Chronic Migraine Clinical Trials

28 recruiting

Chronic Migraine Trials at a Glance

32 actively recruiting trials for chronic migraine are listed on ClinicalTrialsFinder across 6 cities in 36 countries. The largest study group is Not Applicable with 13 trials, with the heaviest enrollment activity in Pavia, Wroclaw, and Madrid. Lead sponsors running chronic migraine studies include IRCCS National Neurological Institute "C. Mondino" Foundation, AbbVie, and St. Olavs Hospital.

Browse chronic migraine trials by phase

Treatments under study

About Chronic Migraine Clinical Trials

Looking for clinical trials for Chronic Migraine? There are currently 28 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Chronic Migraine trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Chronic Migraine clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 32 trials

Recruiting
Phase 2

Cannabis for the Prophylactic Treatment of Migraine

Chronic Migraine
University of Calgary72 enrolled1 locationNCT03972124
Recruiting
Phase 3

A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine

Chronic Migraine
Merz Therapeutics GmbH780 enrolled106 locationsNCT07018713
Recruiting
Phase 3

A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years

Chronic Migraine
AbbVie420 enrolled61 locationsNCT06810505
Recruiting
Not Applicable

New Methods for Evaluating Preventive Migraine Treatment

MigraineHeadache DisordersChronic Migraine, Headache+1 more
University of Aarhus60 enrolled2 locationsNCT07071506
Recruiting
Not Applicable

The RECLAIM Study.

Chronic MigraineHigh Frequency Episodic Migraine
Salvia BioElectronics110 enrolled11 locationsNCT06450444
Recruiting
Phase 3

A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic Migraine

Chronic Migraine in Children
H. Lundbeck A/S285 enrolled84 locationsNCT04965675
Recruiting
Phase 2

A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in Adults

Chronic MigraineEpisodic Migraine
Ipsen641 enrolled166 locationsNCT06625060
Recruiting
Not Applicable

Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in Vivo)

Chronic Migraine
University of Michigan80 enrolled1 locationNCT05769348
Recruiting

Post-Marketing Study to Assess the Safety and Effectiveness of Oral Atogepant in Korean Adult Participants for the Prevention of Chronic or Episodic Migraine

MigraineChronic MigraineEpisodic Migraine
AbbVie3,000 enrolled4 locationsNCT06603558
Recruiting
Not Applicable

Laser Acupuncture for Chronic Migraine

Chronic Migraine
Taichung Veterans General Hospital60 enrolled1 locationNCT06219694
Recruiting
Not Applicable

Acceptance and Commitment Therapy to Improve Disability in Chronic Migraine

Chronic Migraine
Brigham and Women's Hospital40 enrolled1 locationNCT06795867
Recruiting
Not Applicable

Determining the Utility of a Behavioral Intervention in Chronic Migraine

MigraineChronic MigraineLifestyle Factors+3 more
Mayo Clinic60 enrolled1 locationNCT05415020
Recruiting

Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA

Failed Back Surgery SyndromePost Operative PainChronic Low-back Pain+12 more
Brown University800 enrolled1 locationNCT05754190
Recruiting

Real-world Prospective Study on the Use of Anti-CGRP Drugs in Migraine

MigraineEpisodic MigraineChronic Migraine, Headache
Hospital Universitari Vall d'Hebron Research Institute700 enrolled26 locationsNCT07159750
Recruiting

Effectiveness and Impact on the Quality of Life of Ketogenic Diet in Pediatric Patients

Autism Spectrum DisorderDrug Resistant EpilepsyChronic Migraine+1 more
Danone Nutricia SpA Società Benefit100 enrolled3 locationsNCT06309251
Recruiting

i-NEED: NEw migrainE Drugs Database

Chronic MigraineEpisodic Migraine
IRCCS San Raffaele Roma2,641 enrolled1 locationNCT07103694
Recruiting

Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics

Chronic MigraineChronic Daily Headache
Stanford University700 enrolled1 locationNCT03231241
Recruiting
Phase 2

Prophylactic Treatment With Atorvastatin for Chronic Migraine (ChronicStatinMig)

Chronic Migraine
St. Olavs Hospital300 enrolled6 locationsNCT06485336
Recruiting
Not Applicable

A Study Investigating Peripheral Cryoneurolysis in Adults With Chronic Migraine

Chronic Migraine
St. Olavs Hospital12 enrolled1 locationNCT06554886
Recruiting
Phase 2

Cannabis for Chronic Headaches in Adolescents: the CAN-CHA Trial

Chronic Migraine
University of Manitoba20 enrolled3 locationsNCT05337033