Phase 1 Adult Clinical Trials
196 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 196 trials
Recruiting
Phase 1
Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
Endometrial CancerColorectal CarcinomaNon-small Cell Lung Cancer+3 more
AstraZeneca108 enrolled18 locationsNCT06218914
Recruiting
Phase 1
A Study of SYNT-101 to Test Safety, Tolerability and Pharmacodynamics of SYNT-101 in Healthy and Overweight Adults
HealthyOverweight and Obese Adults
Syntis Bio64 enrolled1 locationNCT07307274
Recruiting
Phase 1Phase 2
A Phase I/II Study of OJP-001 in Patients With Adult T-cell Leukemia/Lymphoma
Adult T-Cell Leukemia/Lymphoma (ATLL)
Otsuka Medical Devices Co., Ltd. Japan49 enrolled5 locationsNCT07075328
Recruiting
Phase 1Phase 2
Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
Hypoxia, BrainBlood PressureStroke+5 more
University of Calgary12 enrolled1 locationNCT03255408
Recruiting
Phase 1
Single-ascending Dose Study of HEC-151 Injection
Healthy Adult Male
Sunshine Lake Pharma Co., Ltd.81 enrolled2 locationsNCT07376200
Recruiting
Phase 1
A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)
High Grade GliomaAdult GlioblastomaWHO Grade III or IV Malignant Glioma
University of Florida28 enrolled1 locationNCT04573140
Recruiting
Phase 1Phase 2
GT201 Injection For The Treatment Of Advanced Solid Tumors
Solid Tumor, Adult
Grit Biotechnology18 enrolled4 locationsNCT06144671
Recruiting
Phase 1Phase 2
Combination of Tarlatamab and Temozolomide in Patients With Central Nervous System Tumors
GliomaCNS Tumor, AdultCNS Tumor, Childhood
Centre Leon Berard70 enrolled11 locationsNCT07243470
Recruiting
Phase 1Phase 2
First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors
Breast CancerSolid Tumors, Adult
Eli Lilly and Company880 enrolled66 locationsNCT05768139
Recruiting
Phase 1
Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery
Brain Metastases, AdultBrain MetastasesBrain Cancer
Baptist Health South Florida20 enrolled1 locationNCT04689048
Recruiting
Phase 1
A Study to Evaluate the Effect of Food on the Bioavailability of AJ201, and Safety, Tolerability, and Pharmacokinetics of AJ201 in Japanese and White Healthy Male Participants
Food Effect in Healthy VolunteersHealthy Male Adults
AnnJi Pharmaceutical Co., Ltd.26 enrolled1 locationNCT07549919
Recruiting
Phase 1
A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors
Ovarian CancerOvarian CarcinomaAdvanced Solid Tumor+8 more
NiKang Therapeutics, Inc.150 enrolled19 locationsNCT06586957
Recruiting
Phase 1Phase 2
Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated Ca
Solid Tumor, Adult
Virginia Commonwealth University83 enrolled1 locationNCT03919292
Recruiting
Phase 1
A Study of JPH034 in Healthy Adult Participants
Health Adult Subjects
J-Pharma Co., Ltd.40 enrolled1 locationNCT07534657
Recruiting
Phase 1Phase 2
Retifanlimab (Anti-PD-1 Antibody) With Gemcitabine and Docetaxel in Patients With Advanced Soft Tissue Sarcoma
Soft Tissue SarcomaSarcomaSarcoma,Soft Tissue+1 more
Memorial Sloan Kettering Cancer Center98 enrolled1 locationNCT04577014
Recruiting
Phase 1Phase 2
A Study of BI-1206 in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors
Solid Tumor, Adult
BioInvent International AB197 enrolled25 locationsNCT04219254
Recruiting
Phase 1
IB-T101 Injection for Treatment of Patients With Advanced Clear Cell Renal Cell Carcinoma
AdultAdvanced Clear Renal Cell Carcinoma
Grit Biotechnology12 enrolled1 locationNCT06819293
Recruiting
Phase 1
GT101 Injection for the Treatment of Metastatic or Recurrent Solid Tumors
Solid Tumors, Adult
Grit Biotechnology31 enrolled5 locationsNCT05430373
Recruiting
Phase 1
A Clinical Study of GenSci134 in Healthy Adults and Adult Growth Hormone Deficiency(AGHD)
SafetyTolerabilityAdult Growth Hormone Deficiency
Changchun GeneScience Pharmaceutical Co., Ltd.64 enrolled1 locationNCT07016802
Recruiting
Phase 1Phase 2
ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors
CancerSolid Tumor, AdultRefractory Cancer+1 more
Immatics US, Inc.375 enrolled21 locationsNCT03686124