Spondylolisthesis Clinical Trials

28 recruitingLast updated: June 15, 2026

There are 28 actively recruiting spondylolisthesis clinical trials across 14 countries. Studies span Not Applicable, Phase 1, Phase 2, Phase 4. Top locations include Atlanta, Georgia, United States, Aurora, Colorado, United States, Austin, Texas, United States. Updated daily from ClinicalTrials.gov.


Spondylolisthesis Trials at a Glance

28 actively recruiting trials for spondylolisthesis are listed on ClinicalTrialsFinder across 6 cities in 14 countries. The largest study group is Not Applicable with 12 trials, with the heaviest enrollment activity in Atlanta, Aurora, and Austin. Lead sponsors running spondylolisthesis studies include Assistance Publique - Hôpitaux de Paris, Beijing Friendship Hospital, and Alphatec Spine, Inc..

Browse spondylolisthesis trials by phase

Treatments under study

About Spondylolisthesis Clinical Trials

Looking for clinical trials for Spondylolisthesis? There are currently 14 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Spondylolisthesis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Spondylolisthesis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 28 trials

Recruiting

PMCF Study on the Effectiveness and Safety of METROSAN Spinal Systems and BONEGRAFT Filling Materials

SpondylolisthesisSpinal StenosisSpinal Tumors+5 more
Metrosan End. ve Elk. Mek. Cihazlar ve Tibbi Malz. San. Tic. Ltd. Co.561 enrolled3 locationsNCT07615491
Recruiting

Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery

Lumbar Spinal StenosisLumbar Disc Herniation With RadiculopathyLumbar Degenerative Spondylolisthesis+1 more
Marmara University75 enrolled1 locationNCT07489001
Recruiting
Not Applicable

Studying Melatonin and Recovery in Teens

SpondylolisthesisScoliosis; AdolescenceScoliosis Idiopathic+5 more
Stanford University45 enrolled1 locationNCT06093477
Recruiting

Advanced SPinal Innovations With Robotics and Enabling Technology Registry

SpondylolisthesisAdolescent Idiopathic ScoliosisCongenital Scoliosis+3 more
Boston Children's Hospital700 enrolled10 locationsNCT05071144
Recruiting
Phase 4

Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery

Lumbar RadiculopathyDegenerative Disc DiseaseLumbar Spinal Stenosis+7 more
John O'Toole125 enrolled1 locationNCT05029726
Recruiting

Adult Patient Outcomes After Spine Surgery With Fibergraft BG Putty/Viper Prime

Spondylolisthesis, Lumbar RegionSpinal Trauma With Neurological DeficitDegeneration of Lumbar Intervertebral Disc
Nitin Agarwal100 enrolled1 locationNCT06704906
Recruiting

Clinical Study on the Therapeutic Efficacy of Biportal Endoscopic Decompression Spine Surgery and Lumbar Decompression Fusion Surgery in the Treatment of Degenerative Lumbar Spondylolisthesis

Lumbar Degenerative Spondylolisthesis
The Fourth Affiliated Hospital of Zhejiang University School of Medicine100 enrolled1 locationNCT07289737
Recruiting

Thoracic-Lumbar Arthrodesis- Implanet Jazz

SpondylolisthesisSpinal StenosisDegenerative disease
Francis Farhadi300 enrolled1 locationNCT05366140
Recruiting
Not Applicable

Post-Market Clinical Study of Functional Motion Outcomes in Subjects Treated With the Minuteman Device

SpondylolisthesisLumbar Spinal StenosisDegenerative Conditions of the Lumbar Spine
Spinal Simplicity LLC150 enrolled6 locationsNCT06355791
Recruiting
Not Applicable

Restoring Segmental Lumbar Lordosis After Failed Previous Fusion at the Same Level

Failed Back Surgery SyndromeDegenerative SpondylolisthesisSagittal Imbalance+1 more
N.N. Priorov National Medical Research Center of Traumatology and Orthopedics20 enrolled1 locationNCT07050290
Recruiting
Not Applicable

Comparison of Radiographic Fusion Rate and Clinical Outcome of ALIF and XLIF Performed With Either Recombinant Human Bone Morphogenetic Protein-2 or ViviGen®

SpondylolisthesisDegenerative Disc DiseaseSpondylosis
Lindenhofgruppe AG168 enrolled1 locationNCT05238740
Recruiting

Effect of Degenerative Spondylolisthesis on the Clinical Outcome of Unilateral Biportal Endoscopy for Lumbar Spinal Stenosis: Study Protocol

Lumbar Spinal StenosisDegenerative Spondylolisthesis
Beijing Friendship Hospital150 enrolled1 locationNCT06394089
Recruiting

Short-term Clinical Outcome of Cortical Bone Trajectory Compared With the Traditional "Open" and Minimal Invasive Posterior Lumbar Interbody Fusion

Degenerative SpondylolisthesisSpondylolytic Spondylolisthesis
Jos M. A. Kuijlen180 enrolled1 locationNCT05538416
Recruiting

ESCAPE : Evaluation of Spinal Conservation by Endoscopic Procedures to Avoid Fusion

SpondylolisthesisSpinal Stenosis
University Hospital, Bordeaux375 enrolled13 locationsNCT06950853
Recruiting
Not Applicable

Self-rehabilitation At Home After LumbaR Arthrodesis (SAHARA)

Spondylolisthesis, Lumbar Region
Assistance Publique - Hôpitaux de Paris120 enrolled1 locationNCT06129682
Recruiting

Long-term Reoperations After Lumbar Spinal Stenosis Surgery

Degenerative Lumbar Spondylolisthesis
University Hospital of North Norway794 enrolled1 locationNCT06407063
Recruiting
Not Applicable

PREventing Pain After Surgery

SpondylolisthesisSpinal StenosisPain, Back+3 more
Brigham and Women's Hospital140 enrolled1 locationNCT05306665
Recruiting

Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion Procedure

Intervertebral disc degenerationSpondylolisthesisSpinal Instability+2 more
Alphatec Spine, Inc.400 enrolled1 locationNCT05648474
Recruiting
Phase 1Phase 2

Long-term Safety Trial with NVDX3

Distal Radius FracturesDegenerative Lumbar Spondylolisthesis
Novadip Biosciences15 enrolled1 locationNCT06532253
Recruiting
Not Applicable

Midline Versus Paramedian Approaches in Treating Degenerative Lumbar Spondylolisthesis

Spondylolisthesis, Lumbar Region
Nova Scotia Health Authority100 enrolled1 locationNCT03344484