Phase 1 Fibrosis Clinical Trials
86 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 86 trials
Recruiting
Phase 1
Study of Pelabresib add-on to Ruxolitinib in Japanese Adult Patients With Myelofibrosis
Primary myelofibrosis (PMF)Post-polycythemia Vera Myelofibrosis (Post-PV MF)Post-essential Thrombocythemia Myelofibrosis(Post-ET MF)
Novartis Pharmaceuticals6 enrolled7 locationsNCT07340138
Recruiting
Phase 1
A Phase 1 Study of PRT12396 in Participants With Select Myeloproliferative Neoplasms
Primary myelofibrosis (PMF)Post-polycythemia Vera MyelofibrosisPost-essential Thrombocythemia Myelofibrosis+3 more
Prelude Therapeutics100 enrolled5 locationsNCT07469891
Recruiting
Phase 1Phase 2
Scar Remodeling After Burn Injury Using Allogeneic Adipose-derived Stromal Cells
Scar Conditions and Fibrosis of SkinScar Quality Assessment and SafetyScar Tissue
Rigshospitalet, Denmark39 enrolled1 locationNCT07635875
Recruiting
Phase 1
AlloHCT With PegINFa for Myelofibrosis
Myelofibrosis
University of Utah18 enrolled1 locationNCT05535764
Recruiting
Phase 1
A Study to Test the Safety and Effects of Inhaled GDC-6988 in Participants With Muco-obstructive Disease
Chronic Obstructive Pulmonary DiseaseNon-cystic Fibrosis Bronchiectasis
Genentech, Inc.128 enrolled7 locationsNCT06603246
Recruiting
Phase 1
A Study of Rebecsinib for Patients With Relapsed/Refractory Secondary Acute Myeloid Leukemia or High Risk Myelofibrosis
MyelofibrosisSecondary AML
Aspera Biomedicines, Inc.28 enrolled1 locationNCT07250646
Recruiting
Phase 1
Molecular Imaging Probes to Inform Heterogeneity in Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis
University of Alabama at Birmingham10 enrolled1 locationNCT04362644
Recruiting
Phase 1Phase 2
Open Label Phase 1/2 Study of Tasquinimod in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (Post-PV MF), or Post-Essential Thrombocytosis Myelofibrosis (Post-ET MF)
Primary MyelofibrosisPost-polycythemia Vera MyelofibrosisPost-Essential Thrombocytosis Myelofibrosis
M.D. Anderson Cancer Center33 enrolled1 locationNCT06327100
Recruiting
Phase 1
Therapeutic RSK1 Targeting in Myelofibrosis
Myelofibrosis
Washington University School of Medicine18 enrolled1 locationNCT07379125
Recruiting
Phase 1
A Study to Evaluate Pharmacokinetics and Drug-drug Interactions of ENV-101 (Taladegib) in Healthy Participants
Idiopathic Pulmonary Fibrosis
Endeavor Biomedicines, Inc.57 enrolled2 locationsNCT07454291
Recruiting
Phase 1
Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-581 in Healthy Participants
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated128 enrolled1 locationNCT07283770
Recruiting
Phase 1Phase 2
Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia
Myelodysplastic SyndromesMyelofibrosisAnemia+4 more
Disc Medicine, Inc150 enrolled25 locationsNCT05320198
Recruiting
Phase 1
A Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I JAK2 Inhibitor (JAK2i)
Primary MyelofibrosisPost-polycythemia Vera MyelofibrosisPost-essential Thrombocythemia Myelofibrosis+3 more
Ajax Therapeutics, Inc.76 enrolled21 locationsNCT06343805
Recruiting
Phase 1
Clinical Study of CFH Protein Via Ice Microneedles for Radiation-Induced Skin Fibrosis
Head and Neck Squamous Cell CarcinomaRadiation-Induced Skin Fibrosis
West China Hospital9 enrolled1 locationNCT07567235
Recruiting
Phase 1
A Study to Evaluate Safety, Tolerability and Pharmacokinetics of MNKD-201 in Patients With Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis (IPF)
Mannkind Corporation24 enrolled9 locationsNCT07344558
Recruiting
Phase 1
A Study Assessing KB407 for the Treatment of Cystic Fibrosis
Cystic Fibrosis
Krystal Biotech, Inc.20 enrolled6 locationsNCT05504837
Recruiting
Phase 1
Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease
AsthmaCOPDCystic Fibrosis+4 more
Mario Castro, MD, MPH260 enrolled1 locationNCT04624490
Recruiting
Phase 1Phase 2
A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis
Myelofibrosis
Sumitomo Pharma America, Inc.240 enrolled84 locationsNCT04176198
Recruiting
Phase 1
Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.
Acute Myeloid LeukemiaChronic Lymphocytic LeukemiaNon-Hodgkin Lymphoma+10 more
Newave Pharmaceutical Inc100 enrolled8 locationsNCT04771572
Recruiting
Phase 1Phase 2
COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER
Colorectal, CancerStenosisFibrosis, Liver+4 more
Massachusetts General Hospital80 enrolled1 locationNCT05692024