Phase 1 ALS Clinical Trials
18 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–18 of 18 trials
Recruiting
Phase 1Phase 2
Examining a Novel Gastrointestinal Intervention to Negate Environmental Toxicants (ENGINE)
Toxicant ExposureFirefighterOccupational Exposure to Chemicals
University of California, San Francisco50 enrolled1 locationNCT07226440
Recruiting
Phase 1
AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis
ALS
Amylyx Pharmaceuticals Inc.48 enrolled14 locationsNCT06665165
Recruiting
Phase 1
A Study of TCD601 (Siplizumab) in Newly Diagnosed Adult Amyotrophic Lateral Sclerosis (ALS) Patients
ALS
ITB-Med LLC48 enrolled3 locationsNCT06453668
Recruiting
Phase 1
A Study of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis
ALS (Amyotrophic Lateral Sclerosis)
Eli Lilly and Company32 enrolled12 locationsNCT07100119
Recruiting
Phase 1
The Efficacy and Safety Study of CAR-T Cells for Functional Cure in HIV-1/AIDS Patients
HIVHIV Infected Individuals
Institute of Hematology & Blood Diseases Hospital, China3 enrolled1 locationNCT06880380
Recruiting
Phase 1
Augmenting Ankle Plantarflexor Function in Cerebral Palsy
Cerebral Palsy
Northern Arizona University36 enrolled1 locationNCT05154253
Recruiting
Phase 1
Safety and Tolerability Study of CTx1000 In Participants With Amyotrophic Lateral Sclerosis
ALS (Amyotrophic Lateral Sclerosis)
Celosia Therapeutics Pty Ltd15 enrolled1 locationNCT07401121
Recruiting
Phase 1
Safety and Early Efficacy of iPSC-Derived Motor Neuron Progenitor Cells (XS228) in Subacute Spinal Cord Injury: A Phase I Trial
EfficacySafetySpinal Cord Injury+4 more
XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.12 enrolled1 locationNCT06976229
Recruiting
Phase 1
Intravenous Immunoglobulin (IVIG) and Blood-Brain Barrier Disruption in Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral SclerosisALS
Sunnybrook Health Sciences Centre6 enrolled1 locationNCT07193953
Recruiting
Phase 1Phase 2
Efficacy of Prednisolone Versus Cerebrolysin in the Treatment of Bell's Palsy
Bell Palsy
October 6 University90 enrolled1 locationNCT05821075
Recruiting
Phase 1
Pharmacogenomic Contributions to Trihexyphenidyl Biotransformation and Response in Children With Dystonic Cerebral Palsy
Genetic PredispositionDystoniaPediatric Disorder+5 more
Children's Mercy Hospital Kansas City40 enrolled1 locationNCT06554288
Recruiting
Phase 1
Effects of Peripheral Magnetic Stimulation on Cortical Excitability in Healthy Individuals
Healthy Individuals
Universidade Federal de Pernambuco18 enrolled1 locationNCT07025759
Recruiting
Phase 1
Effects of Trans-spinal Magnetic Stimulation on Cortical Excitability in Healthy Individuals
Healthy Individuals
Universidade Federal de Pernambuco18 enrolled1 locationNCT07026760
Recruiting
Phase 1
Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intravenous Infusion for CP
Cerebral Palsy
The Foundation for Orthopaedics and Regenerative Medicine15 enrolled2 locationsNCT05018819
Terminated
Phase 1
A 15-Day, Single-blind, Placebo Controlled Food Safety and Tolerability Study of AXA3359 in Adult Subjects with Mild Traumatic Brain Injury (mTBI)
Otherwise healthy individuals with mild Traumatic Brain InjuryConcussion
Axcella Health Inc.30 enrolled1 locationACTRN12618001341213
Completed
Phase 1
Determination of the Blood Pharmacodynamic Effects following a Single Dose of Oral Anatabine Citrate in Normal Healthy Volunteers
Pharmacodynamic effects study conducted in healthy volunteers with no health condition or problem studied.
This study is being conducted in healthy volunteers who are not being treated for the conditions that anatabine citrate are indicated for. Anatabine citrate is a naturally occurring alkaloid found in the Solanaceae plant family. It is also the ingredient of a number of dietary supplements.
Zenith Technology Corp Ltd10 enrolled1 locationACTRN12615000098538
Terminated
Phase 1
A Phase 1, Randomized, Double-Blind, Placebo-Controlled Trial to Investigate the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of Oral ACH-0143422 after Single and Multiple-ascending Doses in Health Volunteers and Subjects With Chronic Hepatitis C Virus Genotype 1 Infection.
This current study is being conducted in healthy volunteers to learn about the way this drug behaves in the body when it is given at different doses. The study will also be conducted in patients with Hepatitis C genotype 1.
Achillion Pharmaceuticals, Inc157 enrolled1 locationACTRN12614000304639
Completed
Phase 1
Activity and Safety of SCH 532706 in HIV-1 Infected Subjects
CCR5-tropic HIV-Infected Individuals
Schering-Plough12 enrolled1 locationACTRN12607000171415