Phase 1 Encephalopathy Clinical Trials
8 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–8 of 8 trials
Recruiting
Phase 1
Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy
Multiple SclerosisProgressive Multifocal Leukoencephalopathy
National Institute of Neurological Disorders and Stroke (NINDS)15 enrolled1 locationNCT05849467
Recruiting
Phase 1Phase 2
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy
Epileptic Encephalopathy
Institut de Recherches Internationales Servier20 enrolled16 locationsNCT07227857
Recruiting
Phase 1Phase 2
Retina is a Marker for Cerebrovascular Heath
Cerebral Small Vessel DiseasesCerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and LeukoencephalopathyCerebral Microbleeding+1 more
Mayo Clinic100 enrolled1 locationNCT04753970
Recruiting
Phase 1
Role of Citicoline in Treatment of Neonates With Hypoxic Ischemic Encephalopathy
Hypoxic Ischemic Encephalopathy of Newborn
Armed Forces Hospital, Pakistan200 enrolled1 locationNCT06522581
Recruiting
Phase 1
Fecal Microbiota Transplantation by Oral Capsules for Hepatic Encephalopathy Treatment
DysbiosisHepatic Encephalopathy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS60 enrolled1 locationNCT06368895
Completed
Phase 1
A Phase 1, First-in-human, Randomized, Double-blind, Placebo-controlled, Single and Multiple Ascending Intravenous Dose Study to Assess the Safety, Tolerability, Pharmacokinetics of VGL101 in Healthy Adults
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia
Vigil Neuroscience, Inc30 enrolled1 locationACTRN12622000933752
Recruiting
Phase 1
ALaCART-B: Acute Leukemia and Chimeric Antigen Receptor-T Cell Therapy for B-lymphoblastic Leukemia.
CARLymphoblastic Leukemia in ChildrenLymphoblastic Leukemia+3 more
National University Hospital, Singapore40 enrolled1 locationNCT05038696
Recruiting
Phase 1
CARTALL: Chimeric-Antigen Receptor (CAR) T-Cell Therapy for Relapsed/ Refractory T-Lineage Acute Lymphoblastic Leukaemia
CARRefractory LeukemiaLymphoblastic Leukemia in Children+4 more
National University Hospital, Singapore20 enrolled1 locationNCT05043571