ACL Clinical Trials

95 recruitingLast updated: May 13, 2026

There are 95 actively recruiting acl clinical trials across 28 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1, Early Phase 1. Top locations include New York, New York, United States, Tianjin, Outside U.S., China, Cleveland, Ohio, United States. Updated daily from ClinicalTrials.gov.


ACL Trials at a Glance

95 actively recruiting trials for acl are listed on ClinicalTrialsFinder across 6 cities in 28 countries. The largest study group is Not Applicable with 44 trials, with the heaviest enrollment activity in New York, Tianjin, and Cleveland. Lead sponsors running acl studies include Stefano Zaffagnini, Tianjin Medical University Second Hospital, and Hebei Medical University Fourth Hospital.

Treatments under study

About ACL Clinical Trials

Looking for clinical trials for ACL? There are currently 10 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new ACL trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about ACL clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 95 trials

Recruiting
Not Applicable

Analysis Of Knee Joint Of Patients With Anterior Cruciate Ligament Injury Undergoing Physiotherapy After Two Different Surgical Techniques: A Randomized Clinical Trial.

Anterior Cruciate Ligament (ACL) TearAnterior Cruciate Ligament Reconstruction Rehabilitation
Universidade Estadual de Londrina20 enrolled3 locationsNCT06809920
Recruiting

Do Patients With ACL Tears Demonstrate Weakness of the Soleus Muscle?

ACL InjuryACL TearACL - Anterior Cruciate Ligament Rupture
University of Liverpool55 enrolled1 locationNCT06235736
Recruiting

Clinical and Biomechanical Outcomes of Anterior Cruciate Ligament (ACL) Reconstruction Associated With Lateral Extra-articular Tenodesis (LET)

ACL reconstructionACL InjuriesTenodesis
Stefano Zaffagnini51 enrolled1 locationNCT07049484
Recruiting
Not Applicable

Quadriceps Strengthening ACL Reconstruction

ACL Tear
Stanford University40 enrolled1 locationNCT07015541
Recruiting

Baseline ACL Injury Risk Screening and Normative Data

Musculoskeletal injuryAnterior Cruciate Ligament InjuriesACL Injury
Sanford Health5,000 enrolled1 locationNCT06635668
Recruiting

BioBrace® Augmentation in Anterior Cruciate Ligament Reconstruction Procedures

ACL Tears
CONMED Corporation500 enrolled1 locationNCT06948591
Recruiting
Not Applicable

The Effect of Cold Salt Water Foot Bath on the Development Of Chemotherapy-Induced Peripheral Neuropathy

Breast Cancer PatientsChemotherapy-induced Peripheral Neuropathy (CIPN)Paclitaxel-induced Peripheral Neuropathy
Tuba Eryiğit30 enrolled1 locationNCT06964802
Recruiting

Effect of Graft Type on Knee Muscle Strength After ACL Reconstruction

Anterior Cruciate Ligament Reconstruction RehabilitationAnterior Cruciate Ligament (ACL) Reconstruction SurgeryStrength Outcomes
Hacettepe University80 enrolled1 locationNCT07523854
Recruiting
Not Applicable

Effects of a Preoperative Cognitive-Behavioral Intervention on Kinesiophobia and Function in Anterior Cruciate Ligament Reconstruction

Anterior Cruciate Ligament (ACL) Tear
Peking University Third Hospital44 enrolled2 locationsNCT07423767
Recruiting
Not Applicable

Preoperative Rehabilitation for Patient With an ACL Injury

Anterior Cruciate Ligament (ACL)
Nantes University Hospital84 enrolled1 locationNCT07411625
Recruiting

Assessment of Changes in Bone Mineral Metabolism After Liver Transplantation by Bone Mineral Densitometry

Chronic Liver Disease and ACLF
Institute of Liver and Biliary Sciences, India100 enrolled1 locationNCT07480057
Recruiting
Not Applicable

Comparison of Bone-patellar Tendon-bone and Patellar Tendon-bone Grafts in ACL Reconstruction

Anterior cruciate ligament injuryAnterior cruciate ligament (ACL) reconstruction
Universidad de Granada110 enrolled1 locationNCT07475351
Recruiting
Phase 2

Comparison of Functional Outcomes Following Arthroscopic ACL Reconstruction With Peroneus Longus Autograft With and Without Intra-articular Platelet-Rich Plasma Injection.

ACL reconstructionPRPIntraarticular Injection
Lahore General Hospital60 enrolled1 locationNCT07470359
Recruiting
Not Applicable

Impact of Bupivacaine Dilution With Dextrose or Saline on Infraclavicular Block Outcomes

Bupivacainepostoperative analgesiaInfraclavicular Brachial Plexus Block+2 more
Burçin Alaçam, MD90 enrolled1 locationNCT07386327
Recruiting
Not Applicable

Effect of Internal Brace on Outcomes Following ACL Reconstruction With BTB Autograft

ACL reconstruction
NYU Langone Health90 enrolled1 locationNCT06542705
Recruiting
Not Applicable

Comparison of Standard ACL Reconstruction Versus TARS-Augmented Reconstruction

Anterior Cruciate Ligament (ACL)
Samsun University80 enrolled1 locationNCT07418476
Recruiting
Not Applicable

Personalized Digital Training Intervention to Reduce Inflammation by Correcting Pathological Movement Patterns in Pre-stage Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction

ACL reconstructionOsteoarthritis(OA) of the knee
Charite University, Berlin, Germany60 enrolled2 locationsNCT06596824
Recruiting
Not Applicable

Study of Functional Magnetic Resonance Signal Variations in Patients Undergoing Anterior Cruciate Ligament Reconstruction With the Application of a Dedicated Neuromotor Training

Rehabilitation ExerciseACL InjuryfMRI+1 more
Stefano Zaffagnini12 enrolled1 locationNCT07097077
Recruiting

Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry

Musculoskeletal DiseasesOsteoarthritisJoint Diseases+3 more
Xiaojuan Li88 enrolled1 locationNCT04536103
Recruiting
Phase 2

Subdermal Implant-bioabsorbable Oxandrolone Pellet For Rehabilitation Following Anterior Cruciate Ligament (ACL) Surgical Reconstruction

Anterior cruciate ligament (ACL) reconstruction
Science Valley Research Institute96 enrolled6 locationsNCT06974526