Phase 4 Fibrosis Clinical Trials
23 recruitingPhase 4
What is a Phase 4 trial?
Phase 4 trials, also called post-marketing studies, are conducted after a treatment has been approved and is available to the public. They monitor long-term effectiveness and safety in a broader population.
Showing 1–20 of 23 trials
Recruiting
Phase 4
High Relaxivity Contrast Agent for Cardiac MR in the Myocardial Scar Assessment
Myocardial Fibrosis
Johns Hopkins University25 enrolled2 locationsNCT05954559
Recruiting
Phase 4
Estrogen Supplementation and Bone Health in Women With CF
HypoestrogenismCystic Fibrosis
Johns Hopkins University75 enrolled1 locationNCT05704036
Recruiting
Phase 4
Ensuring Access to Optimal Therapy in CF: The ENACT Study
Cystic Fibrosis (CF)
Arkansas Children's Hospital Research Institute95 enrolled2 locationsNCT07148739
Recruiting
Phase 4
Hypertonic Saline in NCFB
BronchiectasisNon-cystic Fibrosis Bronchiectasis
University of North Carolina, Chapel Hill20 enrolled1 locationNCT06242795
Recruiting
Phase 4
Early Discontinuation of Steroid Treatment in Negative FDG-PET/CT Patients With Idiopathic Retroperitoneal Fibrosis
Idiopathic Retroperitoneal Fibrosis
Assistance Publique - Hôpitaux de Paris41 enrolled15 locationsNCT05428826
Recruiting
Phase 4
Markers of Osteoporosis in Cystic Fibrosis
Cystic Fibrosis
University of Texas Southwestern Medical Center100 enrolled1 locationNCT03921060
Recruiting
Phase 4
Effect of Erugliflozin On Liver Fat, Liver Fibrosis and Glycemic Control in Type II DM Patients With NASH/NAFLD
Liver FibrosisGlycemic ControlLiver Fat+3 more
Getz Pharma164 enrolled1 locationNCT05644717
Recruiting
Phase 4
BEGIN Novel ImagiNG Biomarkers
Cystic Fibrosis
Children's Hospital Medical Center, Cincinnati44 enrolled3 locationsNCT05517655
Recruiting
Phase 4
Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study
Cystic FibrosisCystic Fibrosis Pulmonary Exacerbation
Chris Goss730 enrolled60 locationsNCT05548283
Recruiting
Phase 4
ORganoId GuIded N-of-1 (ORIGIN-1) Trial: A phase 4 study to investigate whether people with cystic fibrosis (CF) with rare cystic fibrosis transmembrane regulator (CFTR) mutations who have an in vitro response to Trikafta will also have a clinically meaningful response to Trikafta versus placebo
Cystic Fibrosis
The University of Newcastle20 enrolled1 locationACTRN12623001136695
Not Yet Recruiting
Phase 4
Ceftolozane/Tazobactam Continuous Intravenous Infusion given in an Outpatient Setting to treat Infective Exacerbations of Cystic Fibrosis and Bronchiectasis
Cystic FibrosisBronchiectasis
Sunshine Coast Hospital and Health Service30 enrolled3 locationsACTRN12623000976684
Not Yet Recruiting
Phase 4
Do methods to reduce gastro esophageal reflux (GER) including sleeping posture (elevation of the head of the bad) and use of protein pump inhibitor medications, also reduce pepsin (normally not found in the lung) in the exhaled breath of people with GER.
Gastro oesophageal reflux (GER)Idiopathic Pulmonary Fibrosis (IPF)
Mater Misericordiae LTD20 enrolled1 locationACTRN12623000430639
Withdrawn
Phase 4
A double blind, randomized, placebo controlled, cross-over trial investigating the effect of High Amylose Maize Starch (HAMS) supplementation on fecal microbiological and inflammatory outcomes in individuals with Cystic Fibrosis and Healthy Volunteers.
Cystic Fibrosis
Mater Misericordiae Ltd20 enrolled1 locationACTRN12618000283279
Recruiting
Phase 4
The effect of ivacaftor (VX-770, registered in Australia as Kalydeco) on exocrine pancreatic function in patients 6 years and older with cystic fibrosis and at least one copy of the G551D CFTR mutation and who are naive for ivacaftor
Cystic Fibrosis
Sydney Children's Hospitals Network20 enrolled1 locationACTRN12614000356662
Recruiting
Phase 4
Continuous infusion antipseudomonal beta-lactams for acute infective exacerbations in cystic fibrosis: a prospective randomised controlled trial
Acute pulmonary exacerbation of cystic fibrosis
Dr Anton Peleg120 enrolled1 locationACTRN12612000945820
Terminated
Phase 4
CHiRRP: Combating Haemophilus influenzae Related Respiratory Pathology
Suppurative lung disease (excluding cystic fibrosis)
University of Queensland206 enrolled1 locationACTRN12612000034831
Recruiting
Phase 4
A Randomised trial of the effect of timing of nebulised hypertonic saline in relation to airway clearance physiotherapy, in people with Cystic Fibrosis lung disease.
Cystic Fibrosis
Royal Prince Alfred Hospital, SSWAHS50 enrolled1 locationACTRN12611000673943
Recruiting
Phase 4
A randomised cross over pilot study of inhaled tobramycin as a treatment option for hospitalised patients with cystic fibrosis versus standard treatment of intravenous tobramycin
Cystic Fibrosis
Royal Adelaide Hospital24 enrolled1 locationACTRN12609000016235
Completed
Phase 3Phase 4
The long term effect of inhaled hypertonic saline (6%) in non-cystic fibrosis bronchiectasis.
Non-cystic fibrosis bronchiechtasis
Alfred Hospital, Physiotherapy Department40 enrolled1 locationACTRN12607000367448
Recruiting
Phase 4
IMPROVING SELF-MANAGEMENT IN ADOLESCENTS AND ADULTS WITH CYSTIC FIBROSIS.
Cystic FibrosisAdolescence and the transition period
Australian Cystic Fibrosis Research Trust60 enrolledACTRN12607000234415