Phase 2 Head and Neck Cancer Clinical Trials
64 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 64 trials
Recruiting
Phase 2
ATATcH Alternating Treatment Plans for Advanced Cancer
Lung CancerHead and Neck Cancer
Rutgers, The State University of New Jersey150 enrolled11 locationsNCT05358548
Recruiting
Phase 2
Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States Population
Head and Neck CancerOropharynx CancerHypopharynx Cancer+3 more
Mayo Clinic25 enrolled1 locationNCT06997068
Recruiting
Phase 2
Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)
Head and Neck CancerLaryngeal CancerOral Cavity Cancer+6 more
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins75 enrolled1 locationNCT07209189
Recruiting
Phase 2
Invert-Prospective Phase II Randomized Trial of Involved Nodal Versus Elective Neck RadioTherapy
Head and Neck Cancer
University of Texas Southwestern Medical Center80 enrolled1 locationNCT06477692
Recruiting
Phase 2Phase 3
A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1
Unresectable Head and Neck Squamous Cell CarcinomaMetastatic Head and Neck CancerRecurrent Head and Neck Cancer
BioNTech SE350 enrolled193 locationsNCT04534205
Recruiting
Phase 1Phase 2
Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent Head and Neck Squamous Cell Carcinoma
Head and Neck CancerRecurrent Head and Neck Squamous Cell Carcinoma
University of Cincinnati40 enrolled1 locationNCT07213934
Recruiting
Phase 2Phase 3
A Trial Evaluating Omission of Radiotherapy to Regional Lymphatic's
Head and Neck Cancer
All India Institute of Medical Sciences396 enrolled1 locationNCT07528495
Recruiting
Phase 2
A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance and Safety of Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer, in Patients With Unknown Primary Head and Neck Cancer (ILLUMINATE STUDY)
Head and Neck CancerHead and Neck Squamous Cell CarcinomaUnknown Primary Cancer
University of Texas Southwestern Medical Center120 enrolled1 locationNCT05576974
Recruiting
Phase 2
Intraoperative Molecular Imaging Using ICG for Head and Neck Tumors
Margin AssessmentSquamous Cell Carcinoma Head and Neck Cancer (HNSCC)
Medical University of South Carolina30 enrolled1 locationNCT07149207
Recruiting
Phase 2
Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC
Head and Neck CancerSquamous Cell Carcinoma
H. Lee Moffitt Cancer Center and Research Institute35 enrolled1 locationNCT06137274
Recruiting
Phase 2
Efficacy and Safety Evaluation of VS-101 in Combination With Chemoradiotherapy in Patients With Head and Neck Cancer
Head and Neck Cancer Squamous Cell Carcinoma
VSPharmTech Co.,Ltd.30 enrolled3 locationsNCT06959082
Recruiting
Phase 2
Atorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck Cancer
Head and Neck CancerHearing Loss
National Institute on Deafness and Other Communication Disorders (NIDCD)224 enrolled5 locationsNCT04915183
Recruiting
Phase 2
A Study Testing Emactinib Sulfate With Chemotherapy and Immunotherapy Before Surgery for Advanced Head and Neck Cancer
Head and Neck Cancer Squamous Cell Carcinoma
Second Affiliated Hospital, School of Medicine, Zhejiang University76 enrolled1 locationNCT07457346
Recruiting
Phase 2
Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer
Head and Neck CarcinomaHead and Neck CancerOral Cancer+1 more
Case Comprehensive Cancer Center30 enrolled1 locationNCT06627270
Recruiting
Phase 2
Response-Adaptive Treatment in Untreated Locoregional HPV-Negative Head and Neck Cancer
Head and Neck CancerHPV
University of Chicago38 enrolled1 locationNCT07065630
Recruiting
Phase 1Phase 2
TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers
Head and Neck CancerHPV Positive Oropharyngeal Squamous Cell CarcinomaHuman Papilloma Virus+1 more
University of Chicago98 enrolled1 locationNCT05108870
Recruiting
Phase 2
A Single-center Phase II Study to Investigate the Immune Maintenance Therapy Pattern in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Who Have Achieved MPR After Neoadjuvant Immunotherapy Combined With Chemotherapy
Head and Neck Cancer
Tianjin Medical University Cancer Institute and Hospital268 enrolled1 locationNCT06208826
Recruiting
Phase 2
Iparomlimab and Tuvonralimab Plus Hypofractionated Radiotherapy and Chemotherapy for HAHNSCC
Head and Neck CancerRadiotherapyAnti-PD-1/CTLA-4 Antibody
Second Affiliated Hospital, School of Medicine, Zhejiang University27 enrolled1 locationNCT07447570
Recruiting
Phase 2
A Study of Decreasing Radiation Therapy and Chemotherapy in People With Head and Neck Cancer
Head and Neck CarcinomaHead and Neck CancerHead and Neck Squamous Cell Carcinoma+1 more
Memorial Sloan Kettering Cancer Center12 enrolled6 locationsNCT05544136
Recruiting
Phase 2
Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial
Breast CancerSarcomaLung Cancer+2 more
University of California, Irvine24 enrolled1 locationNCT07447050