Phase 1 coma Clinical Trials
187 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 187 trials
Recruiting
Phase 1
A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing
Locally Advanced Hepatocellular CarcinomaLocally Advanced MelanomaMetastatic Hepatocellular Carcinoma+7 more
National Cancer Institute (NCI)30 enrolled1 locationNCT06066138
Recruiting
Phase 1
IDOV-Immune for Advanced Solid Tumors
Breast CancerColorectal, CancerEsophageal Cancer+13 more
ViroMissile, Inc.78 enrolled5 locationsNCT06910657
Recruiting
Phase 1Phase 2
PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors
Refractory NeuroblastomaRefractory RhabdomyosarcomaRefractory Solid Tumors+3 more
Theodore Laetsch59 enrolled7 locationsNCT06721689
Recruiting
Phase 1Phase 2
Domatinostat With Sirolimus for Relapsed, Refractory Sarcoma and Osteosarcoma
SarcomaOsteosarcoma
H. Lee Moffitt Cancer Center and Research Institute74 enrolled4 locationsNCT07725380
Recruiting
Phase 1
Phase 1a/b Study of ZL-6201 Safety, PK, and Preliminary Efficacy in Sarcoma and Selected Tumors
Solid TumorsSarcomas
Zai Lab (Shanghai) Co., Ltd.180 enrolled8 locationsNCT07374848
Recruiting
Phase 1
FGFR4 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory Rhabdomyosarcoma
Rhabdomyosarcoma
National Cancer Institute (NCI)50 enrolled1 locationNCT06865664
Recruiting
Phase 1
Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ...
SarcomaPrecursor Cell Lymphoblastic Leukemia-LymphomaNeurofibroma, Plexiform+1 more
National Cancer Institute (NCI)54 enrolled1 locationNCT02390752
Recruiting
Phase 1
NKG2D.Zeta-NK Cell Conditioning With C7R.GD2.CAR-T Cells for Patients With Relapsed or Refractory Osteosarcoma or Neuroblastoma
Refractory OsteosarcomaRefractory NeuroblastomaRelapsed Neuroblastoma+1 more
Baylor College of Medicine27 enrolled1 locationNCT07211737
Recruiting
Phase 1Phase 2
PDS01ADC Monotherapy and in Combination With M7824 in Advanced Kaposi Sarcoma
Kaposi Sarcoma
National Cancer Institute (NCI)80 enrolled1 locationNCT04303117
Recruiting
Phase 1
Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization
Soft Tissue SarcomaMelanoma
University of Florida18 enrolled1 locationNCT05264974
Recruiting
Phase 1Phase 2
Trastuzumab Deruxtecan (DS-8201a) for the Treatment of Recurrent or Refractory Osteosarcoma, Wilms Tumor, and Desmoplastic Small Round Cell Tumor
OsteosarcomaRecurrent OsteosarcomaWilms Tumor+5 more
National Cancer Institute (NCI)55 enrolled28 locationsNCT04616560
Recruiting
Phase 1Phase 2
STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants With Selected Sarcomas
SarcomaSolid TumorLeiomyosarcoma+1 more
STORM Therapeutics LTD107 enrolled9 locationsNCT06975293
Recruiting
Phase 1
ERAS-801 for the Treatment of Resectable and Progressive or Recurrent or Elderly Newly Diagnosed IDH Wildtype Grade IV Glioblastoma or Gliosarcoma With an EGFR Amplification or Mutation, ERAS801-SARG Trial
GlioblastomaGlioblastoma, IDH-wildtypeRecurrent Glioblastoma, IDH-Wildtype+3 more
Jonsson Comprehensive Cancer Center50 enrolled2 locationsNCT07089641
Recruiting
Phase 1
Immunotherapy (Nivolumab and Ipilimumab) With and Without a Live Biotherapeutic Product (EXL01) for the Treatment of Metastatic Renal Cell Cancer
Stage III Renal Cell Cancer AJCC v8Stage IV Renal Cell Cancer AJCC v8Metastatic Clear Cell Renal Cell Carcinoma+3 more
City of Hope Medical Center33 enrolled2 locationsNCT07128680
Recruiting
Phase 1
Evaluation of Xaluritamig in Adults, Adolescents and Children With Relapsed or Refractory Ewing Sarcoma (EWS)
Ewing Sarcoma
Amgen50 enrolled8 locationsNCT07297979
Recruiting
Phase 1
Phase I CB-NK-TGF-ßR2-/NR3C1- in rGBM
Recurrent Supratentorial GlioblastomaSupratentorial GliosarcomaRecurrent Gliosarcoma
M.D. Anderson Cancer Center25 enrolled1 locationNCT04991870
Recruiting
Phase 1
A Phase I Study of Pazopanib in Combination With Trabectedin, Ipilimumab and Nivolumab (TraPIN) in Pediatric and Young Adult Patients With Recurrent Soft Tissue Sarcomas
Soft Tissue Sarcomas
M.D. Anderson Cancer Center18 enrolled1 locationNCT07444619
Recruiting
Phase 1Phase 2
Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies
Triple-Negative Breast CancerOvarian CancerCervical Cancer+3 more
University of California, Irvine67 enrolled1 locationNCT07064018
Recruiting
Phase 1
MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma
Recurrent GlioblastomaRecurrent Malignant GliomaRecurrent Gliosarcoma+2 more
M.D. Anderson Cancer Center36 enrolled1 locationNCT03896568
Recruiting
Phase 1
Actinium Therapy for Late-stage Aggressive Sarcomas
Advanced Soft Tissue Sarcoma
Ratio Therapeutics, Inc.30 enrolled6 locationsNCT07156565