Phase 1 Diabetes Clinical Trials
113 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 113 trials
Recruiting
Phase 1
A Clinical Study Comparing the Relative Bioavailability and Safety of SHR-3167 Injection
Diabetes Mellitus
Jiangsu HengRui Medicine Co., Ltd.60 enrolled1 locationNCT07489482
Recruiting
Phase 1
A Single Bolus, 12-hour Euglycemic Clamp Study of the Safety, Pharmacokinetics (PK) and Glucodynamics (GD) of Intraperitoneal (IP) Portal Insulin U-500
Type 1 Diabetes
Portal Diabetes, Inc.25 enrolled1 locationNCT07341373
Recruiting
Phase 1
Investigating How NNC0487-0111 Regulates Insulin of Adults With Type 2 Diabetes
Diabetes Mellitus
Novo Nordisk A/S80 enrolled1 locationNCT07535307
Recruiting
Phase 1Phase 2
A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM
Type 2 Diabetes Mellitus (T2DM)Obese or Overweight Healthy Volunteers
Alnylam Pharmaceuticals144 enrolled20 locationsNCT06845202
Recruiting
Phase 1
A Clinical Study to Evaluate the Pharmacokinetic and Pharmacodynamics Properties of of SHR-3167 in Subjects With Type 2 Diabetes
Type 2 Diabetes
Jiangsu HengRui Medicine Co., Ltd.55 enrolled1 locationNCT07032688
Recruiting
Phase 1
A Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes
ObesityHealthyOverweight+1 more
Eli Lilly and Company216 enrolled6 locationsNCT06945419
Recruiting
Phase 1
A Study to Evaluate the Effect of Fasting Duration and Tirzepatide Withholding on the Amount of Food and Fluid in the Stomach in Participants With Type 2 Diabetes Mellitus and Participants With Overweight or Obesity Without Type 2 Diabetes Mellitus
ObesityDiabetes Mellitus, Type 2Overweight
Eli Lilly and Company40 enrolled1 locationNCT07299084
Recruiting
Phase 1
Phase I Study to Evaluate the Pharmacokinetics and Safety After Co-administration of L03RD1 and L03RD2 or Administration of L03TD1 in Healthy Volunteers
Type 2 Diabetes Mellitus (T2DM)
Celltrion48 enrolled1 locationNCT07533539
Recruiting
Phase 1Phase 2
A First-In-Human Study of ARO-ALK7 in Adults With Obesity With and Without Type 2 Diabetes Mellitus
ObesityDiabetes Mellitus, Type 2
Arrowhead Pharmaceuticals138 enrolled8 locationsNCT06937203
Recruiting
Phase 1
A Study of GNTI-122 in Adults Recently Diagnosed With T1D
Type 1 Diabetes MellitusType 1 Diabetes (T1D)
GentiBio, Inc16 enrolled10 locationsNCT06919354
Recruiting
Phase 1
Dorzagliatin in Pancreatic Insufficient Cystic Fibrosis
Cystic Fibrosis-related DiabetesPancreatic Insufficiency
University of Pennsylvania15 enrolled2 locationsNCT06995651
Recruiting
Phase 1
Cellular Therapy for Type 1 Diabetes Using Mesenchymal Stem Cells
Diabetes Mellitus, Type 1
Medical University of South Carolina60 enrolled1 locationNCT04061746
Recruiting
Phase 1Phase 2
cfMSC Therapy for Diabetes
Type II Diabetes Mellitus
Shenzhen Geno-Immune Medical Institute30 enrolled1 locationNCT07495956
Recruiting
Phase 1
Safety, Pharmacokinetics, and Pharmacodynamics of MTX-101 in Healthy Adults and Patients
Healthy VolunteersType 1 Diabetes
Mozart Therapeutics Australia Pty Ltd96 enrolled4 locationsNCT06324604
Recruiting
Phase 1
A Study of REGEND003 on Patients With Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD)
Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD)
Regend Therapeutics15 enrolled1 locationNCT07275788
Recruiting
Phase 1Phase 2
A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes
Type 1 DiabetesNew Onset
City of Hope Medical Center120 enrolled11 locationsNCT07061574
Recruiting
Phase 1
SGLT2i, Pioglitazone, and Ketone Production in T2D
Type 2 Diabetes
The University of Texas Health Science Center at San Antonio64 enrolled1 locationNCT07053319
Recruiting
Phase 1
A Study to Evaluate the Effect of RO7204239 on Insulin Sensitivity and Muscle Composition in Participants With Type 2 Diabetes Mellitus (T2DM) and Overweight or Obesity
ObesityOverweightType 2 Diabetes Mellitus
Hoffmann-La Roche30 enrolled1 locationNCT07137585
Recruiting
Phase 1
Study to Evaluate if Exposure to Drug is Impacted in Participants With Renal Insufficiency
Type II Diabetes Mellitus
Sun Pharmaceutical Industries Limited40 enrolled3 locationsNCT07385547
Recruiting
Phase 1Phase 2
Pancreatic Islet Transplantation Into the Anterior Chamber of the Eye
Diabetes
Midhat H. Abdulreda2 enrolled2 locationsNCT02846571