Phase 2 Depressive Disorder Clinical Trials
84 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 84 trials
Recruiting
Phase 2
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
DepressionDepressive DisorderMolecular Mechanisms of Pharmacological Action+10 more
National Institute of Mental Health (NIMH)50 enrolled1 locationNCT06511908
Recruiting
Phase 2
Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV
Mild Neurocognitive DisorderMajor Depressive DisorderHIV
National Institute of Allergy and Infectious Diseases (NIAID)186 enrolled41 locationsNCT06705478
Recruiting
Phase 2
Efficacy and Safety of Sertraline Combined With Lactobacillus Crispatus in Adolescents With Depression
Major Depressive Disorder (MDD)Probiotic Intervention
First Affiliated Hospital of Chongqing Medical University60 enrolled2 locationsNCT07539805
Recruiting
Phase 2
A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
Major Depressive Disorder
AbbVie195 enrolled33 locationsNCT07276997
Recruiting
Phase 2
Sertraline Combined With Multi-Strain Probiotics for Adolescent Depression
Major Depressive Disorder (MDD)Probiotic Intervention
First Affiliated Hospital of Chongqing Medical University120 enrolled1 locationNCT07645157
Recruiting
Phase 2
Mindfulness-based Psilocybin Therapy for PTSD
Depression - Major Depressive DisorderPost Traumatic Stress Disorder
Anthony P King30 enrolled1 locationNCT07104916
Recruiting
Phase 2
ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
Major Depressive Disorder (MDD)Depressive Disorder, Treatment-Resistant
ACADIA Pharmaceuticals Inc.153 enrolled21 locationsNCT07284667
Recruiting
Phase 2
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
DepressionMajor Depressive Disorder (MDD)Major Depressive Episode (MDE)
Tonix Pharmaceuticals, Inc.360 enrolled25 locationsNCT07621237
Recruiting
Phase 2
Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders
Major Depressive DisorderAnxiety Disorders
National Institute of Mental Health (NIMH)3,500 enrolled2 locationsNCT00018057
Recruiting
Phase 2
A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
Major Depressive Disorder
Syndeio Biosciences, Inc164 enrolled32 locationsNCT07115329
Recruiting
Phase 2
Inhaled DMT for Major Depressive Disorder
SuicideSuicidal IdeationMajor Depression+2 more
Universidade Federal do Rio Grande do Norte140 enrolled5 locationsNCT07562191
Recruiting
Phase 2
Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
Major Depressive Disorder
Syndeio Biosciences, Inc164 enrolled34 locationsNCT06547489
Recruiting
Phase 2
A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
Major Depressive Disorder (MDD)
Draig Therapeutics Ltd118 enrolled2 locationsNCT07610473
Recruiting
Phase 2
Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulation
Anxiety DisorderDepressive Disorder, Major
Mclean Hospital112 enrolled1 locationNCT05232032
Recruiting
Phase 2
A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
Major Depressive Disorder (MDD)Major Depressive Disorder With Anxious Distress
Seaport Therapeutics360 enrolled59 locationsNCT07065240
Recruiting
Phase 2Phase 3
Understanding and Treating Suicidal Ideation With Ketamine
Suicidal IdeationMajor Depressive Disorder (MDD)
The Royal's Institute of Mental Health Research36 enrolled1 locationNCT06891300
Recruiting
Phase 2
Stratified Pharmacological Approaches for Regulating Circuit-Level Effects
Depression - Major Depressive Disorder
Stanford University60 enrolled1 locationNCT07022405
Recruiting
Phase 2
A Study to Explore the Efficacy of JNJ-89495120 in the Treatment of Major Depressive Disorder
Depressive Disorder, Major
Janssen Research & Development, LLC100 enrolled44 locationsNCT06785012
Recruiting
Phase 2
Lemborexant for the Treatment of Residual Insomnia in Major Depressive Disorder (MDD)
Major Depressive Disorder (MDD)Insomnia Comorbid to Psychiatric Disorder
Unity Health Toronto30 enrolled1 locationNCT06843187
Recruiting
Phase 2
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
Depressive DisorderPost Traumatic Stress DisorderSuicidal Ideation+2 more
Yale University30 enrolled1 locationNCT05786066