Liver CancerLiver Cancer, Adult+1 more
Eureka Therapeutics Inc.60 enrolled8 locationsNCT04864054
Recruiting
Phase 1
A Study to Exploratively Evaluate the Safety, Tolerability and Pharmacokinetics of DA-5223 Compared With DA-5223-R in Healthy Adult Subjects
Healthy Adult
Dong-A ST Co., Ltd.12 enrolled1 locationNCT07633691
Recruiting
Phase 1Phase 2
First-in-human Study of DB-1419 for Advanced/Metastatic Solid Tumors
Solid Tumor, Adult
DualityBio Inc.360 enrolled36 locationsNCT06554795
Recruiting
Phase 1
A Study of Psychedelics in Healthy Older Adults With Low Well-being
Older Adults (50-90 Years)Anhedonia in Healthy Volunteers
Jennifer Mitchell80 enrolled1 locationNCT07386730
Recruiting
Phase 1
A Study of Mutant Selective-Inhibitor (CGT6297), in Patients With Advanced Solid Tumors
Endometrial CancerHER2-low Breast CancerHR Positive/HER-2 Negative Breast Cancer+2 more
Cogent Biosciences, Inc.90 enrolled2 locationsNCT07383506
Recruiting
Phase 1
A Trial to Compare the Pharmacokinetics of Two Presentations of Navenibart in Healthy Participants
healthy adult participants
Astria Therapeutics, Inc.180 enrolled3 locationsNCT07635095
Recruiting
Phase 1Phase 2
First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors
Breast CancerSolid Tumors, Adult
Eli Lilly and Company880 enrolled65 locationsNCT05768139
Recruiting
Phase 1
Imaging of Solid Tumors Using FAP-2286
Metastatic CancerSolid Tumors, Adult
Thomas Hope191 enrolled1 locationNCT04621435
Recruiting
Phase 1
BBO-11818 in Adult Subjects With KRAS Mutant Cancer
Non-small Cell Lung CancerNSCLCMetastatic Pancreatic Ductal Adenocarcinoma+11 more
TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)665 enrolled17 locationsNCT06917079
Recruiting
Phase 1Phase 2
Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM
CancerBrain TumorBrain Cancer+6 more
Northwell Health67 enrolled1 locationNCT03213002
Recruiting
Phase 1
Study of LGW16-03 To Identify Nerves
AdultsOpen-field SurgeryMajor Nerve
Eric R. Henderson38 enrolled1 locationNCT07385430
Recruiting
Phase 1
Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
Endometrial CancerColorectal CarcinomaNon-small Cell Lung Cancer+3 more
AstraZeneca108 enrolled18 locationsNCT06218914
Recruiting
Phase 1Phase 2
A Study to Determine the Effect of CT3001 in Patients With Advanced Solid Tumors
Colorectal, CancerPancreatic Ductal AdenocarcinomaSolid Tumor, Adult
Crossignal Therapeutics, Inc.78 enrolled1 locationNCT06598007
Recruiting
Phase 1Phase 2
Combination of Tarlatamab and Temozolomide in Patients With Central Nervous System Tumors
GliomaCNS Tumor, AdultCNS Tumor, Childhood
Centre Leon Berard70 enrolled12 locationsNCT07243470
Recruiting
Phase 1Phase 2
A Phase Ⅰ/Ⅱa Study of HMPL-A251 in Participants With Advanced or Metastatic HER2-expressing Solid Tumors
Solid Tumors, Adult
Hutchmed147 enrolled16 locationsNCT07228247
Recruiting
Phase 1Phase 2
A Study of ATTR-01 in Participants With Select Epithelial Solid Tumours
Solid Tumor, Adult
Accession Therapeutics Limited72 enrolled8 locationsNCT06977737