Phase 3 Cognitive Clinical Trials
33 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–20 of 33 trials
Recruiting
Phase 3
Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour
Cognitive ImpairmentMedulloblastoma, Childhood
Donald Mabbott140 enrolled20 locationsNCT05230758
Recruiting
Phase 3
A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)
DementiaBrain DiseasesCentral Nervous System Diseases+6 more
Eli Lilly and Company1,500 enrolled141 locationsNCT05508789
Recruiting
Phase 3
GLP-1/GCG Dual Agonist in Type 2 Diabetes With Early Dementia (LIGHT-COG Study)
Type 2 DiabetesDementia, MildMild Cognitive Impairment
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School420 enrolled8 locationsNCT07083154
Recruiting
Phase 3
A Study Evaluating the Efficacy of Xanomeline/Trospium (XT) on Cognitive Impairment After 24 and 52 Weeks of Treatment in Adult Participants With Schizophrenia
Cognitive ImpairmentSchizophrenia; Psychosis
European Group for Research In Schizophrenia171 enrolled16 locationsNCT07084831
Recruiting
Phase 3
Evaluate the Use of [18F]-APN-1607 PET in Subjects With AD-related Cognitive Impairment and Subjects With Normal Cognitive Function
Subjects With Mild Cognitive Impairment (MCI) of AD, Alzheimer's Disease (AD) Dementia
JYAMS PET Research & Development Limited316 enrolled2 locationsNCT07422857
Recruiting
Phase 3
Biomarker Exploration in Aging, Cognition and Neurodegeneration
Cognitive ImpairmentCognitive DeclineAlzheimer Disease
University of California, Irvine300 enrolled1 locationNCT03860857
Recruiting
Phase 3
PET Imaging Tau Accumulation in FTLD and Atypical Alzheimer's Using [18F]-PI-2620
Alzheimer DiseaseFrontotemporal Lobar DegenerationCognitively Normal
University of Pennsylvania72 enrolled1 locationNCT05456503
Recruiting
Phase 3
Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery
Postoperative Pain ManagementPostoperative Cognitive DysfunctionHip Fracture+1 more
Romanian Society for Enteral and Parenteral Nutrition120 enrolled1 locationNCT07113483
Recruiting
Phase 2Phase 3
MitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction
Cognitive ImpairmentMitochondrial AlterationSchizophrenia and Related Disorders
Mclean Hospital100 enrolled3 locationsNCT06191965
Recruiting
Phase 3
Cilostazol-Ginkgo for Cognitive Function in Elderly Diabetes
Type 2 Diabets MellitusCognitive Ability, General
Seoul National University Bundang Hospital80 enrolled1 locationNCT06989697
Recruiting
Phase 3
Evaluation of Memantine in the Preservation of Memory and Neurocognition Following CSI
Neurocognitive Dysfunction
Tata Memorial Centre101 enrolled1 locationNCT06275035
Recruiting
Phase 3
Polypill and RiscOMeter to Prevent StrOke and CogniTive ImpairmEnt (PROMOTE)
Cognitive DeclineStroke
Hospital Moinhos de Vento8,518 enrolled2 locationsNCT05155137
Recruiting
Phase 3
Preventing Alzheimer's With Cognitive Training
Age-related Cognitive DeclineAlzheimer's Disease and Related Dementias
University of South Florida7,600 enrolled7 locationsNCT03848312
Recruiting
Phase 3
Effect of Butyphthalide on Cognitive Level Change After Cerebral Vascular Event-a Randomized Control Trial (Be-CLEVER)
StrokePost-stroke Cognitive Impairment (PSCI)
Fudan University3,200 enrolled1 locationNCT05976152
Recruiting
Phase 2Phase 3
GnRH Therapy on Cognition in Down Syndrome
Cognitive DeclineAlzheimer Disease, Early OnsetDown Syndrome+1 more
Nelly Pitteloud56 enrolled1 locationNCT04390646
Terminated
Phase 3
Action To promote brain HEalth iN Adults (ATHENA) trial: a pilot feasibility study to determine the effects of blood pressure lowering treatment provided by a Triple Pill strategy for attenuation of cognitive decline in participants at risk for dementia.
Cognitive ImpairmentCognitive DysfunctionHypertension+1 more
The George Institute for Global Health200 enrolled1 locationACTRN12621000121864
Active
Phase 3
Benefits and safety of IRon supplementation with MAlaria chemoprevention to children in Malawi (IRMA) - A randomised controlled trial
Impaired child cognitive developmentStuntingMalaria+2 more
College of Medicine, University of Malawi2,168 enrolled1 locationACTRN12620000386932
Not Yet Recruiting
Phase 3
Better ways of pain management in adults with hip fractures
Cognitive ImpairmentHip Fracture Pain Management
Townsville Hospital122 enrolled3 locationsACTRN12618001884291
Terminated
Phase 3
Comparison of standard current anaesthetics with Phaxan™, a new intravenous anaesthetic, for efficacy, safety profile and preservation of brain function after hip replacement surgery.
Decreased cognitive function after anaesthesia and hip surgeryCardiovascular complications of anaesthetics
Drawbridge Pharmaceuticals Pty Ltd40 enrolled1 locationACTRN12618000064202
Completed
Phase 3
Effects of 4 weeks supplementation with a multi-vitamin/mineral preparation on neurocognitive function in healthy adults
Cognitive FunctionMood
Swinburne University130 enrolled1 locationACTRN12617000305325