Aortic Valve Insufficiency Clinical Trials

10 recruitingLast updated: May 21, 2026

There are 10 actively recruiting aortic valve insufficiency clinical trials across 13 countries. Studies span Not Applicable. Top locations include Houston, Texas, United States, Plano, Texas, United States, Atlanta, Georgia, United States. Updated daily from ClinicalTrials.gov.


Aortic Valve Insufficiency Trials at a Glance

10 actively recruiting trials for aortic valve insufficiency are listed on ClinicalTrialsFinder across 6 cities in 13 countries. The largest study group is Not Applicable with 5 trials, with the heaviest enrollment activity in Houston, Plano, and Atlanta. Lead sponsors running aortic valve insufficiency studies include JenaValve Technology, Inc., Duk-Woo Park, MD, and Closed Joint-Stock Company NeoCor.

Browse aortic valve insufficiency trials by phase

About Aortic Valve Insufficiency Clinical Trials

Looking for clinical trials for Aortic Valve Insufficiency? There are currently 9 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Aortic Valve Insufficiency trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Aortic Valve Insufficiency clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 110 of 10 trials

Recruiting
Not Applicable

Von Willebrand Factor Point-of-care Testing to Improve Minimally Invasive TAVI Outcomes

Aortic Valve StenosisAortic Valve Insufficiency
University Hospital, Lille944 enrolled9 locationsNCT03728049
Recruiting
Not Applicable

ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™

Aortic Valve InsufficiencyAortic Insufficiencyaortic regurgitation
JenaValve Technology, Inc.1,016 enrolled24 locationsNCT06608823
Recruiting
Not Applicable

The JenaValve ALIGN-AR LVAD Registry

Aortic Valve DiseaseLeft Ventricular DysfunctionAortic Valve Insufficiency+2 more
JenaValve Technology, Inc.50 enrolled15 locationsNCT06594705
Recruiting
Not Applicable

ART Trial: Transcatheter J-VALVE Versus Surgery for Aortic Regurgitation Therapy

Aortic Valve InsufficiencyAortic Insufficiencyaortic regurgitation
Second Affiliated Hospital, School of Medicine, Zhejiang University1,250 enrolled12 locationsNCT07453407
Recruiting

Transpacific TAVR Registry

Heart Valve DiseasesAortic Valve Insufficiency
Duk-Woo Park, MD10,000 enrolled7 locationsNCT03826264
Recruiting
Not Applicable

ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves

Aortic Valve StenosisAortic Valve Insufficiency
Edwards Lifesciences200 enrolled35 locationsNCT05172973
Recruiting

Study on Efficacy, Safety and Durability of the UniLine Prosthesis in the Treatment of Aortic and Mitral Valve Disease

Diseases of Mitral and Aortic ValvesRheumatic Disorders of Mitral and Aortic ValvesOther Congenital Malformations of Aortic and Mitral Valves+2 more
Closed Joint-Stock Company NeoCor2,000 enrolled1 locationNCT05895487
Recruiting

Avalus European Registry - an Observational Study to Evaluate Safety and Efficacy in a Real World Population

Aortic Valve StenosisAortic Valve Insufficiency
Universitaire Ziekenhuizen KU Leuven1,000 enrolled19 locationsNCT05572710
Recruiting

European Association of Cardiovascular Imaging Multiple and Mixed Valvular Disease Study

Aortic Valve DiseaseHeart Valve DiseasesTricuspid Valve Insufficiency+11 more
Assistance Publique - Hôpitaux de Paris1,500 enrolled1 locationNCT06235385
Recruiting

Results of the Aortic Valve Reconstruction in Children

Aortic Valve Insufficiency
National Medical Research Center for Children's Health, Russian Federation40 enrolled1 locationNCT04162444