Chronic Migraine Clinical Trials

44 recruitingLast updated: June 18, 2026

There are 44 actively recruiting chronic migraine clinical trials across 37 countries. Studies span Not Applicable, Phase 3, Phase 2, Early Phase 1. Top locations include Pavia, Italy, Cincinnati, Ohio, United States, Madrid, Spain. Updated daily from ClinicalTrials.gov.


Chronic Migraine Trials at a Glance

44 actively recruiting trials for chronic migraine are listed on ClinicalTrialsFinder across 6 cities in 37 countries. The largest study group is Not Applicable with 19 trials, with the heaviest enrollment activity in Pavia, Cincinnati, and Madrid. Lead sponsors running chronic migraine studies include IRCCS National Neurological Institute "C. Mondino" Foundation, University of Florence, and AbbVie.

Browse chronic migraine trials by phase

Treatments under study

About Chronic Migraine Clinical Trials

Looking for clinical trials for Chronic Migraine? There are currently 32 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Chronic Migraine trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Chronic Migraine clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 44 trials

Recruiting
Not Applicable

Mind Body Balance for Pediatric Migraine

Migraine with auraMigraineChronic Migraine+5 more
Children's Hospital Medical Center, Cincinnati260 enrolled2 locationsNCT04715685
Recruiting
Not Applicable

Ultrasound Guided Infratemporal Sphenopalatine Ganglion Supravoltage Versus Standard Voltage Pulsed Radiofrequency for Pain Alleviation in Chronic Refractory Migraine.

Chronic Migraine, Headache
Minia University100 enrolled2 locationsNCT07500558
Recruiting
Phase 3

A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic Migraine

Chronic Migraine in Children
H. Lundbeck A/S285 enrolled84 locationsNCT04965675
Recruiting

i-NEED: NEw migrainE Drugs Database

Chronic MigraineEpisodic MigraineMedication-overuse Headache
IRCCS San Raffaele Roma2,641 enrolled2 locationsNCT07103694
Recruiting
Not Applicable

Determining the Utility of a Behavioral Intervention in Chronic Migraine

MigraineChronic MigraineLifestyle Factors+3 more
Mayo Clinic60 enrolled1 locationNCT05415020
Recruiting
Phase 3

A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years

Chronic Migraine
AbbVie420 enrolled64 locationsNCT06810505
Recruiting

The Neuroanatomical and Psychological Correlates of Suggestibility in Patients With Non-Responsive Chronic Migraine

Chronic Migraine, Headache
Istituto per la Ricerca e l'Innovazione Biomedica200 enrolled1 locationNCT07617441
Recruiting

Post-Marketing Study to Assess the Safety and Effectiveness of Oral Atogepant in Korean Adult Participants for the Prevention of Chronic or Episodic Migraine

MigraineChronic MigraineEpisodic Migraine
AbbVie3,000 enrolled4 locationsNCT06603558
Recruiting
Not Applicable

New Methods for Evaluating Preventive Migraine Treatment

MigraineHeadache DisordersChronic Migraine, Headache+1 more
University of Aarhus60 enrolled2 locationsNCT07071506
Recruiting
Phase 3

A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine

Chronic Migraine
Merz Therapeutics GmbH780 enrolled108 locationsNCT07018713
Recruiting
Not Applicable

Study on 30 Outpatients With Chronic Migraine Treated With Well-Being Therapy or With a Control Therapy

Chronic Migraine
University of Florence30 enrolled2 locationsNCT03404336
Recruiting
Phase 2

A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in Adults

Chronic MigraineEpisodic Migraine
Ipsen641 enrolled166 locationsNCT06625060
Recruiting
Not Applicable

Bilateral Embolization of the Middle Meningeal Arteries for Refractory Chronic Migraine

MigraineChronic Migraine, HeadacheRefractory Migraine
Johns Hopkins University13 enrolled1 locationNCT07223008
Recruiting
Phase 2

Cannabis for the Prophylactic Treatment of Migraine

Chronic Migraine
University of Calgary72 enrolled1 locationNCT03972124
Recruiting
Not Applicable

The RECLAIM Study.

Chronic MigraineHigh Frequency Episodic Migraine
Salvia BioElectronics110 enrolled11 locationsNCT06450444
Recruiting
Not Applicable

Responding With Evidence and Access for Childhood Headaches

Migraine with auraMigraineChronic Migraine+5 more
Children's Hospital Medical Center, Cincinnati400 enrolled15 locationsNCT05889624
Recruiting
Not Applicable

Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in Vivo)

Chronic Migraine
University of Michigan80 enrolled1 locationNCT05769348
Recruiting

Gepant treAtments: EffectIveNess and tolERability (GAINER)

Migraine with auraMigraineChronic Migraine+1 more
University of Florence100 enrolled2 locationsNCT05903027
Recruiting
Not Applicable

Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Chronic Migraine

myofascial trigger pointsChronic Migraine, HeadacheGreater Occipital Nerve Block
Beijing Tiantan Hospital1,036 enrolled1 locationNCT07347067
Recruiting
Not Applicable

Laser Acupuncture for Chronic Migraine

Chronic Migraine
Taichung Veterans General Hospital60 enrolled1 locationNCT06219694