Early Phase 1 Disease Clinical Trials
112 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 112 trials
Recruiting
Early Phase 1
Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease
HypopituitarismArginine vasopressin deficiencyOxytocin Deficiency+1 more
Massachusetts General Hospital20 enrolled1 locationNCT07568509
Recruiting
Early Phase 1
Cranberry and Gut Health in Crohn's Disease
Crohn DiseaseCrohn Disease (CD)
Ana Maldonado-Contreras50 enrolled1 locationNCT07170462
Recruiting
Early Phase 1
Placebo-controlled Study of Single and Multiple Ascending Doses of UDP-003 in Healthy Human Participants and Followed by an Open-label Patient Cohort
Atherosclerotic Cardiovascular DiseaseAcute Coronary Syndromes
Cyclarity Therapeutics, Inc.84 enrolled1 locationNCT06813339
Recruiting
Early Phase 1
Comparison of the Efficacy of Conventional Versus Minimally Invasive Non-Surgical Periodontal Therapy in Periodontitis Patients
Periodontal DiseaseStage III Periodontitis
Mansoura University30 enrolled1 locationNCT07671274
Recruiting
Early Phase 1
Open-label Study to Evaluate Brain α-Synuclein Deposition Using PET and [18F]MK-0947 in Parkinson's Disease
Parkinson's DiseaseParkinson's Disease (PD)Parkinson's Disease (Disorder)
Invicro22 enrolled2 locationsNCT07348250
Recruiting
Early Phase 1
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease
Peripheral arterial occlusive diseasePeripheral Arterial DiseasePeripheral Vascular Diseases+1 more
University of Nebraska20 enrolled1 locationNCT06319339
Recruiting
Early Phase 1
VTP-1000 in Adults With Celiac Disease
Celiac Disease
Barinthus Biotherapeutics45 enrolled16 locationsNCT06310291
Recruiting
Early Phase 1
FET PET/CT Imaging To Localize Pituitary Adenomas In Cushing Disease
Pituitary AdenomaCushing Disease
Mayo Clinic50 enrolled1 locationNCT07460232
Recruiting
Early Phase 1
Safety and Efficacy Study of PUMCH-E111 Injection in Subjects With RLBP1 Related Inherited Retinal Dystrophy
Inherited Retinal DystrophyInherited Retinal Disease
Peking Union Medical College Hospital6 enrolled1 locationNCT07656753
Recruiting
Early Phase 1
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CTX001 in Healthy Adults.
Chronic Kidney DiseaseIron DeficienciesAnemia
Cajal Therapeutics Inc.72 enrolled1 locationNCT07577817
Recruiting
Early Phase 1
Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia
DementiaAlzheimer DiseaseProgressive Aphasia+3 more
University of Texas at Austin120 enrolled1 locationNCT06511752
Recruiting
Early Phase 1
Evaluation of [¹⁸F]MODAG-009 PET Imaging in Synucleinopathies
Parkinson DiseaseHealthy AdultMultiple System Atrophy (MSA)
MODAG GmbH13 enrolled1 locationNCT07640555
Recruiting
Early Phase 1
Longitudinal TSPO PET Imaging With [18F]DPA-714 in PPMI (PPMI DPA-714 PET Imaging)
Parkinson Disease
University of Alabama at Birmingham60 enrolled1 locationNCT06289582
Recruiting
Early Phase 1
Brain Mechanisms Supporting Cannabis-induced Pain Relief
Chronic Low Back Pain (CLBP)SciaticaLumbar Radiculopathy+4 more
University of California, San Diego100 enrolled1 locationNCT04982965
Recruiting
Early Phase 1
Human Umbilical Cord Mesenchymal Stem Cell-derived Small Extracellular Vesicles for the Treatment of Dry Eye Disease
Umbilical Cord Mesenchymal Stem Cell-derived Small Extracellular VesiclesDry-Eye Disease
The First Affiliated Hospital of Xiamen University20 enrolled1 locationNCT07623382
Recruiting
Early Phase 1
A Clinical Study to Evaluate the Safety and Efficacy of GT801 Injection in the Treatment of Moderate to Severe Refractory Autoimmune Diseases
Moderate to Severe Refractory Autoimmune Diseases
Vivacta Biotechnology (Shanghai) Co., Ltd.22 enrolled1 locationNCT07614191
Recruiting
Early Phase 1
A Clinical Study to Evaluate the Safety and Efficacy of GT801 Injection in the Treatment of Moderate-to-Severe Refractory Autoimmune Diseases
Moderate to Severe Refractory Autoimmune Disease
Grit Biotechnology22 enrolled1 locationNCT07333118
Recruiting
Early Phase 1
Development of a Preparation for Supportive Supplementation of Probiotics in Patients With Reflux
MicrobiomeReflux DiseaseProbiotics Supplement
University Hospital Olomouc50 enrolled1 locationNCT07600008
Recruiting
Early Phase 1
CD19/BCMA UCAR-T for B Cell-Related Autoimmune Disease
IgA Nephropathy (IgAN)Autoimmune DiseasesSystemic Sclerosis (SSc)+3 more
The Children's Hospital of Zhejiang University School of Medicine15 enrolled1 locationNCT07586267
Recruiting
Early Phase 1
Multiple Objective Particle Swarm Optimization Postural Instability Gait Disorder
Parkinson Disease
University of Minnesota60 enrolled1 locationNCT05893186