RecruitingNCT06596746

Neurodegenerative Diseases Progression Markers (MARKERS-NDD)

Neurodegenerative Diseases Progression Markers (MARKERS-NDD): a Real-world Data Longitudinal Prospective Study

Sponsor

Casa di Cura San Raffaele Cassino

Enrollment

600 participants

Start Date

Sep 9, 2024

Study Type

OBSERVATIONAL

Conditions

Cognitive Impairment Dementia Multiple System Atrophy Movement Disorders Amyotrophic Lateral Sclerosis Alzheimer Disease Parkinson Disease Corticobasal Degeneration Lewy Body Disease Neurodegenerative Diseases Frontotemporal Lobar Degeneration TDP-43 Proteinopathies Tauopathies Atypical Parkinsonism Synucleinopathies Supranuclear Palsy, Progressive Iron Overload Neurodegeneration With Brain Iron Accumulation (NBIA)

Summary

MARKERS-NDD is a prospective, observational, longitudinal study, which aims to collect data from patients affected by neurodegenerative diseases (NDD) followed longitudinally for routine examinations performed as part of normal clinical practice. Data collected from clinical evaluations, movement analysis, brain imaging, neuropsychological and electroencephalographic assessments, blood chemistry tests will be analysed to carry out statistical investigations and predictive analyses, also using artificial intelligence systems, which allow the identification of new early markers of diagnosis and prognosis of neurodegenerative diseases.

Eligibility

Min Age: 10 Years

Inclusion Criteria15

Patients with diagnosis of Parkinson's Disease, Parkinsonism and Movement Disorders
Patients with diagnosis of Parkinson's Disease
Diagnosis of Parkinson's Disease according to the United Kingdom (UK) Parkinson's Disease Society Brain Bank
Diagnosis of Movement Disorder not related to Parkinson's Disease
Diagnosis of Multiple System Atrophy (MSA) in accordance with Second Consensus Statement on Diagnosis of Multiple System Atrophy;
Diagnosis of Progressive Supranuclear Palsy according to Movement Disorder Society for Diagnosis of Progressive Supranuclear Palsy;
Diagnosis of Essential Tremor
Willing to participate in the study, understand the procedures and sign the informed consent.
Patients affected by cognitive impairment (CI) and dementia
Diagnosis of probable:
Lewy Body Dementia
Alzheimer's Disease
Mild Cognitive Decline
Subjective memory complaints
Willing to participate in the study, understand the procedures and sign the informed consent.

Exclusion Criteria1

There are no restrictions for participation in the study based on age, severity of illness or presence of cognitive impairment, as long as the person is able to complete the research assessments.