Phase 1 Encephalopathy Clinical Trials
10 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–10 of 10 trials
Recruiting
Phase 1
Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy
Multiple SclerosisProgressive Multifocal LeukoencephalopathyOther Neuroinflammatory Diseases With BBB Leakage
National Institute of Neurological Disorders and Stroke (NINDS)15 enrolled1 locationNCT05849467
Recruiting
Phase 1Phase 2
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy
Epileptic Encephalopathy
Institut de Recherches Internationales Servier20 enrolled16 locationsNCT07227857
Recruiting
Phase 1
Dose Optimization of Caffeine for HIE
Hypoxic-ischemic encephalopathy.
University of North Carolina, Chapel Hill16 enrolled2 locationsNCT06448780
Recruiting
Phase 1Phase 2
Retina is a Marker for Cerebrovascular Heath
Cerebral Small Vessel DiseasesCerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and LeukoencephalopathyCerebral Microbleeding+1 more
Mayo Clinic100 enrolled1 locationNCT04753970
Recruiting
Phase 1
Role of Citicoline in Treatment of Neonates With Hypoxic Ischemic Encephalopathy
Hypoxic Ischemic Encephalopathy of Newborn
Armed Forces Hospital, Pakistan200 enrolled1 locationNCT06522581
Recruiting
Phase 1Phase 2
Neonatal Hypoxic Ischemic Encephalopathy : Safety and Feasibility Study of a Curative Treatment With Autologous Cord Blood Stem Cells
neonatal hypoxic ischaemic encephalopathy
Assistance Publique Hopitaux De Marseille20 enrolled1 locationNCT02881970
Recruiting
Phase 1
Fecal Microbiota Transplantation by Oral Capsules for Hepatic Encephalopathy Treatment
DysbiosisHepatic Encephalopathy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS60 enrolled1 locationNCT06368895
Completed
Phase 1
A Phase 1, First-in-human, Randomized, Double-blind, Placebo-controlled, Single and Multiple Ascending Intravenous Dose Study to Assess the Safety, Tolerability, Pharmacokinetics of VGL101 in Healthy Adults
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia
Vigil Neuroscience, Inc30 enrolled1 locationACTRN12622000933752
Recruiting
Phase 1
CARTALL: Chimeric-Antigen Receptor (CAR) T-Cell Therapy for Relapsed/ Refractory T-Lineage Acute Lymphoblastic Leukaemia
CARRefractory LeukemiaLymphoblastic Leukemia in Children+4 more
National University Hospital, Singapore20 enrolled1 locationNCT05043571
Recruiting
Phase 1
ALaCART-B: Acute Leukemia and Chimeric Antigen Receptor-T Cell Therapy for B-lymphoblastic Leukemia.
CARLymphoblastic Leukemia in ChildrenLymphoblastic Leukemia+3 more
National University Hospital, Singapore40 enrolled1 locationNCT05038696