ACL Clinical Trials

9 recruiting

Frequently Asked Questions

Common questions about ACL clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 68 trials

Recruiting
Not Applicable

Preoperative Rehabilitation for Patient With an ACL Injury

Anterior Cruciate Ligament (ACL)
Nantes University Hospital84 enrolled1 locationNCT07411625
Recruiting

Assessment of Changes in Bone Mineral Metabolism After Liver Transplantation by Bone Mineral Densitometry

Chronic Liver Disease and ACLF
Institute of Liver and Biliary Sciences, India100 enrolled1 locationNCT07480057
Recruiting
Not Applicable

Impact of Bupivacaine Dilution With Dextrose or Saline on Infraclavicular Block Outcomes

BupivacaineInfraclavicular Brachial Plexus BlockDextrose+1 more
Burçin Alaçam, MD90 enrolled1 locationNCT07386327
Recruiting
Not Applicable

Comparison of Standard ACL Reconstruction Versus TARS-Augmented Reconstruction

Anterior Cruciate Ligament (ACL)
Samsun University80 enrolled1 locationNCT07418476
Recruiting
Not Applicable

Study of Functional Magnetic Resonance Signal Variations in Patients Undergoing Anterior Cruciate Ligament Reconstruction With the Application of a Dedicated Neuromotor Training

Rehabilitation ExerciseACL InjuryfMRI+1 more
Stefano Zaffagnini12 enrolled1 locationNCT07097077
Recruiting

Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry

Musculoskeletal DiseasesOsteoarthritisJoint Diseases+3 more
Xiaojuan Li88 enrolled1 locationNCT04536103
Recruiting

Do Patients With ACL Tears Demonstrate Weakness of the Soleus Muscle?

ACL Tear
University of Liverpool55 enrolled1 locationNCT06235736
Recruiting
Not Applicable

KRONOS Versus Breg T-Scope Post-operative Knee Braces Following Anterior Cruciate Ligament (ACL) Reconstruction

Anterior Cruciate Ligament (ACL) Reconstruction Surgery
Rush University Medical Center40 enrolled1 locationNCT07090616
Recruiting
Not Applicable

Michigan Split-belt Treadmill Training Program to Improve Acute Knee Biomechanics After ACL Reconstruction

ACL InjuryACL
University of Michigan30 enrolled1 locationNCT06529679
Recruiting

Baseline ACL Injury Risk Screening and Normative Data

Anterior Cruciate Ligament InjuriesACL Injury
Sanford Health5,000 enrolled1 locationNCT06635668
Recruiting

ACL Reconstruction: Clinical Outcome

ACL Injury
Stefano Zaffagnini1,000 enrolled1 locationNCT03441659
Recruiting
Phase 1Phase 2

A Phase I/II Study of Intraperitoneal Paclitaxel in Patients With Metastatic Appendiceal Adenocarcinoma

Metastatic Appendiceal AdenocarcinomaIntraperitoneal Paclitaxel
M.D. Anderson Cancer Center39 enrolled1 locationNCT06207305
Recruiting
Not Applicable

Quadriceps Strengthening ACL Reconstruction

ACL Tear
Stanford University40 enrolled1 locationNCT07015541
Recruiting
Not Applicable

VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR)

Opioid UsePain, PostoperativeCryotherapy Effect+2 more
Columbia University130 enrolled1 locationNCT06456268
Recruiting
Not Applicable

Muscle O2 Saturation and Hemoglobin Levels During Rehabilitation From Arthroscopic Surgery

ACL InjuryHip Injuries
University Hospitals Cleveland Medical Center226 enrolled2 locationsNCT05488054
Recruiting
Not Applicable

Augmentation of Partial Anterior Cruciate Ligament Tear: Early Results

ACL InjuryACL Augmentation
Assiut University30 enrolled1 locationNCT05391672
Recruiting
Not Applicable

Clinical-randomized Trial of the Effect of Rehabilitation Therapy Using Strength and Blood Flow Restriction Training on Muscular Fitness and Regeneration After Anterior Cruciate Ligament Reconstruction

ACL - Anterior Cruciate Ligament Rupture
University Hospital, Bonn30 enrolled1 locationNCT07043569
Recruiting
Not Applicable

Treatment of Post Traumatic Knee Osteoarthritis With Extracorporeal Shockwave Therapy

ACL InjuriesKnee OsteoarthristisPost-Traumatic
Spaulding Rehabilitation Hospital70 enrolled1 locationNCT06686680
Recruiting

BioBrace® Augmentation in Anterior Cruciate Ligament Reconstruction Procedures

ACL Tears
CONMED Corporation500 enrolled1 locationNCT06948591
Recruiting
Phase 4

Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction

Anterior Cruciate Ligament InjuriesACL InjuryPost-Traumatic Osteoarthritis of Knee+1 more
Hospital for Special Surgery, New York40 enrolled2 locationsNCT06311513