Chronic fatigue Clinical Trials

26 recruitingLast updated: May 13, 2026

There are 26 actively recruiting chronic fatigue clinical trials across 9 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3. Top locations include New York, New York, United States, Warsaw, Masovian Voivodeship, Poland, Bethesda, Maryland, United States. Updated daily from ClinicalTrials.gov.


Chronic fatigue Trials at a Glance

26 actively recruiting trials for chronic fatigue are listed on ClinicalTrialsFinder across 6 cities in 9 countries. The largest study group is Not Applicable with 8 trials, with the heaviest enrollment activity in New York, Warsaw, and Bethesda. Lead sponsors running chronic fatigue studies include Deakin University, Icahn School of Medicine at Mount Sinai, and National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland.

Browse chronic fatigue trials by phase

Treatments under study

About Chronic fatigue Clinical Trials

Looking for clinical trials for Chronic fatigue? There are currently 3 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Chronic fatigue trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Chronic fatigue clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 26 trials

Recruiting
Not Applicable

RCT of Mind-body in Long COVID and Myalgic Encephalomyelitis

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
University of Alberta200 enrolled3 locationsNCT06933173
Recruiting
Not Applicable

Transcutaneous Vagus Nerve Stimulation as a Complementary Therapy to Exercise in Chronic Fatigue

Chronic Fatigue Syndrome
Centre Hospitalier Universitaire de Saint Etienne60 enrolled1 locationNCT06170645
Recruiting

Patient-Centered Assessment of Symptoms and Outcomes

Myalgic Encephalomyelitis/Chronic Fatigue SyndromeCancerFatigue+5 more
National Center for Complementary and Integrative Health (NCCIH)692 enrolled1 locationNCT03952624
Recruiting

Observational Study on Immunoadsorption (IA) in Patients With Autoantibody-Positive Post-Infectious ME/CFS

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)ME/CFS Following COVID-19
Charite University, Berlin, Germany50 enrolled1 locationNCT07529197
Recruiting
Phase 1Phase 2

Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Myalgic EncephalomyelitisChronic Fatigue SyndromePost-treatment Lyme Disease Syndrome+1 more
Icahn School of Medicine at Mount Sinai120 enrolled1 locationNCT06511050
Recruiting

Chronic Infections and Inflammation in ME/CFS: An Observational Study

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
University of California, San Francisco200 enrolled1 locationNCT07227441
Recruiting
Phase 2

Assessment of N-Acetylcysteine as Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Myalgic EncephalomyelitisChronic Fatigue Syndrome
Weill Medical College of Cornell University95 enrolled1 locationNCT04542161
Recruiting
Not Applicable

Effect of Physical Exercise and Neuromodulation on Pain, Sleep and Fatigue in Patients With Fibromyalgia

FibromyalgiaChronic Fatigue Syndrome (CFS)
National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland75 enrolled1 locationNCT07242573
Recruiting
Phase 1

Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.

Chronic Fatigue SyndromeHealthyMultiple Sclerosis+1 more
University of Alabama at Birmingham120 enrolled1 locationNCT03759522
Recruiting
Not Applicable

A 3-day Course for CFS/ME

Myalgic EncephalomyelitisChronic Fatigue Syndrome
Norwegian University of Science and Technology100 enrolled1 locationNCT05236465
Recruiting
Phase 2

Ca-Mg Butyrate in GWI

Chronic fatigueNeurocognitive DysfunctionGulf War Illness
VA Office of Research and Development120 enrolled3 locationsNCT05367245
Recruiting
Not Applicable

tVNS in Long COVID-19

Chronic Fatigue SyndromeLong COVID
Icahn School of Medicine at Mount Sinai50 enrolled1 locationNCT06585254
Recruiting
Not Applicable

Internet-based Treatment for Patients Suffering From Severe Functional Somatic Disorders

Chronic Fatigue SyndromeFibromyalgiaIrritable Bowel Syndrome+3 more
University of Aarhus166 enrolled1 locationNCT05525598
Recruiting
Not Applicable

Hydrogen Water Intervention With Heart Rate Variability as an Outcome Biomarker in ME/CFS

Chronic Fatigue Syndrome
Stony Brook University50 enrolled1 locationNCT07009691
Recruiting
Not Applicable

The Long COVID-19 Wearable Device Study

Postural Orthostatic tachycardia SyndromeMyalgic EncephalomyelitisChronic Fatigue Syndrome+3 more
Scripps Translational Science Institute100,500 enrolled1 locationNCT05741112
Recruiting
Phase 2

Study of the Efficacy and Safety for Rituximab in Myalgia Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Myalgia Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
National Center of Neurology and Psychiatry, Japan30 enrolled1 locationNCT06952413
Recruiting
Phase 2Phase 3

TRI-ME: Trimetazidine to treat Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A double-blind, randomised, placebo-controlled efficacy trial

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Deakin University126 enrolled1 locationACTRN12625000095460
Recruiting

FUNCAP-27 (Functional Capacity), A Repeat Measure Study (FARMS), A survey to establish the utility of the FUNCAP-27 for serial measurements in Myalgic Encephalomyelitis, Chronic Fatigue Syndrome (ME/CFS) and Long Covid

ME/CFS (Myalgic Encephalomyelitis / Chronic Fatigue Syndrome)
The University of Melbourne1,000 enrolled1 locationACTRN12624001479594
Recruiting

Electro-Magnetic-Frequency Therapy (EMF) for Chronic Fatigue

Viral Reactivation with Cyto-Megalo-Virus (CMV)Viral Reactivation with Herpes Simplex Virus (HSV)Viral Reactivation with Epstein-Barr Virus (EBV)+1 more
AProf Dr Karin Ried100 enrolled1 locationACTRN12624000178549
Recruiting
Phase 2

Investigation of Treating Chronic Fatigue Syndrome After COVID With Pharmacotherapy (Pregabalin) or Complex Rehabilitation

Chronic Fatigue SyndromeCOVID-19, Long Haul
National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland132 enrolled1 locationNCT05967052