Phase 2 Brain Tumor Clinical Trials
23 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 23 trials
Recruiting
Phase 1Phase 2
A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations
CancerBrain Tumor
National Cancer Institute (NCI)96 enrolled1 locationNCT05588141
Recruiting
Phase 2
A Study Comparing GLIADEL to Stereotactic Radiosurgery in Metastatic Brain Disease
Brain Tumor - Metastatic
University of Nebraska100 enrolled2 locationsNCT04222062
Recruiting
Phase 2
Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
Metastatic Brain TumorGlioblastomaGlioblastoma Multiforme+7 more
Nationwide Children's Hospital120 enrolled21 locationsNCT05843253
Recruiting
Phase 2
Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA
Brain TumorBrain CancerGlioblastoma+6 more
Northwell Health37 enrolled1 locationNCT02800486
Recruiting
Phase 1Phase 2
Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas
OsteosarcomaEwing SarcomaNeuroblastoma+4 more
Milton S. Hershey Medical Center289 enrolled10 locationsNCT06465199
Recruiting
Phase 1Phase 2
Safety and Efficacy of Bevacizumab in Combination With NaviFUS System for the Treatment of Recurrent Glioblastoma Multiforme (rGBM)
NeoplasmsBrain TumorGlioblastoma+3 more
NaviFUS Corporation10 enrolled1 locationNCT06329570
Recruiting
Phase 2
Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction
Brain Metastases, AdultBrain Tumor - MetastaticBrain Metastases From Non-small Cell Lung Cancer (NSCLC)+1 more
Ayal A. Aizer, MD60 enrolled1 locationNCT07132190
Recruiting
Phase 1Phase 2
Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures
Brain Tumor
Stanford University12 enrolled1 locationNCT04085887
Recruiting
Phase 2
ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids
Brain TumorGlioblastomaBrain Tumor, Recurrent+1 more
University of Birmingham120 enrolled22 locationsNCT05629702
Recruiting
Phase 1Phase 2
Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer
Refractory CancerRecurrent CancerChildhood Cancer+2 more
Australian & New Zealand Children's Haematology/Oncology Group90 enrolled14 locationsNCT06208657
Recruiting
Phase 1Phase 2
Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age
Glioblastoma MultiformeOligodendrogliomaDiffuse Intrinsic Pontine Glioma+5 more
University of Miami20 enrolled1 locationNCT05956821
Recruiting
Phase 1Phase 2
A Study of the Boron Neutron Capture Therapy (BNCT) Using B10 L-BPA in Malignant Brain Tumors
Malignant Brain Tumors
China Medical University Hospital10 enrolled2 locationsNCT07003139
Recruiting
Phase 1Phase 2
Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG)
Brain Tumor
InSightec10 enrolled3 locationsNCT05630209
Recruiting
Phase 2
A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 Gliomas
Brain TumorGlioblastoma
Case Comprehensive Cancer Center48 enrolled1 locationNCT07003542
Recruiting
Phase 2
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
Pancreatic CancerGastric CancerLung Cancer+15 more
Apollomics Inc.497 enrolled35 locationsNCT03175224
Recruiting
Phase 1Phase 2
Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG
Brain Tumor
InSightec10 enrolled1 locationNCT05615623
Recruiting
Phase 1Phase 2
Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM
CancerBrain TumorBrain Cancer+6 more
Northwell Health67 enrolled1 locationNCT03213002
Recruiting
Phase 1Phase 2
Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma
Brain TumorBrain CancerGlioblastoma+4 more
Northwell Health33 enrolled1 locationNCT02861898
Recruiting
Phase 2
Study of Olutasidenib and Temozolomide in HGG
Metastatic Brain TumorIDH1 MutationAstrocytoma, Grade IV+16 more
Rigel Pharmaceuticals60 enrolled18 locationsNCT06161974
Recruiting
Phase 1Phase 2
TIL Therapy Combined With Pembrolizumab for Advanced Brain Cancer Including Gliomas and Meningiomas
Brain MetastasesBrain TumorBrain Cancer+4 more
Essen Biotech85 enrolled1 locationNCT06640582