Phase 1 ALS Clinical Trials
27 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 27 trials
Recruiting
Phase 1
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
DementiaALSMild Cognitive Impairment+2 more
National Institute of Mental Health (NIMH)184 enrolled1 locationNCT04396873
Recruiting
Phase 1Phase 2
A Clinical Trial to Evaluate NB-4746 in Participants With Amyotrophic Lateral Sclerosis.
Amyotrophic Lateral Sclerosis(ALS)
Nura Bio80 enrolled6 locationsNCT07369076
Recruiting
Phase 1Phase 2
Examining a Novel Gastrointestinal Intervention to Negate Environmental Toxicants (ENGINE)
Toxicant ExposureFirefighterOccupational Exposure to Chemicals
University of California, San Francisco50 enrolled1 locationNCT07226440
Recruiting
Phase 1Phase 2
Intestinal Microbiome Transplant in ALS
Amyotrophic Lateral Sclerosis(ALS)
Duke University20 enrolled1 locationNCT07017946
Recruiting
Phase 1
AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis
ALS
Amylyx Pharmaceuticals Inc.48 enrolled14 locationsNCT06665165
Not Yet Recruiting
Phase 1
A study to assess safety, tolerability and pharmacokinetics of RTX-010/101/111 for participants with C9orf72-mediated Amyotrophic Lateral Sclerosis (ALS). Part 1C adults with C9orf72-mediated ALS only.
C9orf72-mediated Amyotrophic Lateral Sclerosis (ALS)
Repeat Therapeutics Pty Ltd16 enrolled1 locationACTRN12626000385347
Recruiting
Phase 1
A Study of TCD601 (Siplizumab) in Newly Diagnosed Adult Amyotrophic Lateral Sclerosis (ALS) Patients
ALS
ITB-Med LLC48 enrolled3 locationsNCT06453668
Recruiting
Phase 1
A Study of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis
ALS (Amyotrophic Lateral Sclerosis)
Eli Lilly and Company32 enrolled12 locationsNCT07100119
Recruiting
Phase 1
The Efficacy and Safety Study of CAR-T Cells for Functional Cure in HIV-1/AIDS Patients
HIVHIV Infected Individuals
Institute of Hematology & Blood Diseases Hospital, China3 enrolled1 locationNCT06880380
Recruiting
Phase 1
Augmenting Ankle Plantarflexor Function in Cerebral Palsy
Cerebral Palsy
Northern Arizona University36 enrolled1 locationNCT05154253
Recruiting
Phase 1Phase 2
First in Human (FIH) Study of ALN-SOD in Adult Participants With Amyotrophic Lateral Sclerosis Associated With Mutation in the SOD1 Gene (SOD1-ALS)
Amyotrophic Lateral Sclerosis(ALS)Mutation in the Superoxide Dismutase-1 (SOD1) Gene
Regeneron Pharmaceuticals42 enrolled16 locationsNCT06351592
Recruiting
Phase 1
Safety and Tolerability Study of CTx1000 In Participants With Amyotrophic Lateral Sclerosis
ALS (Amyotrophic Lateral Sclerosis)
Celosia Therapeutics Pty Ltd15 enrolled1 locationNCT07401121
Recruiting
Phase 1
Safety and Early Efficacy of iPSC-Derived Motor Neuron Progenitor Cells (XS228) in Subacute Spinal Cord Injury: A Phase I Trial
EfficacySafetySpinal Cord Injury+4 more
XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.12 enrolled1 locationNCT06976229
Recruiting
Phase 1
The Safety, Tolerability and Preliminary Efficacy of Derived Motor Neuron Progenitor Cells (XS228CN) in Subjects With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis(ALS)
XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.12 enrolled1 locationNCT07118319
Recruiting
Phase 1
Clinical Study of Regulatory T Cells (Tregs) in the Treatment of Neurodegenerative Diseases
Amyotrophic Lateral Sclerosis(ALS)
Novabio Therapeutics12 enrolled1 locationNCT06671236
Recruiting
Phase 1
Intravenous Immunoglobulin (IVIG) and Blood-Brain Barrier Disruption in Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral SclerosisALS
Sunnybrook Health Sciences Centre6 enrolled1 locationNCT07193953
Recruiting
Phase 1Phase 2
Efficacy of Prednisolone Versus Cerebrolysin in the Treatment of Bell's Palsy
Bell Palsy
October 6 University90 enrolled1 locationNCT05821075
Recruiting
Phase 1
Pharmacogenomic Contributions to Trihexyphenidyl Biotransformation and Response in Children With Dystonic Cerebral Palsy
Genetic PredispositionDystoniaPediatric Disorder+5 more
Children's Mercy Hospital Kansas City40 enrolled1 locationNCT06554288
Recruiting
Phase 1
Effects of Peripheral Magnetic Stimulation on Cortical Excitability in Healthy Individuals
Healthy Individuals
Universidade Federal de Pernambuco18 enrolled1 locationNCT07025759
Recruiting
Phase 1
Effects of Trans-spinal Magnetic Stimulation on Cortical Excitability in Healthy Individuals
Healthy Individuals
Universidade Federal de Pernambuco18 enrolled1 locationNCT07026760