Anterior cruciate ligament Clinical Trials

124 recruitingLast updated: May 11, 2026

There are 124 actively recruiting anterior cruciate ligament clinical trials across 36 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1, Early Phase 1. Top locations include Chapel Hill, North Carolina, United States, Ankara, Turkey (Türkiye), Beijing, China. Updated daily from ClinicalTrials.gov.


Anterior cruciate ligament Trials at a Glance

124 actively recruiting trials for anterior cruciate ligament are listed on ClinicalTrialsFinder across 6 cities in 36 countries. The largest study group is Not Applicable with 77 trials, with the heaviest enrollment activity in Chapel Hill, Ankara, and Beijing. Lead sponsors running anterior cruciate ligament studies include Peking University Third Hospital, University of North Carolina, Chapel Hill, and Centre Hospitalier Universitaire de Saint Etienne.

Browse anterior cruciate ligament trials by phase

Treatments under study

About Anterior cruciate ligament Clinical Trials

Looking for clinical trials for Anterior cruciate ligament? There are currently 5 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Anterior cruciate ligament trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Anterior cruciate ligament clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 124 trials

Recruiting
Not Applicable

Prospective Evaluation of Silk Fibroin Incision Dressings in ACL Reconstruction

Anterior cruciate ligament reconstruction
NYU Langone Health100 enrolled1 locationNCT07217613
Recruiting
Not Applicable

Cross Bracing Protocol Versus Surgery for Acute Anterior Cruciate Ligament Rupture

Anterior cruciate ligament rupture
University of Melbourne180 enrolled1 locationNCT06956339
Recruiting
Not Applicable

Determining the Effects of Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After ACL Reconstruction

Anterior Cruciate Ligament Reconstruction RehabilitationQuadriceps Muscle Function
Arcadia University42 enrolled1 locationNCT07128602
Recruiting
Not Applicable

Effectiveness of Stimulation on the Sciatic Nerve in ACLR

Anterior Cruciate Ligament Reconstruction Rehabilitation
Universidad de Murcia62 enrolled1 locationNCT07569796
Recruiting
Not Applicable

Analysis Of Knee Joint Of Patients With Anterior Cruciate Ligament Injury Undergoing Physiotherapy After Two Different Surgical Techniques: A Randomized Clinical Trial.

Anterior Cruciate Ligament (ACL) TearAnterior Cruciate Ligament Reconstruction Rehabilitation
Universidade Estadual de Londrina20 enrolled3 locationsNCT06809920
Recruiting
Not Applicable

ACL Reconstruction Rehabilitation With Exercise and Psychological Support

Anterior Cruciate Ligament Reconstruction Rehabilitation
HealthPartners Institute60 enrolled1 locationNCT06991192
Recruiting

Do Patients With ACL Tears Demonstrate Weakness of the Soleus Muscle?

ACL InjuryACL TearACL - Anterior Cruciate Ligament Rupture
University of Liverpool55 enrolled1 locationNCT06235736
Recruiting
Not Applicable

Virtual Reality Mindfulness Meditation After ACL Reconstruction

Anterior cruciate ligament injury
University of North Carolina, Chapel Hill48 enrolled1 locationNCT05527171
Recruiting
Not Applicable

Steps Towards Osteoarthritis Prevention

Anterior Cruciate Ligament Injuries
University of Georgia56 enrolled1 locationNCT06193343
Recruiting
Not Applicable

Optimized Rehabilitation After Anterior Cruciate Ligament Before Returning to Sport

Anterior cruciate ligament ruptureLigament Knee Injury
Centre Hospitalier Universitaire de Saint Etienne432 enrolled8 locationsNCT05323474
Recruiting
Not Applicable

The Effect of Hyperbaric Oxygen Therapy for Acceleration Recovery After Anterior Cruciate Ligament Reconstruction(ACLR)

Anterior cruciate ligament reconstruction
Assaf-Harofeh Medical Center40 enrolled1 locationNCT06493851
Recruiting
Phase 1

Anterior Cruciate Ligament (ACL) Reconstruction With Autologous Fat Pad Derived Mesenchymal Stem Cells

Anterior cruciate ligament reconstruction
The Methodist Hospital Research Institute15 enrolled1 locationNCT06798623
Recruiting

Baseline ACL Injury Risk Screening and Normative Data

Musculoskeletal injuryAnterior Cruciate Ligament InjuriesACL Injury
Sanford Health5,000 enrolled1 locationNCT06635668
Recruiting
Not Applicable

Effects of Preoperative Rehabilitation on Tendon Healing, Bone Mineral Density, and Cartilage After ACLR and Patellar Dislocation

Anterior cruciate ligament rupture
Peking University Third Hospital60 enrolled1 locationNCT05924178
Recruiting

Effect of Graft Type on Knee Muscle Strength After ACL Reconstruction

Anterior Cruciate Ligament Reconstruction RehabilitationAnterior Cruciate Ligament (ACL) Reconstruction SurgeryStrength Outcomes
Hacettepe University80 enrolled1 locationNCT07523854
Recruiting
Not Applicable

Tourniquet vs. Dual-flow Arthroscopy Sheath in Anterior Cruciate Ligament (ACL) Reconstruction

Anterior cruciate ligament reconstruction
Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer128 enrolled2 locationsNCT06819696
Recruiting
Not Applicable

Effects of a Preoperative Cognitive-Behavioral Intervention on Kinesiophobia and Function in Anterior Cruciate Ligament Reconstruction

Anterior Cruciate Ligament (ACL) Tear
Peking University Third Hospital44 enrolled2 locationsNCT07423767
Recruiting

Clinical Outcomes of Arthroscopic Surgeries for Shoulder and Knee Sports Injuries

Anterior Cruciate Ligament InjuriesShoulder Dislocation or SubluxationPosterior Cruciate Ligament Tear+3 more
Second Affiliated Hospital, School of Medicine, Zhejiang University500 enrolled1 locationNCT07501013
Recruiting
Phase 4

Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction

Anterior cruciate ligament ruptureAnterior Cruciate Ligament InjuriesAnterior Cruciate Ligament tear
The Methodist Hospital Research Institute84 enrolled1 locationNCT06511232
Recruiting
Not Applicable

Bracing and Reconstruction of the Anterior Cruciate Ligament for Efficacy Trial

Anterior Cruciate Ligament Injuries
Wake Forest University Health Sciences96 enrolled1 locationNCT06942754