Early Phase 1 Cancer Clinical Trials
146 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 146 trials
Recruiting
Early Phase 1
Effects of a Probiotic Intervention on the Gut and Vaginal Microbiome in Patients With Advanced or Recurrent Ovarian Cancer Undergoing Treatment With Platinum Chemotherapy
Recurrent Ovarian CarcinomaStage III Ovarian Cancer AJCC v8Stage IV Ovarian Cancer AJCC v8+2 more
Ohio State University Comprehensive Cancer Center161 enrolled1 locationNCT07144826
Recruiting
Early Phase 1
Lidocaine Infusion in Pancreatic Cancer
Pancreatic Cancer
University of Illinois at Chicago46 enrolled1 locationNCT04048278
Recruiting
Early Phase 1
A Study of Dose Escalation of ES502 in Patients With Advanced Pancreatic Cancer
Pancreatic Cancer
Ruijin Hospital24 enrolled1 locationNCT07649928
Recruiting
Early Phase 1
First-in-human Diagnostic Imaging Profile of the Theranostic Pair [68Ga]Ga-DOTA-STR-17126 and Low Dose [177Lu] Lu-DOTA-STR-17126 in Patients With Advanced or Metastatic Cancer
Metastatic Breast CancerCancerMetastatic Prostate Cancer+5 more
Integrated Haematology and Oncology Network20 enrolled1 locationNCT07608848
Recruiting
Early Phase 1
Immunological Effects of Vitamin D Replacement Among Black/African American Prostate Cancer Patients
Metastatic Prostate CarcinomaStage IV Prostate Cancer AJCC v8Localized Prostate Carcinoma+1 more
Mayo Clinic220 enrolled2 locationsNCT05045066
Recruiting
Early Phase 1
A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant Recipients
Skin CancerCutaneous Squamous Cell Carcinoma (CSCC)Actinic Keratosis (AK)+1 more
Marissa Lobl20 enrolled2 locationsNCT07286318
Recruiting
Early Phase 1
Pragmatic Trial of Metformin for Glucose Intolerance or Increased BMI in Prostate Cancer Patients
Prostate Cancer
University of Colorado, Denver100 enrolled4 locationsNCT05515978
Recruiting
Early Phase 1
Monitoring Breast Cancer Immunotherapy Treatment With Advanced Positron Emission Tomography Magnetic Resonance Imaging (PET/MRI)
Triple-Negative Breast Cancer
University of Alabama at Birmingham20 enrolled1 locationNCT04861077
Recruiting
Early Phase 1
Prospective Screening for Pancreatic Ductal Adenocarcinoma in High-Risk Individuals
Pancreatic CancerPancreatic Ductal AdenocarcinomaPDAC+2 more
Dana-Farber Cancer Institute5,000 enrolled2 locationsNCT06122896
Recruiting
Early Phase 1
CDH17 CAR-T Therapy in Advanced Malignant Solid Tumors
Biliary Tract CancerColorectal CarcinomaGastric Cancer, Metastatic+2 more
Zhejiang University36 enrolled1 locationNCT06937567
Recruiting
Early Phase 1
Active Surveillance and Chemotherapy Before Surgery in Treating Participants With Stage II-III Rectal Cancer
Rectal AdenocarcinomaStage II Rectal Cancer AJCC v8Stage III Rectal Cancer AJCC v8+6 more
M.D. Anderson Cancer Center120 enrolled1 locationNCT03594630
Recruiting
Early Phase 1
Preliminary Trial of SNA014 for Pancreatic Cancer
Pancreatic Cancer
SmartNuclide Biopharma12 enrolled1 locationNCT07597772
Recruiting
Early Phase 1
A Phase I Study on Evaluating the Safety, Tolerability, Pharmacokinetic Characteristics and Preliminary Efficacy of SXRN Plasmid DNA Technique in Patients With Advanced Solid Tumors
Advanced CancerCachexia
Jiangsu Nutai Biologics Co., Ltd28 enrolled1 locationNCT06736275
Recruiting
Early Phase 1
Botensilimab, Balstilimab, and SBRT in Colorectal Cancer
Non-MSI-H or pMMR Colorectal Cancer With Liver Metastasis
Massachusetts General Hospital15 enrolled1 locationNCT07128355
Recruiting
Early Phase 1
A IIT Study of 177Lu-DOTA-SNA040
Advanced Solid Tumors (Such as Gastric Cancer)Advanced Solid Tumors (Such as Adenocarcinoma at the Gastroesophageal Junction)Advanced Solid Tumors (Such as Pancreatic Cancer)+1 more
SmartNuclide Biopharma12 enrolled1 locationNCT07595237
Recruiting
Early Phase 1
Vitamin D in Patients With Stage I-III Colon Cancer or Resectable Colon Cancer Liver Metastases
Stage, Colon CancerStage I-III Colon CancerStage IV Colon Cancer With Resectable Liver Metastases
Dana-Farber Cancer Institute80 enrolled1 locationNCT02172651
Recruiting
Early Phase 1
Neoadjuvant Dupilumab, Pembrolizumab, Paclitaxel, and Carboplatin in Locally Advanced Triple Negative Breast Cancer
TNBC - Triple-Negative Breast CancerLocally Advanced Triple Negative Breast Cancer
Rima Patel15 enrolled1 locationNCT06637306
Recruiting
Early Phase 1
Clinical Application of CAIX-Targeted PET Imaging in Tumors
Kidney Cancers
Peking University Cancer Hospital & Institute3 enrolled1 locationNCT07590310
Recruiting
Early Phase 1
Efficacy and Safety of Neoadjuvant Cadonilimab Plus High-Dose Recombinant Human Interferon α1b in Stage III/IV Melanoma.
Melanoma (Skin Cancer)
Xijing Hospital10 enrolled1 locationNCT07586904
Recruiting
Early Phase 1
Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG)
Brain CancerGliomaHigh Grade Glioma+4 more
Eben Rosenthal38 enrolled1 locationNCT07210632