ACL Clinical Trials

101 recruitingLast updated: July 25, 2026

There are 101 actively recruiting acl clinical trials across 28 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1, Early Phase 1. Top locations include New York, New York, United States, Bologna, Bologna, Italy, Chicago, Illinois, United States. Updated daily from ClinicalTrials.gov.


ACL Trials at a Glance

101 actively recruiting trials for acl are listed on ClinicalTrialsFinder across 6 cities in 28 countries. The largest study group is Not Applicable with 46 trials, with the heaviest enrollment activity in New York, Bologna, and Chicago. Lead sponsors running acl studies include Stefano Zaffagnini, Tianjin Medical University Second Hospital, and GCS Ramsay Santé pour l'Enseignement et la Recherche.

Treatments under study

About ACL Clinical Trials

Looking for clinical trials for ACL? There are currently 10 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new ACL trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about ACL clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 101 trials

Recruiting
Not Applicable

Effects of Blood Flow Restriction Training and Instrument-Assisted Soft Tissue Mobilization for Pain, Strength, Range of Motion, and Kinesiophobia Among ACL Reconstruction Patients.

ACL reconstruction
Lahore University of Biological and Applied Sciences46 enrolled1 locationNCT07662850
Recruiting
Phase 1Phase 2

A Phase I/II Study of Intraperitoneal Paclitaxel in Patients With Metastatic Appendiceal Adenocarcinoma

Metastatic Appendiceal AdenocarcinomaIntraperitoneal Paclitaxel
M.D. Anderson Cancer Center39 enrolled1 locationNCT06207305
Recruiting
Not Applicable

Quadriceps Strengthening ACL Reconstruction

ACL Tear
Stanford University40 enrolled1 locationNCT07015541
Recruiting

ACL Reconstruction: Clinical Outcome

ACL Injury
Stefano Zaffagnini1,000 enrolled1 locationNCT03441659
Recruiting

Predicting Peripheral Neuropathy of Paclitaxel for Gastric Cancer

Gastric CancerChemotherapy Induced Peripheral NeuropathyPaclitaxel+1 more
City of Hope Medical Center150 enrolled1 locationNCT06490159
Recruiting

Long-term Clinical and Radiographic Results of Revision Anterior Cruciate Ligament Reconstruction Using a Single-bundle Technique and External Tenodesis With Achilles Tendon Allograft.

ACLLET
Stefano Zaffagnini59 enrolled1 locationNCT06868147
Recruiting

Intraoperative Energy Expenditure During ACL Reconstruction Surgery

ACL InjuryMeniscal injuries
ASL Lecce80 enrolled1 locationNCT07683247
Recruiting
Not Applicable

Impact of Bupivacaine Dilution With Dextrose or Saline on Infraclavicular Block Outcomes

Bupivacainepostoperative analgesiaInfraclavicular Brachial Plexus Block+2 more
Burçin Alaçam, MD90 enrolled1 locationNCT07386327
Recruiting
Not Applicable

Right Versus Left Distal Axillary Vein Cannulation

Venous CannulationInfraclavicular Vein Cannulation
Alexandria University80 enrolled1 locationNCT06761326
Recruiting
Phase 2

Tislelizumab Combined With Anlotinib and Nab-paclitaxel in III Resectable Non-small Cell Lung Cancer : A Prospective, Single-Arm, Phase II Study

NSCLCTislelizumabNab-paclitaxel+1 more
Qilu Hospital of Shandong University34 enrolled1 locationNCT07089199
Recruiting
Early Phase 1

MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)

Post-traumatic OsteoarthritisACL InjuryMeniscus Tear
Austin V Stone30 enrolled1 locationNCT04572256
Recruiting

Augmented Reality in Surgery

Anterior Cruciate Ligament (ACL) Tear
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio100 enrolled1 locationNCT07636278
Recruiting
Not Applicable

The Pediatric ALL Evaluation and Trial

ACL InjuryACL Tear
Ann & Robert H Lurie Children's Hospital of Chicago240 enrolled1 locationNCT04825587
Recruiting
Not Applicable

The Effect of Pre-Operative Cryoneurolysis on Post-Operative Narcotic Consumption in Patients Undergoing Autograft ACL Reconstruction

ACL Repair
Virtua Health, Inc.20 enrolled2 locationsNCT06603051
Recruiting

Reducing Disparities in Knee Arthroscopy for Adolescents

AdolescentACL InjuryMeniscus Tear+2 more
Ann & Robert H Lurie Children's Hospital of Chicago80 enrolled1 locationNCT07580625
Recruiting
Not Applicable

Analysis Of Knee Joint Of Patients With Anterior Cruciate Ligament Injury Undergoing Physiotherapy After Two Different Surgical Techniques: A Randomized Clinical Trial.

Anterior Cruciate Ligament (ACL) TearAnterior Cruciate Ligament Reconstruction Rehabilitation
Universidade Estadual de Londrina20 enrolled3 locationsNCT06809920
Recruiting

Do Patients With ACL Tears Demonstrate Weakness of the Soleus Muscle?

ACL InjuryACL TearACL - Anterior Cruciate Ligament Rupture
University of Liverpool55 enrolled1 locationNCT06235736
Recruiting

Clinical and Biomechanical Outcomes of Anterior Cruciate Ligament (ACL) Reconstruction Associated With Lateral Extra-articular Tenodesis (LET)

ACL reconstructionACL InjuriesTenodesis
Stefano Zaffagnini51 enrolled1 locationNCT07049484
Recruiting

Baseline ACL Injury Risk Screening and Normative Data

Musculoskeletal injuryAnterior Cruciate Ligament InjuriesACL Injury
Sanford Health5,000 enrolled1 locationNCT06635668
Recruiting
Not Applicable

The Effect of Cold Salt Water Foot Bath on the Development Of Chemotherapy-Induced Peripheral Neuropathy

Breast Cancer PatientsChemotherapy-induced Peripheral Neuropathy (CIPN)Paclitaxel-induced Peripheral Neuropathy
Tuba Eryiğit30 enrolled1 locationNCT06964802