Anterior cruciate ligament Clinical Trials

127 recruitingLast updated: July 25, 2026

There are 127 actively recruiting anterior cruciate ligament clinical trials across 36 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1, Early Phase 1. Top locations include Ankara, Turkey (Türkiye), Chapel Hill, North Carolina, United States, Beijing, China. Updated daily from ClinicalTrials.gov.


Anterior cruciate ligament Trials at a Glance

127 actively recruiting trials for anterior cruciate ligament are listed on ClinicalTrialsFinder across 6 cities in 36 countries. The largest study group is Not Applicable with 79 trials, with the heaviest enrollment activity in Ankara, Chapel Hill, and Beijing. Lead sponsors running anterior cruciate ligament studies include Peking University Third Hospital, University of North Carolina, Chapel Hill, and Cairo University.

Browse anterior cruciate ligament trials by phase

Treatments under study

About Anterior cruciate ligament Clinical Trials

Looking for clinical trials for Anterior cruciate ligament? There are currently 5 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Anterior cruciate ligament trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Anterior cruciate ligament clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 127 trials

Recruiting
Not Applicable

Tourniquet vs. Dual-flow Arthroscopy Sheath in Anterior Cruciate Ligament (ACL) Reconstruction

Anterior cruciate ligament reconstruction
Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer128 enrolled3 locationsNCT06819696
Recruiting
Not Applicable

Gait Rehabilitation to Treat FastOA

Knee injuriesKnee OsteoarthritisOsteo Arthritis Knee+4 more
University of North Carolina, Chapel Hill70 enrolled1 locationNCT05848622
Recruiting
Not Applicable

Quadriceps Tendon vs Peroneus Longus Tendon in ACL Reconstruction

Anterior cruciate ligament injuryAnterior cruciate ligament rupture
Acibadem University60 enrolled1 locationNCT07671729
Recruiting
Phase 2

Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery

Hip arthroscopyTotal Hip Arthroplasty (THA)Total Knee Arthroplasty+1 more
Rush University Medical Center240 enrolled1 locationNCT07020312
Recruiting
Not Applicable

Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT

Orthopedic DisorderAnterior Cruciate Ligament Injuries
University of Alabama at Birmingham100 enrolled1 locationNCT05461326
Recruiting

Augmented Reality in Surgery

Anterior Cruciate Ligament (ACL) Tear
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio100 enrolled1 locationNCT07636278
Recruiting
Not Applicable

Robotic Assistance for Tunnel Positioning in Anterior Cruciate Ligament Reconstruction

Anterior Cruciate Ligament Injuries
Centre Hospitalier Universitaire, Amiens30 enrolled1 locationNCT04183803
Recruiting
Not Applicable

Prospective Evaluation of Silk Fibroin Incision Dressings in ACL Reconstruction

Anterior cruciate ligament reconstruction
NYU Langone Health100 enrolled1 locationNCT07217613
Recruiting
Not Applicable

Cross Bracing Protocol Versus Surgery for Acute Anterior Cruciate Ligament Rupture

Anterior cruciate ligament rupture
University of Melbourne180 enrolled1 locationNCT06956339
Recruiting
Not Applicable

Determining the Effects of Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After ACL Reconstruction

Anterior Cruciate Ligament Reconstruction RehabilitationQuadriceps Muscle Function
Arcadia University42 enrolled1 locationNCT07128602
Recruiting
Not Applicable

Analysis Of Knee Joint Of Patients With Anterior Cruciate Ligament Injury Undergoing Physiotherapy After Two Different Surgical Techniques: A Randomized Clinical Trial.

Anterior Cruciate Ligament (ACL) TearAnterior Cruciate Ligament Reconstruction Rehabilitation
Universidade Estadual de Londrina20 enrolled3 locationsNCT06809920
Recruiting
Not Applicable

Effectiveness of Stimulation on the Sciatic Nerve in ACLR

Anterior Cruciate Ligament Reconstruction Rehabilitation
Universidad de Murcia62 enrolled1 locationNCT07569796
Recruiting
Not Applicable

ACL Reconstruction Rehabilitation With Exercise and Psychological Support

Anterior Cruciate Ligament Reconstruction Rehabilitation
HealthPartners Institute60 enrolled1 locationNCT06991192
Recruiting

Do Patients With ACL Tears Demonstrate Weakness of the Soleus Muscle?

ACL InjuryACL TearACL - Anterior Cruciate Ligament Rupture
University of Liverpool55 enrolled1 locationNCT06235736
Recruiting
Not Applicable

Virtual Reality Mindfulness Meditation After ACL Reconstruction

Anterior cruciate ligament injury
University of North Carolina, Chapel Hill48 enrolled1 locationNCT05527171
Recruiting
Not Applicable

Steps Towards Osteoarthritis Prevention

Anterior Cruciate Ligament Injuries
University of Georgia56 enrolled1 locationNCT06193343
Recruiting
Not Applicable

Optimized Rehabilitation After Anterior Cruciate Ligament Before Returning to Sport

Anterior cruciate ligament ruptureLigament Knee Injury
Centre Hospitalier Universitaire de Saint Etienne432 enrolled8 locationsNCT05323474
Recruiting
Not Applicable

The Effect of Hyperbaric Oxygen Therapy for Acceleration Recovery After Anterior Cruciate Ligament Reconstruction(ACLR)

Anterior cruciate ligament reconstruction
Assaf-Harofeh Medical Center40 enrolled1 locationNCT06493851
Recruiting
Phase 1

Anterior Cruciate Ligament (ACL) Reconstruction With Autologous Fat Pad Derived Mesenchymal Stem Cells

Anterior cruciate ligament reconstruction
The Methodist Hospital Research Institute15 enrolled1 locationNCT06798623
Recruiting

Baseline ACL Injury Risk Screening and Normative Data

Musculoskeletal injuryAnterior Cruciate Ligament InjuriesACL Injury
Sanford Health5,000 enrolled1 locationNCT06635668