Phase 2 Advanced Hepatocellular Carcinoma Clinical Trials
26 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 26 trials
Recruiting
Phase 1Phase 2
Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.
Hepatocellular CarcinomaMetastatic Hepatocellular CarcinomaUnresectable Hepatocellular Carcinoma+4 more
Pfizer138 enrolled11 locationsNCT07227012
Recruiting
Phase 2
At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer
Advanced Colorectal CarcinomaAdvanced Anal CarcinomaAdvanced Biliary Tract Carcinoma+41 more
Mayo Clinic220 enrolled2 locationsNCT05969860
Recruiting
Phase 1Phase 2
Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE Trial
Metastatic Hepatocellular CarcinomaStage III Hepatocellular Carcinoma AJCC v8Stage IV Hepatocellular Carcinoma AJCC v8+1 more
National Cancer Institute (NCI)92 enrolled4 locationsNCT06811116
Recruiting
Phase 2
HAI or IV of Adebrelimab, Combined With Bevacizumab and HAI of FOLFOX for Advanced Unresectable Hepatocellular Carcinoma
Advanced Hepatocellular Carcinoma (HCC)
Sun Yat-sen University76 enrolled1 locationNCT06737913
Recruiting
Phase 1Phase 2
Dual-Target GPC3/B7-H3 CAR-NK Cells for Advanced HCC
Metastatic Liver CancerAdvanced Hepatocellular Carcinoma (HCC)
Beijing Biotech30 enrolled1 locationNCT07500220
Recruiting
Phase 2
Phase 2 Study of WGI-0301 for Advanced HCC
Advanced Hepatocellular Carcinoma (HCC)
Zhejiang Haichang Biotech Co., Ltd.60 enrolled4 locationsNCT06309485
Recruiting
Phase 1Phase 2
Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors
Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Metastatic Triple-Negative Breast Carcinoma+97 more
Mayo Clinic132 enrolled1 locationNCT05269381
Recruiting
Phase 2
Ligufalimab and Cadonilimab in Advanced Liver Cancers
Biliary Tract CancerAdvanced Hepatocellular CarcinomaRefractory Hepatocellular Carcinoma
University of Texas Southwestern Medical Center64 enrolled1 locationNCT06789848
Recruiting
Phase 2
Celecoxib, Durvalumab and Tremelimumab for the Treatment of Patients With Advanced or Metastatic Liver Cancer
Metastatic Hepatocellular CarcinomaStage III Hepatocellular Carcinoma AJCC v8Stage IV Hepatocellular Carcinoma AJCC v8+1 more
Emory University39 enrolled4 locationsNCT07174570
Recruiting
Phase 2
Olanzapine for the Management of Cancer Associated Appetite Loss in Patients With Advanced Esophagogastric, Hepatopancreaticobiliary, Colorectal or Lung Cancer
Locally Advanced Hepatocellular CarcinomaLocally Advanced Gastric CarcinomaAdvanced Biliary Tract Carcinoma+7 more
OHSU Knight Cancer Institute66 enrolled1 locationNCT05705492
Recruiting
Phase 2
A Study Comparing Immunotherapy Alone Versus Immunotherapy Combined With Radiotherapy in Patients With Hepatocellular Carcinoma (HCC) With Vascular Invasion
Advanced Hepatocellular Carcinoma (HCC)
National Cancer Center, Korea128 enrolled2 locationsNCT06828380
Recruiting
Phase 2
Durvalumab With/Without Tremelimumab After Palliative Hypofractionated Radiotherapy for Hepatocellular Carcinoma
Stage III Hepatocellular Carcinoma AJCC v8Stage IIIA Hepatocellular Carcinoma AJCC v8Stage IIIB Hepatocellular Carcinoma AJCC v8+4 more
Mary Feng, MD21 enrolled1 locationNCT04430452
Recruiting
Phase 2
Multinational Phase II Trial to Compare Safety and Efficacy of SIRT (Y-90 Resin Microspheres) Followed by Atezolizumab Plus Bevacizumab, vs SIRT (SIRT-Y90) Followed by Placebo in Locally Advanced HCC Patients
Locally Advanced Hepatocellular Carcinoma
National Cancer Centre, Singapore100 enrolled14 locationsNCT05377034
Recruiting
Phase 2
Atezolizumab in Combination With a Multi-Kinase Inhibitor for the Treatment of Unresectable, Locally Advanced, or Metastatic Liver Cancer
Locally Advanced Hepatocellular CarcinomaMetastatic Hepatocellular CarcinomaStage III Hepatocellular Carcinoma AJCC v8+6 more
Academic and Community Cancer Research United122 enrolled16 locationsNCT05168163
Recruiting
Phase 1Phase 2
A Clinical Study of Multi-target Hi-TCR-T Cells in the Treatment of Advanced Hepatocellular Carcinoma
Advanced Hepatocellular Carcinoma (HCC)
Eastern Hepatobiliary Surgery Hospital30 enrolled1 locationNCT06902389
Recruiting
Phase 2
A Study of BL-B01D1 Combined With Lenvatinib in Patients With Advanced Hepatocellular Carcinoma
Advanced Hepatocellular Carcinoma
Sichuan Baili Pharmaceutical Co., Ltd.46 enrolled1 locationNCT06986785
Recruiting
Phase 1Phase 2
Autologous Neoantigen-Specific T-Cell Therapy for Advanced Hepatocellular Carcinoma
Advanced Hepatocellular Carcinoma (HCC)
Zhejiang University20 enrolled1 locationNCT07123545
Recruiting
Phase 1Phase 2
A Study of Tegavivint (BC2059) in Patients With Advanced Hepatocellular Carcinoma
Advanced Hepatocellular Carcinoma
Iterion Therapeutics178 enrolled8 locationsNCT05797805
Recruiting
Phase 1Phase 2
Personalized Tumor Neoantigen mRNA Therapy for Advanced Hepatocellular Carcinoma
Advanced Hepatocellular Carcinoma (HCC)
Zhejiang University30 enrolled1 locationNCT06995105
Recruiting
Phase 2
Cryoablation Combined with Tislelizumab Plus Lenvatinib As Second-line or Later Therapy in Advanced Hepatocellular Carcinoma
Advanced Hepatocellular Carcinoma
Fudan University25 enrolled1 locationNCT05057845