Orthostatic Hypotension Clinical Trials

17 recruiting

Orthostatic Hypotension Trials at a Glance

25 actively recruiting trials for orthostatic hypotension are listed on ClinicalTrialsFinder across 6 cities in 12 countries. The largest study group is Not Applicable with 14 trials, with the heaviest enrollment activity in Nashville, West Orange, and Rochester. Lead sponsors running orthostatic hypotension studies include Vanderbilt University Medical Center, Kessler Foundation, and University of Calgary.

Browse orthostatic hypotension trials by phase

Treatments under study

About Orthostatic Hypotension Clinical Trials

Looking for clinical trials for Orthostatic Hypotension? There are currently 17 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Orthostatic Hypotension trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Orthostatic Hypotension clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 25 trials

Recruiting
Not Applicable

Deciphering Preserved Autonomic Function After Spinal Cord Injury

Spinal Cord InjuriesOrthostatic HypotensionAutonomic Dysreflexia+1 more
Mayo Clinic69 enrolled1 locationNCT04493372
Recruiting
Not Applicable

The Effect of Water Carbonation on Orthostatic Tolerance

Orthostatic HypotensionSyncopeVasovagal Syncope
Simon Fraser University25 enrolled1 locationNCT05621460
Recruiting
Not Applicable

Blood Pressure Effects on Cognition and Brain Blood Flow in PD

DysautonomiaParkinson DiseaseOrthostatic Hypotension
University of California, San Diego60 enrolled1 locationNCT05400174
Recruiting
Not Applicable

CPAP for the Treatment of Supine Hypertension

Multiple System AtrophyParkinson DiseaseAutonomic Failure+3 more
Vanderbilt University Medical Center59 enrolled1 locationNCT05489575
Recruiting

Autonomic Regulation of Blood Pressure and Heart Rate During Orthostasis and Exercise in Healthy and Hypertensive Individuals

Autonomic DysfunctionHypertensionOrthostatic Hypotension
University Medical Centre Ljubljana120 enrolled1 locationNCT07482462
Recruiting
Phase 2

A Study in Subjects With Neurogenic Orthostatic Hypotension

Neurogenic Orthostatic Hypotension
CuraSen Therapeutics, Inc.12 enrolled4 locationsNCT07089043
Recruiting
Phase 1Phase 2

Feasibility Study Assessing the Effect of Carbidopa/Levodopa Ratio on Orthostatic Hypotension in Multiple System Atrophy - Parkinsonian Type and Parkinson Disease.

Parkinson DiseaseOrthostatic Hypotension, DysautonomicMulti-system Atrophy - Parkinsonian Type
Julien Bally36 enrolled2 locationsNCT06831500
Recruiting
Phase 1

Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure

Multiple System AtrophyAutonomic FailurePure Autonomic Failure+1 more
Vanderbilt University Medical Center29 enrolled1 locationNCT02429557
Recruiting
Early Phase 1

Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients

Multiple System AtrophyParkinson DiseaseAutonomic Failure+2 more
Vanderbilt University Medical Center31 enrolled1 locationNCT04620382
Recruiting
Not Applicable

Epidural Electrical Stimulation to Support Hemodynamic Management in Individuals With Parkinson's Disease

Parkinson's DiseaseHypotension SymptomaticOrthostatic Hypotension, Dysautonomic+2 more
Ecole Polytechnique Fédérale de Lausanne5 enrolled1 locationNCT06920134
Recruiting
Phase 1Phase 2

Automated Abdominal Binder for Orthostatic Hypotension

Multiple System AtrophyAutonomic FailurePure Autonomic Failure+1 more
Vanderbilt University Medical Center31 enrolled1 locationNCT03482297
Recruiting
Phase 1

Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure

Multiple System AtrophyParkinson DiseaseAutonomic Failure+2 more
Vanderbilt University Medical Center34 enrolled1 locationNCT02897063
Recruiting
Not Applicable

The STAND-UP Study

Orthostatic Hypotension, Dysautonomic
St. Francis Hospital, New York100 enrolled1 locationNCT07195903
Recruiting
Not Applicable

Evaluation of the Contribution of Lower Limb and/or Abdominal Compression on Orthostatic Hypotension

Orthostatic Hypotension
Gérond'if44 enrolled2 locationsNCT06694688
Recruiting
Not Applicable

The Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI)

Cardiovascular DiseasesCentral Nervous System DiseasesBlood Pressure+6 more
Kessler Foundation5 enrolled1 locationNCT05725499
Recruiting
Not Applicable

Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)

Cardiovascular DiseasesCentral Nervous System DiseasesBlood Pressure+7 more
Kessler Foundation12 enrolled1 locationNCT05731986
Recruiting
Not Applicable

Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury

Spinal Cord Injuries (SCI)Orthostatic Hypotension, DysautonomicCardiovascular+1 more
Kessler Foundation5 enrolled1 locationNCT06841198
Recruiting

Natural History Study of Synucleinopathies

Multiple System AtrophyParkinson DiseaseDementia With Lewy Bodies+5 more
NYU Langone Health800 enrolled8 locationsNCT01799915
Recruiting

The Value of Near-infrared Spectroscopy and Blood Pressure Measurements in Estimating Future Fall Risk in Older Adults

Older Adults (65 Years and Older)Orthostatic HypotensionFalls
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)141 enrolled1 locationNCT06714565
Recruiting
Not Applicable

Hypercapnia in Orthostatic Hypotension

Orthostatic HypotensionNeurogenic Orthostatic Hypotension
University of Calgary80 enrolled1 locationNCT05295810