Early Phase 1 Disease Clinical Trials
103 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 103 trials
Recruiting
Early Phase 1
Multiple Objective Particle Swarm Optimization Postural Instability Gait Disorder
Parkinson Disease
University of Minnesota60 enrolled1 locationNCT05893186
Recruiting
Early Phase 1
Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease
Alzheimer DiseaseMild Cognitive ImpairmentLogopenic Progressive Aphasia+1 more
Massachusetts General Hospital30 enrolled1 locationNCT06538311
Recruiting
Early Phase 1
Real-Time Atherosclerosis Activity After Thoracic Radiotherapy Using Sodium Fluoride Positron Emission Tomography
Oligometastatic Disease
Katelyn Atkins10 enrolled1 locationNCT06373497
Recruiting
Early Phase 1
A Clinical Study of SPH7854 Granules in Healthy Subjects.
Inflammatory Bowel Disease
Shanghai Pharmaceuticals Holding Co., Ltd111 enrolled1 locationNCT06483373
Recruiting
Early Phase 1
Addition of Cord Blood Tissue-Derived Mesenchymal Stromal Cells to Ruxolitinib for the Treatment of Steroid-Refractory Acute Graft Versus Host Disease
Steroid refractory Graft Versus Host DiseaseHematopoietic and Lymphoid Cell Neoplasm
M.D. Anderson Cancer Center24 enrolled1 locationNCT04744116
Recruiting
Early Phase 1
Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease
HypopituitarismArginine vasopressin deficiencyOxytocin Deficiency+1 more
Massachusetts General Hospital20 enrolled1 locationNCT07568509
Recruiting
Early Phase 1
Repurposing Dupilumab for Management of Pruritic Genetic Inflammatory Skin Disorders
Skin Diseases
Northwestern University30 enrolled1 locationNCT05649098
Recruiting
Early Phase 1
Concomitant Renal and Urinary Bladder Allograft Transplantation
Chronic Kidney DiseasesBladder DysfunctionNeurogenic Bladder+6 more
Mayo Clinic30 enrolled2 locationsNCT04626167
Recruiting
Early Phase 1
Merck IIT: RRP Pembro and Lenvatinib
Pulmonary DiseaseRecurrent Respiratory PapillomatosisHuman Papilloma Virus
Yale University20 enrolled1 locationNCT04645602
Recruiting
Early Phase 1
GT719 Injection for Moderate to Severe Refractory Autoimmune Disease
Auto Immune Disease
Grit Biotechnology30 enrolled1 locationNCT07132112
Recruiting
Early Phase 1
Randomized Directly Observed Therapy Study to Interpret Clinical Trials of Doxy-PEP
Sexually Transmitted Diseases, Bacterial
University of California, San Francisco48 enrolled1 locationNCT06414408
Recruiting
Early Phase 1
Allogeneic CD19/BCMA CAR-T for B Cell-Related Autoimmune Disease
IgA Nephropathy (IgAN)Autoimmune DiseasesSystemic Sclerosis (SSc)+3 more
The Children's Hospital of Zhejiang University School of Medicine15 enrolled1 locationNCT07507201
Recruiting
Early Phase 1
A Study of mRNA Encoding CD19/CD3 T Cell Engager (ABO2203) in Patients With Refractory Autoimmune Diseases
Autoimmune Diseases
Ruijin Hospital66 enrolled3 locationsNCT06747156
Recruiting
Early Phase 1
Treatment of Chronic Obstructive Pulmonary Disease (COPD) by REGEND007 Cell Therapy
Chronic Obstructive Pulmonary Disease (COPD)
Regend Therapeutics12 enrolled1 locationNCT07355868
Recruiting
Early Phase 1
In Vivo CAR-T for Refractory Graves' Disease
Graves Disease
Shanghai Zhongshan Hospital5 enrolled1 locationNCT07333677
Recruiting
Early Phase 1
Ceftriaxone Pulse Dose for Post-Treatment Lyme Disease
Post-Treatment Lyme Disease
State University of New York - Upstate Medical University44 enrolled1 locationNCT06611111
Recruiting
Early Phase 1
Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA CAR-NK Cell Injection for the Treatment of Refractory Pediatric Rheumatic Diseases
Systemic Lupus Erythematosus (SLE)Rheumatic DiseasesPediatric Rheumatological Condition (i.e., Arthritis, SLE, Kawasaki's Disaese)+1 more
The Children's Hospital of Zhejiang University School of Medicine36 enrolled1 locationNCT07490041
Recruiting
Early Phase 1
Antimicrobial Effect of Tropolone Containing Versus Tropolone Free Mouthwash
Dental Diseases
Cairo University30 enrolled1 locationNCT03384537
Recruiting
Early Phase 1
Mechanistic Clinical Trial of Colchicine in Patients With Peripheral Artery Disease
Peripheral Artery Disease
University of Pennsylvania24 enrolled1 locationNCT06212271
Recruiting
Early Phase 1
Hydroxychloroquine in Children's Interstitial Lung Diseases With Genetic Causes
Interstitial Lung DiseaseSurfactant Dysfunction
Children's Hospital of Fudan University60 enrolled1 locationNCT04532346