Phase 1 Diabetes Clinical Trials
123 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 123 trials
Recruiting
Phase 1
THC Effects on Glucose in Type 2 Diabetes
Type 2 Diabetes
University of California, San Diego30 enrolled1 locationNCT05322213
Recruiting
Phase 1Phase 2
A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM
Type 2 Diabetes Mellitus (T2DM)Obese or Overweight Healthy Volunteers
Alnylam Pharmaceuticals144 enrolled22 locationsNCT06845202
Recruiting
Phase 1
A Study of ONO-3310 in Healthy Adult Male Subjects and Chronic Kidney Disease Patients With Type 2 Diabetes Mellitus
Chronic Kidney DiseaseType2 Diabetes Mellitus
Ono Pharmaceutical Co., Ltd.120 enrolled1 locationNCT07619157
Recruiting
Phase 1
Bioavailability, Biopotency and Food Effect Study of SCD0503 Compared to Subcutaneous Regular Human Insulin
Diabetes Mellitus, Type 1
Sam Chun Dang Pharm. Co. Ltd.16 enrolled1 locationNCT07634770
Recruiting
Phase 1
A Research Study Investigating the Effect of NNC0497-0040 in Healthy Participants, Participants With Overweight or Obesity, and Participants With Type 1 Diabetes With Overweight or Obesity
ObesityHealthy VolunteersOverweight+1 more
Novo Nordisk A/S146 enrolled1 locationNCT07578584
Recruiting
Phase 1Phase 2
A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes
Type 1 DiabetesNew Onset
City of Hope Medical Center120 enrolled11 locationsNCT07061574
Recruiting
Phase 1
A Study to Evaluate the Pharmacokinetics of HRS9531 Injection in Participants With Mild, Moderate, and Normal Hepatic Function
Diabetes MellitusWeight Loss
Fujian Shengdi Pharmaceutical Co., Ltd.24 enrolled1 locationNCT07540754
Recruiting
Phase 1
A Clinical Trial of MK-1403 in Participants With Type 2 Diabetes Mellitus (MK-1403-006)
Diabetes Mellitus, Type 2
Merck Sharp & Dohme LLC52 enrolled4 locationsNCT07242469
Recruiting
Phase 1Phase 2
CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)
Type 1 DiabetesType 1 Diabetes MellitusType 1 Diabetes Mellitis+7 more
COUR Pharmaceutical Development Company, Inc.72 enrolled30 locationsNCT06783309
Recruiting
Phase 1
Study of ALV-100 to Assess Safety, Tolerability, and PK/PD in Overweight/Obese Participants With or Without T2D
Overweight or Obese AdultsOverweight or Obese, Type 2 Diabetes
Alveus Therapeutics, Inc.180 enrolled2 locationsNCT07399678
Recruiting
Phase 1
A Research Study to Evaluate the Safety of NNC1679-0001 When Given to Healthy Participants and Participants With T2DM
Diabetes Mellitus, Type 2Healthy Volunteers
Novo Nordisk A/S80 enrolled1 locationNCT07570992
Recruiting
Phase 1
A Study to Evaluate the Effect of Maridebart Cafraglutide on Insulin Sensitivity and β-cell Function in Participants With Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus
Amgen57 enrolled1 locationNCT07160257
Recruiting
Phase 1
Safety, Pharmacokinetics, and Pharmacodynamics of MTX-101 in Healthy Adults and Patients
Healthy VolunteersType 1 Diabetes
Mozart Therapeutics Australia Pty Ltd96 enrolled3 locationsNCT06324604
Recruiting
Phase 1
SGLT2i, Pioglitazone, and Ketone Production in T2D
Type 2 Diabetes
The University of Texas Health Science Center at San Antonio64 enrolled1 locationNCT07053319
Recruiting
Phase 1
A Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes
ObesityHealthyOverweight+1 more
Eli Lilly and Company216 enrolled5 locationsNCT06945419
Recruiting
Phase 1
FES Cycling With BFR in the Spinal Cord Injury Population
Spinal Cord InjuryMetabolic Diseases, Type 2 Diabetes, Cardiovascular DiseaseCardio Vascular Disease
Dr. B. Catharine. Craven6 enrolled1 locationNCT07588503
Recruiting
Phase 1
A Study of GNTI-122 in Adults Recently Diagnosed With T1D
Type 1 Diabetes MellitusType 1 Diabetes (T1D)
GentiBio, Inc16 enrolled10 locationsNCT06919354
Recruiting
Phase 1
A Phase 1, Multiple Ascending Dose Study to Evaluate HMS1005 in Participants With Type 2 Diabetes
Type 2 Diabetes
Hua Medicine Limited40 enrolled1 locationNCT07568678
Recruiting
Phase 1
A Clinical Study Comparing the Relative Bioavailability and Safety of SHR-3167 Injection
Diabetes Mellitus
Jiangsu HengRui Medicine Co., Ltd.60 enrolled1 locationNCT07489482
Recruiting
Phase 1
A Single Bolus, 12-hour Euglycemic Clamp Study of the Safety, Pharmacokinetics (PK) and Glucodynamics (GD) of Intraperitoneal (IP) Portal Insulin U-500
Type 1 Diabetes
Portal Diabetes, Inc.25 enrolled1 locationNCT07341373