Phase 2 Cognitive Decline Clinical Trials

14 recruitingPhase 2

What is a Phase 2 trial?

Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.

Showing 114 of 14 trials

Recruiting
Phase 1Phase 2

FACE Phase II (a Stage II Trial)

MCIMild Behavioral ImpairmentSubjective Cognitive Decline (SCD)
Stanford University80 enrolled1 locationNCT07130669
Not Yet Recruiting
Phase 2

Cannabidiol and vitamin E on blood flow in the brain of older adults

Cognitive Decline
University of Southern Queensland80 enrolled1 locationACTRN12626000337370
Recruiting
Phase 2

Daridorexant to Prevent Post-cardiotomy Delirium

Postoperative DeliriumPostoperative Cognitive Decline
University of Rochester80 enrolled1 locationNCT07217912
Recruiting
Phase 1Phase 2

RAGE Inhibition to Decrease Cardiotoxicity in Women With Early Breast Cancer

Cancer Related Cognitive DeclineNon-metastatic Breast Cancer
Georgetown University48 enrolled3 locationsNCT05256745
Recruiting
Phase 2

Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot Study

Older AdultsCognitive DeclineAging+1 more
Washington University School of Medicine20 enrolled1 locationNCT07000734
Recruiting
Phase 2

Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer

Breast CancerBreast Cancer Stage IBreast Cancer Stage II+5 more
UNC Lineberger Comprehensive Cancer Center90 enrolled1 locationNCT06727773
Recruiting
Phase 2

Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study)

HypertensionSubjective Cognitive DeclineCognitively Normal Older Adults+1 more
Rong Zhang180 enrolled1 locationNCT05331144
Recruiting
Phase 2

Fasudil Trial for Treatment of Early Alzheimer's Disease (FEAD)

Alzheimer DiseaseCognitive Decline, Mild
Helse Stavanger HF200 enrolled6 locationsNCT06362707
Recruiting
Phase 2

Lithium Treatment to Prevent Cognitive Impairment After Brain Radiotherapy

Radiotherapy Side EffectCognitive ImpairmentBrain Tumor+4 more
Region Stockholm84 enrolled2 locationsNCT06051240
Recruiting
Phase 2Phase 3

GnRH Therapy on Cognition in Down Syndrome

Cognitive DeclineAlzheimer Disease, Early OnsetDown Syndrome+1 more
Nelly Pitteloud56 enrolled1 locationNCT04390646
Recruiting
Phase 2

METformin and FINGER Intervention to Prevent Cognitive Impairment and Disability in Older Adults at Risk for Dementia

Cognitive ImpairmentDementiaCognitive Decline
Imperial College London600 enrolled3 locationsNCT05109169
Not Yet Recruiting
Phase 2

A clinical trial of a prebiotic powder for symptoms of Parkinson’s disease

Parkinson's disease (constipation and cognitive decline)
University of Newcastle180 enrolled2 locationsACTRN12623001186640
Completed
Phase 2

A randomised study with placebo control to assess the effects of Ergothioneine (ERG-001) on Cognition, Mood and Sleep in both adult men and woman aged between 55 and 79 years of age.

Cognitive Decline
Blue California Ingredients150 enrolled1 locationACTRN12621001607864
Completed
Phase 2

Evaluating the relationship between response to an olfactory stress test and level of cognitive decline in older adults.

Cognitive Impairment, Cognitive decline
Dr. Peter Schofield279 enrolled2 locationsACTRN12617000273381