Phase 1 Depressive Disorder Clinical Trials
23 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 23 trials
Recruiting
Phase 1Phase 2
Personalized Ultrasonic Brain Stimulation for Depression (R61)
Depression - Major Depressive DisorderMajor Depressive EpisodeTreatment-Resistant Major Depressive Disorder
Brian Mickey30 enrolled1 locationNCT06902298
Recruiting
Phase 1Phase 2
Pharmacokinetics, Safety, Tolerability and Efficacy of a Subcutaneous Long-Acting Injection of Cariprazine (Cariprazine Depot) in Subjects Eligible for Treatment With Oral Cariprazine
SchizophreniaMajor Depressive DisorderBipolar I Disorder
Mapi Pharma Ltd.24 enrolled6 locationsNCT07185815
Recruiting
Phase 1
NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits
Depressive Disorder, MajorDepressive Disorder, Treatment-Resistant
Washington University School of Medicine60 enrolled1 locationNCT02994433
Recruiting
Phase 1
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
DepressionHealthy VolunteerMajor Depressive Disorder
National Institute of Mental Health (NIMH)150 enrolled1 locationNCT03065335
Recruiting
Phase 1Phase 2
Neural Response to Inflammatory Challenge in Major Depressive Disorder
Major Depressive Disorder
Laureate Institute for Brain Research, Inc.180 enrolled1 locationNCT04751331
Recruiting
Phase 1Phase 2
Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression
Depressive Disorder
Federal University of Latin American Integration24 enrolled1 locationNCT06898606
Recruiting
Phase 1
Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic Effects
Depression - Major Depressive DisorderAnhedonia
Medical University of Vienna85 enrolled1 locationNCT07490353
Recruiting
Phase 1
Open-Label Psilocybin Study in Transdiagnostic Population
AnxietyDepression - Major Depressive DisorderPTSD+5 more
Yale University50 enrolled1 locationNCT06442423
Recruiting
Phase 1
A Study to Explore the Effect of SP-624 on Brain Network Analytics in Healthy Adults and Adults With Major Depression
DepressionHealthyMajor Depressive Disorder
Sirtsei Pharmaceuticals, Inc.36 enrolled2 locationsNCT06570369
Recruiting
Phase 1
A Brain Imaging Study to Assess the Binding of MSP-2020 to Serotonin 5-HT2A Receptors in Healthy Male Adults
Incomplete Response - Major Depressive Disorder (IR-MDD)
Otsuka Pharmaceutical Development & Commercialization, Inc.18 enrolled1 locationNCT07329621
Recruiting
Phase 1
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
DepressionMajor Depressive DisorderMajor Depression
National Institute of Mental Health (NIMH)70 enrolled1 locationNCT03973268
Recruiting
Phase 1
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
HealthyMajor Depressive DisorderTreatment Resistant Depression
Baylor College of Medicine100 enrolled2 locationsNCT06480201
Recruiting
Phase 1
Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use
Depression, AnxietyAnxietyDepression - Major Depressive Disorder+1 more
Trustees of Dartmouth College15 enrolled1 locationNCT06920238
Not Yet Recruiting
Phase 1
Testing the Safety and Effects of the Psychedelic Psilocin on Wellbeing and Anxiety in People with Ongoing Physical and Mental Health Conditions
Chronic Fatigue SyndromeAnorexia NervosaFibromyalgia+6 more
Tryptamine Therapeutics66 enrolled1 locationACTRN12625000949482
Recruiting
Phase 1Phase 2
Modulating Spinal Interoceptive Pathways to Evaluate Their Role and Therapeutic Potential in MDD Symptomatic Domains
Depression - Major Depressive Disorder
University of Cincinnati67 enrolled1 locationNCT06795451
Recruiting
Phase 1
Theta-Burst Stimulation to Treat Depression
Major Depressive Disorder (MDD)
Centre for Addiction and Mental Health84 enrolled1 locationNCT07033780
Recruiting
Phase 1Phase 2
Effects of Low-intensity Transcranial Magnetic Stimulation on Major Depressive Disorder, and on 5-hydroxyindoleacetic Acid and Brain-derived Neurotrophic Factor Levels
Depression - Major Depressive DisorderTranscranial Magnetic StimulationPlacebo
Universidad de Guanajuato40 enrolled1 locationNCT06667180
Recruiting
Phase 1
Alexithymia Intervention for Suicide
SchizophreniaPost Traumatic Stress DisorderSuicide+2 more
VA Office of Research and Development40 enrolled1 locationNCT05724953
Recruiting
Phase 1Phase 2
ANTIVIRAL TREATMENT OF CYTOMEGALOVIRUS IN DEPRESSION
Major Depressive Disorder
Laureate Institute for Brain Research, Inc.24 enrolled1 locationNCT04724447
Recruiting
Phase 1
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response
Post Traumatic Stress DisorderDepressive Disorder, Major
Yale University50 enrolled1 locationNCT05915013