Complex regional pain syndrome Clinical Trials

23 recruitingLast updated: May 13, 2026

There are 23 actively recruiting complex regional pain syndrome clinical trials across 10 countries. Studies span Not Applicable, Phase 1, Phase 2, Phase 3. Top locations include Cincinnati, Ohio, United States, La Jolla, California, United States, Bari, Italy. Updated daily from ClinicalTrials.gov.


Complex regional pain syndrome Trials at a Glance

23 actively recruiting trials for complex regional pain syndrome are listed on ClinicalTrialsFinder across 6 cities in 10 countries. The largest study group is Not Applicable with 15 trials, with the heaviest enrollment activity in Cincinnati, La Jolla, and Bari. Lead sponsors running complex regional pain syndrome studies include Children's Hospital Medical Center, Cincinnati, Stanford University, and Avigen, Inc..

Browse complex regional pain syndrome trials by phase

Treatments under study

About Complex regional pain syndrome Clinical Trials

Looking for clinical trials for Complex regional pain syndrome? There are currently 6 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Complex regional pain syndrome trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Complex regional pain syndrome clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 23 trials

Recruiting
Not Applicable

Prednisone for CRPS in Distal Radius Fracture

Distal Radius FracturesComplex Regional Pain Syndromes
University of British Columbia40 enrolled1 locationNCT06453447
Recruiting
Phase 3

Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE)

Complex Regional Pain Syndrome Type I
Ambros Therapeutics, Inc.270 enrolled6 locationsNCT07210515
Recruiting

Peripersonal Space Representation in Upper Limb Segmental Exclusion

Segmental Exclusion SyndromeComplex Regional Pain Syndrome (CRPS)Upper Limb Neglect (Peripheral)
Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est60 enrolled1 locationNCT07349173
Recruiting
Not Applicable

Perineural Incobotulinumtoxin-A for Complex Regional Pain Syndrome - An Open-label Feasibility Study

CRPS (Complex Regional Pain Syndromes)CRPS (Complex Regional Pain Syndrome) Type ICRPS Type II
Bo Biering-Soerensen20 enrolled1 locationNCT07473635
Recruiting
Not Applicable

Contribution of Immersive Virtual Reality to a Standardized Rehabilitation Program for Upper Limb Chronic Pain: A Single-Case Experimental Design Study

Complex Regional Pain Syndrome Type I of the Upper Limb
University Hospital, Angers12 enrolled2 locationsNCT06523361
Recruiting
Not Applicable

Intermittent Dosing of Dorsal Root Ganglion Stimulation as an Alternate Paradigm to Continuous Low-Frequency Therapy

Peripheral NeuropathyCRPS (Complex Regional Pain Syndromes)radiculopathy
Rush University Medical Center30 enrolled1 locationNCT04909138
Recruiting
Not Applicable

Pulsed Electromagnetic Fields (PEMFS) in Complex Regional Pain Syndrome Type i (CRPS-I) of the Foot (PeCFoA)

Foot DiseasesComplex Regional Pain SyndromesPain, Joint+1 more
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari28 enrolled1 locationNCT05922618
Recruiting

Infrared Images for Spinal Cord Stimulation in Complex Regional Pain Syndrome Patients

Complex Regional Pain Syndromes
Hospital for Special Surgery, New York12 enrolled1 locationNCT05777889
Recruiting

Role of the Gut Microbiome in Complex Regional Pain Syndrome

Complex Regional Pain Syndromes
Washington University School of Medicine140 enrolled1 locationNCT03612193
Recruiting
Not Applicable

Closed Loop Spinal Cord Stimulation for Complex Regional Pain Syndrome

Complex Regional Pain Syndromes
Scripps Health32 enrolled1 locationNCT06421350
Recruiting
Not Applicable

Impact of Compression Garments on Pain in Patients With Complex Regional Pain Syndrome of the Upper Limbs.

Complex Regional Pain Syndromes
Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape60 enrolled1 locationNCT05034835
Recruiting
Not Applicable

The Effectiveness of Conservative Treatment in Patients With Complex Regional Pain Syndrome.

CRPS (Complex Regional Pain Syndromes)
Oulu University Hospital156 enrolled1 locationNCT07208825
Recruiting
Not Applicable

Non Invasive Neurostimulation Technology for the Treatment of Type I Complex Regional Pain Syndrome (CRPS I)

Type I Complex Regional Pain Syndrome
University of Las Palmas de Gran Canaria42 enrolled1 locationNCT05052736
Recruiting
Not Applicable

Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain

Post-herpetic neuralgiaPain, PostoperativeNerve Injury+6 more
University of California, San Francisco12 enrolled1 locationNCT04144972
Recruiting
Not Applicable

Supraspinal Processing of Sensory Aspects of Pain

Musculoskeletal PainFibromyalgiaFunctional Abdominal Pain Syndrome+2 more
Children's Hospital Medical Center, Cincinnati350 enrolled1 locationNCT05814497
Recruiting
Not Applicable

Low-Dose Naltrexone for the Treatment of Complex Regional Pain Syndrome

Complex regional pain syndrome
Stanford University120 enrolled1 locationNCT02502162
Recruiting
Not Applicable

TMS for Complex Regional Pain Syndrome

Complex Regional Pain Syndromes
Stanford University40 enrolled1 locationNCT03137472
Recruiting
Not Applicable

Evaluation of the Relationship Between the Duration of the Evolution of the Complex Regional Pain Syndrome Type 1 (CRPS 1) and Effectiveness of the Continuous Peripheral Nerve Block (CPNB) Associated With an Intensive Rehabilitation Program

CRPS (Complex Regional Pain Syndrome) Type I
Pôle Saint Hélier30 enrolled1 locationNCT04767646
Recruiting
Not Applicable

The Effects of Whirlpool and Contrast Bath in Patients with Complex Regional Pain Syndrome After Distal Radius Fracture

Complex regional pain syndromeDistal Radius FractureComplex Regional Pain Syndrome Type I
Afyonkarahisar Health Sciences University40 enrolled1 locationNCT06769373
Recruiting
Phase 1

The Effects and Mechanisms of a High CBD Cannabis Extract (BRC-002) for the Treatment of Pain and Health in Complex Regional Pain Syndrome

Complex regional pain syndrome
University of California, San Diego52 enrolled2 locationsNCT06393101