Phase 1 Fibrosis Clinical Trials
77 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 77 trials
Recruiting
Phase 1Phase 2
A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis
Myelofibrosis
Sumitomo Pharma America, Inc.240 enrolled84 locationsNCT04176198
Recruiting
Phase 1Phase 2
Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia
Myelodysplastic SyndromesMyelofibrosisAnemia+4 more
Disc Medicine, Inc150 enrolled24 locationsNCT05320198
Recruiting
Phase 1
A Phase 1 Study of PRT12396 in Participants With Select Myeloproliferative Neoplasms
Myelofibrosis (MF)Polycythemia Vera (PV)Myeloproliferative Neoplasms (MPNs)
Prelude Therapeutics100 enrolled1 locationNCT07469891
Recruiting
Phase 1
The Phase 1, Open-label, PET Trial Designed to Investigate the Effect of AZD2389 on FAP Occupancy in the Liver in Participants With Advanced Liver Fibrosis.
Hepatic CirrhosisLiver Fibrosis
AstraZeneca12 enrolled2 locationsNCT07069725
Recruiting
Phase 1Phase 2
A Study of Roginolisib in Combination With Ruxolitinib in Patients With Myelofibrosis (MF) Who Are Unresponsive to JAK Inhibitors
Myelofibrosis (MF)
iOnctura26 enrolled11 locationsNCT06887803
Recruiting
Phase 1
Study on the Drug Interactions of HRS-9813, Pirfenidone and Nintedanib in Healthy Subjects
Pulmonary Fibrosis
Guangdong Hengrui Pharmaceutical Co., Ltd20 enrolled1 locationNCT07229716
Recruiting
Phase 1
A Study to Evaluate Safety, Tolerability and Pharmacokinetics of MNKD-201 in Patients With Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis (IPF)
Mannkind Corporation24 enrolled8 locationsNCT07344558
Recruiting
Phase 1
Evaluation of VX-828 in Healthy Participants and in Participants With Cystic Fibrosis
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated255 enrolled12 locationsNCT06154447
Recruiting
Phase 1Phase 2
A Study to Test the Safety and Effects of Inhaled GDC-6988 in Participants With Muco-obstructive Disease
Chronic Obstructive Pulmonary DiseaseNon-cystic Fibrosis Bronchiectasis
Genentech, Inc.128 enrolled7 locationsNCT06603246
Recruiting
Phase 1
UAB 2419-CD34 Selection Using the Automated CliniMACS Prodigy
AMLMyelodysplastic SyndromesCML+3 more
University of Alabama at Birmingham50 enrolled1 locationNCT06047886
Recruiting
Phase 1
NAL ER IPF Respiratory Function and Safety Study
Idiopathic Pulmonary Fibrosis
Trevi Therapeutics10 enrolled2 locationsNCT07036029
Recruiting
Phase 1
To Evaluate the Pharmacokinetics and Safety of TQ05105 Tablet in Hepatic Impairment Subjects
Myelofibrosis
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.24 enrolled2 locationsNCT07480824
Recruiting
Phase 1
Dorzagliatin in Pancreatic Insufficient Cystic Fibrosis
Cystic Fibrosis-related DiabetesPancreatic Insufficiency
University of Pennsylvania15 enrolled2 locationsNCT06995651
Recruiting
Phase 1Phase 2
A Study of Ruxolitinib in Combination With Ulixertinib in People With Myelofibrosis
Myelofibrosis
Memorial Sloan Kettering Cancer Center37 enrolled9 locationsNCT06773195
Recruiting
Phase 1
Momelotinib During and After HCT in Myelofibrosis
MyelofibrosisHematopoietic Cell Transplantation (HCT)
Massachusetts General Hospital28 enrolled1 locationNCT07104799
Recruiting
Phase 1
Phase IA and IB Study of AAVrh.10hFXN Gene Therapy for the Cardiomyopathy of Friedreich's Ataxia
CardiomyopathiesFriedreich AtaxiaMyocardial Fibrosis+1 more
Weill Medical College of Cornell University25 enrolled1 locationNCT05302271
Recruiting
Phase 1
Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-272 in Healthy Participants
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated128 enrolled1 locationNCT07437105
Recruiting
Phase 1
A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant
Hematopoietic and Lymphatic System NeoplasmAcute Lymphoblastic LeukemiaAcute Myeloid Leukemia+9 more
City of Hope Medical Center46 enrolled3 locationsNCT07020533
Recruiting
Phase 1
A Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I JAK2 Inhibitor (JAK2i)
Primary Myelofibrosis
Ajax Therapeutics, Inc.76 enrolled16 locationsNCT06343805
Recruiting
Phase 1Phase 2
A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF)
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated39 enrolled43 locationsNCT05668741