Early Phase 1 Health Clinical Trials
29 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 29 trials
Recruiting
Early Phase 1
The Role of NaV1.8 in Human Pain Models
PainHealthy Volunteer StudyAcute Pain
Medical University of Vienna66 enrolled1 locationNCT07511400
Recruiting
Early Phase 1
The Dosimetry, Safety and Diagnostic Efficacy of ⁶⁸Ga-FC516 in Healthy Subjects and Patients With Prostate Cancer
Prostate CancerHealthy Adult
FindCure Biosciences (ZhongShan) Co., Ltd.10 enrolled1 locationNCT07468708
Recruiting
Early Phase 1
Positron Emission Tomography (PET) Contrast Agent Kinetics and Safety: [18F]-Fluoromannitol
Healthy
St. Jude Children's Research Hospital10 enrolled1 locationNCT07110519
Recruiting
Early Phase 1
Impact of Exogenous Ketones on Breathing in Healthy Volunteers
Healthy Volunteer
Johns Hopkins University20 enrolled1 locationNCT07220122
Recruiting
Early Phase 1
Human Milk Oligosaccharide-Based Synbiotic Supplement for Intestinal Microbiota Dysbiosis
Healthy Volunteers
National Heart, Lung, and Blood Institute (NHLBI)100 enrolled1 locationNCT06615986
Recruiting
Early Phase 1
Single-tracer Multiparametric PET Imaging
Cardiovascular DiseaseHealthy Subjects
University of California, Davis60 enrolled1 locationNCT06014515
Recruiting
Early Phase 1
Chronic Transcutaneous Stimulation to Promote Motor Function and Recovery in Individuals With Paralysis or Paresis
Neurological injuryStrokeHealthy Volunteers+3 more
Northwell Health64 enrolled1 locationNCT04755699
Recruiting
Early Phase 1
SV2A Density Cannabis Use Disorder
HealthyCannabis Use Disorder
Yale University51 enrolled1 locationNCT05472818
Recruiting
Early Phase 1
The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response
Heat StrainHealthy Volunteer StudyKidney Dysfunction
Beth Israel Deaconess Medical Center28 enrolled2 locationsNCT06983730
Recruiting
Early Phase 1
Saccharomyces Boulardii CNCM I-745 on Intestinal Barrier Function
Healthy
Mayo Clinic56 enrolled1 locationNCT05538247
Recruiting
Early Phase 1
First-in-Human Study for the Safety and Evaluation of Two 4R Tau Ligands as Potential PET Radioligands for Imaging Tau Protein in the Brain
Healthy ParticipantsProgressive Supranuclear Palsy (PSP)
Invicro24 enrolled1 locationNCT07348276
Recruiting
Early Phase 1
Single and Multiple Ascending Doses of NTX-253 in Healthy Participants and Participants With Stable Schizophrenia
Healthy ParticipantsSchizophrenia Diagnosis
Neurosterix73 enrolled1 locationNCT07344948
Recruiting
Early Phase 1
Safety and Efficacy of Klotho and Follistatin Gene Therapy
Healthy Adults
Minicircle30 enrolled2 locationsNCT07285629
Recruiting
Early Phase 1
PET Imaging Evaluation of [11C]SY08
Multiple System AtrophyDementia With Lewy BodiesParkinson's Disease+1 more
Massachusetts General Hospital40 enrolled1 locationNCT06098612
Recruiting
Early Phase 1
Cardiometabolic Benefit of Reducing Iatrogenic Hyperinsulinemia Using Insulin Adjunctive Therapy in Type 1 Diabetes
Healthy VolunteerMODY2 DiabetesType 1 Diabetes Mellitus+1 more
Vanderbilt University Medical Center27 enrolled1 locationNCT06609356
Recruiting
Early Phase 1
Researching Economical Adjuvants to Cancer Therapy
Healthy Participants
Florida State University60 enrolled1 locationNCT07305259
Recruiting
Early Phase 1
Safety and Efficacy of ONT01 in Lupus
Systemic Lupus ErythematosusSLELupus Nephritis (LN)+5 more
Hospital for Special Surgery, New York61 enrolled1 locationNCT07107659
Recruiting
Early Phase 1
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction
Type 2 DiabetesHealthy Aging
Medical College of Wisconsin60 enrolled1 locationNCT05593549
Recruiting
Early Phase 1
Mapping Auricular Vagus Nerve Circuitry
Healthy
Massachusetts General Hospital50 enrolled1 locationNCT00200889
Recruiting
Early Phase 1
The Effect of Oral Oxytocin and Atosiban on Top-down Attention ( OTAtosiban )
Healthy Adult Male
University of Electronic Science and Technology of China250 enrolled1 locationNCT07140237