ESRD Clinical Trials

34 recruitingLast updated: June 18, 2026

There are 34 actively recruiting esrd clinical trials across 17 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4. Top locations include Orangeburg, South Carolina, United States, Boston, Massachusetts, United States, Charlotte, North Carolina, United States. Updated daily from ClinicalTrials.gov.


ESRD Trials at a Glance

34 actively recruiting trials for esrd are listed on ClinicalTrialsFinder across 6 cities in 17 countries. The largest study group is Not Applicable with 14 trials, with the heaviest enrollment activity in Orangeburg, Boston, and Charlotte. Lead sponsors running esrd studies include McGill University Health Centre/Research Institute of the McGill University Health Centre, Stanford University, and United Therapeutics.

Browse esrd trials by phase

Treatments under study

About ESRD Clinical Trials

Looking for clinical trials for ESRD? There are currently 7 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new ESRD trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about ESRD clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 34 trials

Recruiting
Not Applicable

Pivotal Study of the Velocity™ pAVF System

Chronic Kidney DiseaseEnd Stage Renal Disease (ESRD)Hemodialysis Access+1 more
Venova Medical126 enrolled12 locationsNCT07153939
Recruiting
Not Applicable

Preoperative Hemodialysis Timing in Patients With End-Stage Kidney Disease: The POD-ESKD Pilot Trial

End Stage Kidney Disease (ESRD)HemodialysisPerioperative Management
Stanford University30 enrolled1 locationNCT07339202
Recruiting
Phase 1Phase 2

Study to Evaluate the Safety and Efficacy of the GGTA1 KO Thymokidney in Patients With ESRD

Kidney TransplantationXenotransplantationESRD (End-Stage Renal Disease)
United Therapeutics50 enrolled1 locationNCT07224763
Recruiting
Not Applicable

RaDIANT Health Systems Intervention

Kidney DiseaseEnd Stage Renal Disease (ESRD)
Indiana University14,000 enrolled5 locationsNCT07033117
Recruiting
Not Applicable

Effect of the Amplifi™ Vein Dilation System on Outflow Vein Dilation and AV Fistula Maturation (AMPLIFI-1)

End Stage Kidney Disease (ESRD)
Amplifi Vascular, Inc.160 enrolled1 locationNCT07211035
Recruiting
Not Applicable

STARgraft (10401) Pilot

End Stage Kidney Disease (ESRD)
Healionics Corporation20 enrolled1 locationNCT07555717
Recruiting

Calciphylaxis in Patients With Chronic Kidney Disease - A Study of the Danish Calciphylaxis Research Initiative (DanCaRI)

Chronic Kidney DiseasesEnd Stage Renal Disease (ESRD)Calciphylaxis+2 more
Odense University Hospital860 enrolled1 locationNCT07511283
Recruiting
Not Applicable

Repletion of Ergothioneine in Patients With Kidney Failure

ESRD
Stanford University28 enrolled1 locationNCT06487546
Recruiting
Phase 1Phase 2

Study to Evaluate the Safety and Efficacy of the 10 GE Xenokidney in Patients With ESRD

Kidney TransplantationXenotransplantationESRD (End-Stage Renal Disease)
United Therapeutics50 enrolled2 locationsNCT06878560
Recruiting

Sensor-based Congestion ALert for Events in Peritoneal Dialysis (SCALE-PD)

Kidney DiseaseEnd Stage Kidney Disease (ESRD)Peritoneal Dialysis (PD)
Bodyport Inc.125 enrolled4 locationsNCT07059962
Recruiting
Not Applicable

Effect of a Plant-Focused Diet on Nutritional Status in Malnourished Peritoneal Dialysis Patients

End Stage Kidney Disease (ESRD)End Stage Renal Disease (ESRD)Peritoneal Dialysis (PD)+1 more
National University of Malaysia100 enrolled1 locationNCT07157397
Recruiting
Phase 2

Effect of Canagliflozin on Ultrafiltration & Fibrosis in Patients on Peritoneal Dialysis

CKD (Chronic Kidney Disease) Stage 5DESRD
McGill University Health Centre/Research Institute of the McGill University Health Centre30 enrolled1 locationNCT06913647
Recruiting
Not Applicable

SAVE-FistulaS: the SelfWrap-Assisted ArterioVEnous Fistulas Study

Chronic Kidney DiseasesArteriovenous FistulaVascular Access Complication+7 more
VenoStent600 enrolled28 locationsNCT06001827
Recruiting
Phase 1Phase 2

Adding Urea to the Final Dialysis Fluid

HyperkalemiaMetabolic AcidosisDysequilibrium Syndrome+1 more
University of California, San Francisco20 enrolled1 locationNCT06366230
Recruiting
Phase 3

A Study of a Novel Iron-based Phosphate Binder AP301 in Patients With Hyperphosphatemia in the U.S. and China

HyperphosphatemiaDialysisChronic Kidney Disease, Receiving Dialysis+1 more
Alebund Pharmaceuticals264 enrolled42 locationsNCT06933472
Recruiting

EndoForce Post Approval Study

End Stage Renal Disease (ESRD)
Phraxis, Inc.150 enrolled2 locationsNCT07146854
Recruiting
Not Applicable

A Comparative Study of Intradialytic vs. Pre-Dialysis Physical Therapy Interventions in Individuals Undergoing Hemodialysis: A Randomized Controlled Trial

Chronic Kidney DiseaseEnd Stage Renal Disease (ESRD)Hemodialysis Patients+1 more
Mohammad Arian72 enrolled1 locationNCT07361146
Recruiting
Not Applicable

Expanded Hemodialysis Versus High-Volume Online Hemodiafiltration for Uremic Toxin Removal

HemodialysisEnd Stage Renal Disease (ESRD)Chronic Kidney Disease on Hemodialysis+3 more
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran15 enrolled1 locationNCT07348536
Recruiting
Not Applicable

A Study to Evaluate the Safety and Effectiveness of the InnAVasc Arteriovenous Graft for Hemodialysis Access in Patients With End-Stage Renal Disease

HemodialysisEnd Stage Renal Disease (ESRD)Kidney Failure+1 more
W.L.Gore & Associates133 enrolled21 locationsNCT04671771
Recruiting
Not Applicable

Impact of APP-assisted Patient Management on the Quality Control of Blood Purification Therapy

End Stage Renal Disease (ESRD)Maintenance Hemodialysis
Yunfeng Xia392 enrolled1 locationNCT07291154