Generalized Anxiety Clinical Trials

67 recruitingLast updated: June 18, 2026

There are 67 actively recruiting generalized anxiety clinical trials across 24 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4. Top locations include Boston, Massachusetts, United States, Austin, Texas, United States, Dallas, Texas, United States. Updated daily from ClinicalTrials.gov.


Generalized Anxiety Trials at a Glance

67 actively recruiting trials for generalized anxiety are listed on ClinicalTrialsFinder across 6 cities in 24 countries. The largest study group is Not Applicable with 40 trials, with the heaviest enrollment activity in Boston, Austin, and Dallas. Lead sponsors running generalized anxiety studies include Karolinska Institutet, Beijing Union Pharmaceutical Factory Ltd, and Baylor College of Medicine.

Browse generalized anxiety trials by phase

Treatments under study

About Generalized Anxiety Clinical Trials

Looking for clinical trials for Generalized Anxiety? There are currently 9 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Generalized Anxiety trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Generalized Anxiety clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 67 trials

Recruiting
Phase 2

Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder

Generalized Anxiety Disorder (GAD)
AbbVie315 enrolled52 locationsNCT06846320
Recruiting
Not Applicable

CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy

Post Traumatic Stress DisorderObsessive-Compulsive DisorderSocial Anxiety Disorder+2 more
Jasper A. Smits600 enrolled2 locationsNCT05467683
Recruiting
Not Applicable

Personalized AI-Driven Models in Cognitive Behavioral Therapy for Anxiety

Generalized Anxiety Disorder (GAD)
University of Southern California140 enrolled1 locationNCT07430800
Recruiting
Not Applicable

Neurofeedback Enhanced Cognitive Reappraisal Training - Phase 4

AnxietySocial Anxiety DisorderGeneralized Anxiety Disorder+1 more
University of Michigan110 enrolled1 locationNCT06563310
Recruiting
Not Applicable

Mobile Intervention for Mental Health of Family Caregivers in Thailand

Depressive Symptoms, Generalized Anxiety, or Psychological Stress
Brigham and Women's Hospital400 enrolled1 locationNCT06722287
Recruiting

Validation of the CIDI 5.0 Against the SCID-5 for Lifetime Mental Disorders

Major Depressive Disorder (MDD)Posttraumatic Stress Disorder (PTSD)Generalized Anxiety Disorder (GAD)
The University of Hong Kong300 enrolled1 locationNCT07604753
Recruiting

Triage Survey for Psychiatry Research Eligibility

Major Depressive DisorderGeneralized Anxiety DisorderBorderline Personality Disorder
Adams Clinical20,000 enrolled6 locationsNCT05800925
Recruiting
Phase 2

RE104 Safety and Efficacy Study in Generalized Anxiety Disorder

Generalized Anxiety Disorder
Reunion Neuroscience Inc64 enrolled12 locationsNCT07489651
Recruiting
Not Applicable

Implementing Team-Based Treatment for Pediatric Anxiety in Community Mental Health Settings

AnxietyObsessive Compulsive Disorder (OCD)Social Anxiety Disorder+12 more
Bradley Hospital501 enrolled1 locationNCT06934525
Recruiting
Not Applicable

A Transdiagnostic, Self-guided Internet Intervention ("Velibra") for Waitlist Patients With Anxiety Disorders

Social Anxiety DisorderGeneralized Anxiety DisorderPanic Disorder With Agoraphobia+1 more
Charite University, Berlin, Germany30 enrolled1 locationNCT04793828
Recruiting
Not Applicable

Group vs. Individual Metacognitive Therapy for Generalized Anxiety Disorder

Generalized Anxiety Disorder
Sorlandet Hospital HF64 enrolled2 locationsNCT07579897
Recruiting

An Examination of the Performance of QbMobile in Differential Diagnosis Associated With ADHD Symptoms

Social Anxiety DisorderAutism Spectrum Disorder (ASD)Major Depression Disorders+3 more
Qbtech AB300 enrolled1 locationNCT07329673
Recruiting
Not Applicable

Optimization of Late Imagery Rescripting Research Using Generative Artificial Intelligence

RuminationGeneralized AnxietyFear of Failure
University of Social Sciences and Humanities, Warsaw40 enrolled2 locationsNCT07565714
Recruiting
Not Applicable

Mindful Self-compassion for Anxiety and Depression: Impact of Delivery Method

Major Depressive DisorderAnxiety DisordersSocial Anxiety Disorder+4 more
Georgetown University80 enrolled1 locationNCT07028216
Recruiting
Not Applicable

Text Message Safety Behavior Fading for Pathological Worry

WorryingAnxietyGeneralized Anxiety Disorder (GAD)
Florida State University300 enrolled1 locationNCT07391020
Recruiting
Not Applicable

Targeting Social Function in Anxiety and Eating Disorders

Anorexia NervosaBulimia NervosaEating Disorders+5 more
University of Texas Southwestern Medical Center60 enrolled1 locationNCT06198023
Recruiting
Not Applicable

Enhancing Health in Rural Populations: Music as Therapy

StressChronic PainDepression Disorder+1 more
Northern Arizona University60 enrolled2 locationsNCT07538427
Recruiting

Validation of a Rapid Screening Tool for Anxiety-depressive Disorders in Children, Adolescents and Young Adults Treated in Oncology. Multicenter Study.

Depression, AnxietySurvivors of Childhood CancerGeneralized Anxiety+1 more
Centre Hospitalier Universitaire de Saint Etienne545 enrolled7 locationsNCT07117058
Recruiting
Not Applicable

Transdiagnostic Metacognitive Therapy Compared to Disorder-Specific Cognitive-Behavioral Therapy for Anxiety Disorders

Posttraumatic Stress Disorder (PTSD)Generalized Anxiety Disorder (GAD)Social Anxiety Disorder (SAD)
Karolinska Institutet86 enrolled1 locationNCT06937892
Recruiting
Phase 3

A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Panorama)

Generalized Anxiety Disorder
Definium Therapeutics US, Inc.250 enrolled38 locationsNCT06809595