Estrogen Clinical Trials

1 recruiting

Frequently Asked Questions

Common questions about Estrogen clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 119 of 19 trials

Recruiting
Phase 2

Turkey Tail Mushroom for Treating Post-Menopausal Women With HER2-Negative ER-Positive Breast Cancer Undergoing Surgery

Estrogen Receptor-Positive Breast CarcinomaHER2-Negative Breast Carcinoma
Mayo Clinic40 enrolled1 locationNCT06450873
Recruiting
Phase 3

A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer
Hoffmann-La Roche1,050 enrolled351 locationsNCT06065748
Recruiting
Not Applicable

Multicenter Trial for Eliminating Breast Cancer Surgery or Radiotherapy in Exceptional Responders to Neoadjuvant Systemic Therapy

Estrogen Receptor Negative
M.D. Anderson Cancer Center120 enrolled8 locationsNCT02945579
Recruiting

Enhancing Skin Appearance and Quality of Life in Breast Cancer Survivors on Aromatase Inhibitor Therapy

Estrogen Receptor-Positive Breast CarcinomaAnatomic Stage II Breast Cancer AJCC v8Anatomic Stage III Breast Cancer AJCC v8+4 more
Mayo Clinic25 enrolled1 locationNCT06401889
Recruiting
Phase 2

Reishi Mushroom Extract for Fatigue and/or Arthralgias/Myalgias in Patients With Breast Cancer on Aromatase Inhibitors

Estrogen Receptor-Positive Breast Carcinoma
Mayo Clinic80 enrolled23 locationsNCT06028022
Recruiting
Phase 3

Estradiol and Testosterone Subdermal Implants for Menopause Treatment (ESTIME)

MenopauseTestosterone DeficiencyEstrogen Deficiency
University of Sao Paulo General Hospital140 enrolled1 locationNCT06343870
Recruiting

Active Surveillance in Older Women With ER+ Breast Cancer

Early Stage Estrogen Receptor (ER) Positive Breast Cancer
University of Pittsburgh50 enrolled1 locationNCT07262138
Recruiting
Phase 2

Stereotactic Body Radiation Therapy and FES PET/CT Imaging for the Treatment of Oligoprogressive Estrogen Receptor Positive Metastatic Breast Cancer

Estrogen Receptor-Positive Breast CarcinomaAnatomic Stage IV Breast Cancer AJCC v8Metastatic Breast Carcinoma
City of Hope Medical Center18 enrolled2 locationsNCT06260033
Recruiting
Phase 2

The SAPPHO Study: Sequential Therapy With Curative Intent in de Novo HER2+ Metastatic Breast Cancer

Breast CancerBreast Cancer MetastaticBreast Cancer Female+3 more
Dana-Farber Cancer Institute72 enrolled1 locationNCT06439693
Recruiting
Phase 4

OFS in Premenopausal Node+ Breast Cancer With Low Genomic Risk

Breast CancerNode-positive Breast CancerHER2-negative Breast Cancer+2 more
Gangnam Severance Hospital418 enrolled2 locationsNCT05333328
Recruiting
Not Applicable

S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

Anatomic Stage IV Breast Cancer AJCC v8Prognostic Stage IV Breast Cancer AJCC v8HER2/Neu Negative+3 more
SWOG Cancer Research Network739 enrolled723 locationsNCT03723928
Recruiting
Not Applicable

Enabling Women with Parkinson's Disease to Identify and Better Manage Hormonal Triggers of Parkinsonian Symptoms

Parkinson DiseaseDigital TechnologyMobile Application+2 more
University Hospital, Grenoble100 enrolled4 locationsNCT06582212
Recruiting

InvEstigating oeStrogen Signalling and the Effect upoN the exTracelluar Matrix In pAtients With Obstructive Lung Disease

AsthmaRespiratory IlnessEstrogen Deficiency+1 more
Guy's and St Thomas' NHS Foundation Trust100 enrolled1 locationNCT06713512
Recruiting

ENDO-BRAIN: Effects of Endocrine Adjuvant Therapy with Aromatase Inhibitors on the Cognitive Function of Breast Cancer Patients

Cognitive Side Effects of Cancer TherapyHypoestrogenism
Ospedale Policlinico San Martino60 enrolled1 locationNCT06606535
Recruiting

Characterization of Biophysical and Mechanical Parameters on Skin of Breast Cancer Patients

Breast CancerEstrogen Receptor Positive Tumor
European Institute of Oncology150 enrolled1 locationNCT06474988
Recruiting
Not Applicable

Assessment of the Improvement in Cognitive Levels of Postmenopausal Depression Patients by Estrogen

Postmenopausal DepressionEstrogen
Xiao Wang40 enrolled1 locationNCT06358014
Recruiting

Estrogen Receptor (ER) PET/CT Imaging in Breast Cancer

Breast CancerTNBC - Triple-Negative Breast CancerEstrogen-receptor-negative Breast Cancer
Tongji Hospital80 enrolled1 locationNCT05541367
Recruiting
Phase 2

Pembrolizumab and Carboplatin in Treating Patients With Circulating Tumor Cells Positive Metastatic Breast Cancer

Triple-Negative Breast CarcinomaRecurrent Breast CarcinomaStage IV Breast Cancer+4 more
Northwestern University100 enrolled1 locationNCT03213041
Recruiting
Phase 3

The MASTER Study (MAmmary Cancer STatin ER Positive Study)

Breast Cancer FemaleEstrogen Receptor Positive Tumor
Aarhus University Hospital3,360 enrolled1 locationNCT04601116