Phase 1 Head and Neck Cancer Clinical Trials
31 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 31 trials
Recruiting
Phase 1
A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors
Head and Neck CancerHNSCCColo-rectal Cancer+4 more
ALX Oncology Inc.170 enrolled7 locationsNCT07085091
Recruiting
Phase 1
Phase I Study of Preconditioning Radiation Therapy With IL-15 Transduced TGFBR2 KO CAR.TROP2-engineered Cord Blood-derived NK Cells in Patients With Advanced Head and Neck Cancer (RADIANCE-NK)
Head and Neck Cancer
M.D. Anderson Cancer Center33 enrolled1 locationNCT07101432
Recruiting
Phase 1Phase 2
Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent Head and Neck Squamous Cell Carcinoma
Head and Neck CancerRecurrent Head and Neck Squamous Cell Carcinoma
University of Cincinnati40 enrolled1 locationNCT07213934
Recruiting
Phase 1
A Study of Cemiplimab With Chemotherapy and Immunotherapy in People With Head and Neck Cancer
Head and Neck CancerHead and Neck Squamous Cell CarcinomaHNSCC+3 more
Memorial Sloan Kettering Cancer Center40 enrolled7 locationsNCT04722523
Recruiting
Phase 1
Pembrolizumab Plus Ultrasound-Induced Microbubble Cavitation in Head and Neck Cancer
Head and Neck CancerMetastatic Head and Neck CancerRecurrent Head and Neck Cancer+1 more
Thomas Jefferson University6 enrolled1 locationNCT07501650
Recruiting
Phase 1Phase 2
TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers
Head and Neck CancerHPV Positive Oropharyngeal Squamous Cell CarcinomaHuman Papilloma Virus+1 more
University of Chicago98 enrolled1 locationNCT05108870
Recruiting
Phase 1
Dosing Study of Radiation Combined With Tislelizumab and Pamiparib in Patients With Previously Treated Head and Neck Cancer
Head and Neck CarcinomaHead and Neck CancerHead and Neck Squamous Cell Carcinoma+2 more
University of Chicago30 enrolled1 locationNCT05526924
Recruiting
Phase 1Phase 2
Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCC
Head and Neck CancerRecurrentRelapse+1 more
UNC Lineberger Comprehensive Cancer Center33 enrolled1 locationNCT06096038
Recruiting
Phase 1
A Study of SH009 Injection in Patients With Advanced Solid Tumors.
Esophageal CancerBreast Cancer (Locally Advanced or Metastatic)Lung Cancer (NSCLC)+4 more
Nanjing Sanhome Pharmaceutical, Co., Ltd.150 enrolled1 locationNCT07390838
Recruiting
Phase 1
Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer
Head and Neck CancerSolid TumorsHNSCC+3 more
VLP Therapeutics41 enrolled1 locationNCT06736379
Recruiting
Phase 1
Study to Assess the Effect of OCT-598 in Patients With Advanced Solid Tumors
Breast CancerHead and Neck CancerSolid Tumor
Oscotec Inc.51 enrolled3 locationsNCT07358806
Recruiting
Phase 1Phase 2
NT219 Combined With Standard of Care Biologic Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Head and Neck CancerHead and Neck Squamous Cell Carcinoma
University of Colorado, Denver29 enrolled2 locationsNCT06919666
Recruiting
Phase 1Phase 2
A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors
Pancreatic Ductal Adenocarcinoma (PDAC)Colorectal Cancer (CRC)Clear Cell Renal Cell Cancer (ccRCC)+4 more
ITM Oncologics GmbH270 enrolled10 locationsNCT05706129
Recruiting
Phase 1
Thermoradiotherapy for Locally Advanced Head and Neck Cancer Patients
Head and Neck CancerHead and Neck Squamous Cell CarcinomaLaryngeal Cancer+2 more
Erasmus Medical Center30 enrolled1 locationNCT06761937
Recruiting
Phase 1Phase 2
RAPA-201 Therapy of Solid Tumors
Head and Neck CancerEsophageal Squamous Cell CarcinomaSolid Tumor+6 more
Rapa Therapeutics LLC37 enrolled1 locationNCT05144698
Recruiting
Phase 1
Brodalumab in the Treatment of Immune-Related Adverse Events
Breast CancerLiver CancerEsophageal Cancer+15 more
Brian Henick, MD11 enrolled1 locationNCT06673329
Recruiting
Phase 1
PIRATES: Image-guided Hyper-fractioned Dose-escalation With Proton Therapy for Head and Neck Cancer
Head and Neck CancerOropharyngeal Cancer
University Medical Center Groningen17 enrolled1 locationNCT06446713
Recruiting
Phase 1Phase 2
Induction IBI110 and Sintilimab with Chemotherapy in LA HNSCC
Head and Neck CancerHead and Neck Squamous Cell Carcinoma
Fudan University27 enrolled1 locationNCT06494943
Recruiting
Phase 1Phase 2
Ixovex-1 Single Agent and Combination Therapy
Head and Neck CancerSolid Tumor
Psivac Ltd18 enrolled1 locationNCT06549946
Recruiting
Phase 1
Submandibular Gland Stem Cell Transplantation
Head and Neck Cancer
University Medical Center Groningen18 enrolled1 locationNCT04593589