Phase 1 Disorder Clinical Trials
236 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 236 trials
Recruiting
Phase 1
Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)
Alcohol Use Disorder (AUD)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)176 enrolled1 locationNCT07559500
Recruiting
Phase 1
Environment and Alcohol: A Pilot Study
Alcohol Use Disorder
National Institute on Drug Abuse (NIDA)44 enrolled1 locationNCT06860607
Recruiting
Phase 1
A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias
HypercholesterolaemiaMetabolic DiseaseDyslipidemias+7 more
CRISPR Therapeutics AG90 enrolled19 locationsNCT07491172
Recruiting
Phase 1
Psilocybin Whole Mushroom for the Treatment of Obsessive-compulsive Disorder.
Obsessive-Compulsive Disorder
Francisco A Moreno30 enrolled1 locationNCT07347405
Recruiting
Phase 1
Spironolactone in Alcohol Use Disorder (SAUD)
Alcohol Use Disorder
National Institute on Drug Abuse (NIDA)20 enrolled1 locationNCT05807139
Recruiting
Phase 1
Imatinib to Increase RUNX1 Activity in Participants With Germline RUNX1 Deficiency
Inherited Bone Marrow Failure SyndromeFamilial Platelet Disorder With Predisposition to Myeloid Malignancies
National Cancer Institute (NCI)75 enrolled1 locationNCT06090669
Recruiting
Phase 1Phase 2
Study to Assess Safety of HDP-101 in Patients With Relapsed Refractory Multiple Myeloma
Multiple MyelomaPlasma Cell Disorder
Heidelberg Pharma AG78 enrolled24 locationsNCT04879043
Recruiting
Phase 1
A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders
B-cell Mediated Autoimmune Disorders
TG Therapeutics, Inc.100 enrolled8 locationsNCT06680037
Recruiting
Phase 1
Genetic Basis of the Risk and Consequences of Cannabis Exposure in Humans
SchizophreniaCannabis Use Disorder
Yale University215 enrolled1 locationNCT06058702
Recruiting
Phase 1Phase 2
Prospective Clinical Study on Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Childhood Autism
Autism Spectrum Disorder (ASD)Prospective Study
Dongfang People's Hospital60 enrolled1 locationNCT07243561
Recruiting
Phase 1
A Multiple Baseline Feasibility Trial of Social Management Training for People With Sex Chromosome Aneuploidies
Sex Chromosome Disorders
University of Oslo30 enrolled1 locationNCT07718997
Recruiting
Phase 1Phase 2
Intestinal Microbiota Transplant in Alcohol-Associated Liver Disease
CirrhosisAlcohol Use DisorderLiver Disease; Alcohol-Related
Virginia Commonwealth University80 enrolled2 locationsNCT05548452
Recruiting
Phase 1
Pattern Separation in Major Depressive Disorder
Major Depressive Disorder (MDD)
Jeffrey Miller30 enrolled1 locationNCT07139834
Recruiting
Phase 1Phase 2
A PET/MRI Study of Cobenfy on Dopamine Transmission in Schizophrenia
SCHIZOPHRENIA 1 (Disorder)Schizoaffecitve Disorder
New York State Psychiatric Institute12 enrolled1 locationNCT07423546
Recruiting
Phase 1
Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease
Long COVIDSARS CoV-2Neurodegeneration+1 more
Stephanie B. Seminara, MD40 enrolled1 locationNCT07224490
Recruiting
Phase 1Phase 2
Development of Virtual Reality-based Interventions to Strengthen Cognitive Skillsets Related to Attention Deficit Hyperactivity Disorder (ADHD): A Pilot Phase I and Randomized Controlled Phase II Trial
Attention Deficit Hyperactivity Disorder
National Institute of Mental Health (NIMH)219 enrolled1 locationNCT05608434
Recruiting
Phase 1
Investigating the Mechanisms of the Effects of Psilocybin on Visual Perception and Visual Representations in the Brain
Perception Disorders
University of California, Berkeley80 enrolled1 locationNCT05265546
Recruiting
Phase 1Phase 2
Cannabidiol Oil for Treatment-Resistant Major Depression
Major Depressive Disorder (MDD)Treatment Resistant Depression (TRD)
Universidade do Sul de Santa Catarina120 enrolled1 locationNCT07696871
Recruiting
Phase 1
A Study to Evaluate a Novel Gene Therapy in Patients With Relapsed and Refractory Multiple Myeloma
NeoplasmLymphoproliferative DisordersNeoplasms by Histologic Type+11 more
Kelonia Therapeutics, Inc.70 enrolled10 locationsNCT07075185
Recruiting
Phase 1Phase 2
Acetazolamide for Treatment Resistant Schizophrenia
SchizophreniaSchizo Affective Disorder
Vishwajit Nimgaonkar, MD PhD60 enrolled2 locationsNCT04887792