Hepatoblastoma Clinical Trials

12 recruiting

Hepatoblastoma Trials at a Glance

15 actively recruiting trials for hepatoblastoma are listed on ClinicalTrialsFinder across 6 cities in 5 countries. The largest study group is Phase 1 with 8 trials, with the heaviest enrollment activity in Washington D.C., Houston, and Memphis. Lead sponsors running hepatoblastoma studies include St. Jude Children's Research Hospital, Sun Yat-sen University, and Children's Oncology Group.

Browse hepatoblastoma trials by phase

Treatments under study

About Hepatoblastoma Clinical Trials

Looking for clinical trials for Hepatoblastoma? There are currently 12 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Hepatoblastoma trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Hepatoblastoma clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 115 of 15 trials

Recruiting
Phase 2

Agnostic Therapy in Rare Solid Tumors

Cancer of Unknown PrimarySoft Tissue SarcomaCholangiocarcinoma+38 more
Instituto do Cancer do Estado de São Paulo28 enrolled8 locationsNCT06638931
Recruiting
Phase 1

B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)

Soft Tissue SarcomaMelanomaCarcinoma+13 more
St. Jude Children's Research Hospital48 enrolled1 locationNCT04897321
Recruiting
Phase 1

Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies

Germ Cell TumorEwing SarcomaNeuroblastoma+3 more
New York Medical College30 enrolled1 locationNCT04308330
Recruiting
Phase 1Phase 2

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

Recurrent Malignant Solid NeoplasmRefractory Malignant Solid NeoplasmRecurrent Solid Tumor+19 more
St. Jude Children's Research Hospital90 enrolled10 locationsNCT04901702
Recruiting

Relapsed and Refractory Hepatoblastoma: A Prospective Registry and Liver Tumor Research Consortium Initiative

Refractory HepatoblastomaRelapsed Hepatoblastoma
Children's Hospital Medical Center, Cincinnati500 enrolled1 locationNCT05556642
Recruiting
Phase 1Phase 2

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

Ovarian CarcinomaColorectal CarcinomaMelanoma+19 more
Children's Oncology Group147 enrolled21 locationsNCT04851119
Recruiting
Phase 1

Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells

Hepatocellular CarcinomaRhabdomyosarcomaWilms Tumor+7 more
Seattle Children's Hospital21 enrolled1 locationNCT07148050
Recruiting
Phase 2

A Prospective Multicenter Clinical Study of SCCG Protocol and ctDNA 5hmc in Predicting the Chemotherapy Sensitivity and Monitoring the Recurrence and Metastasis of Hepatoblastoma in Children and Adolescents

Hepatoblastoma
Sun Yat-sen University100 enrolled2 locationsNCT07300449
Recruiting
Phase 1

Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells

Hepatocellular CarcinomaRhabdomyosarcomaWilms Tumor+5 more
Baylor College of Medicine21 enrolled1 locationNCT06198296
Recruiting
Phase 1

Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors

Solid TumorsEwing SarcomaNeuroblastoma+3 more
Valent Technologies, LLC20 enrolled8 locationsNCT04337177
Recruiting
Not Applicable

Pucotenlimab Combined With Lenvatinib and Chemotherapy in the Treatment of Advanced, Relapsed/Refractory Hepatoblastoma in Children

Pediatric CancerHepatoblastoma
Sun Yat-sen University24 enrolled1 locationNCT07188311
Recruiting

Molecular Basis of Pediatric Liver Cancer

Hepatocellular CarcinomaLiver Malignant TumorsHepatoblastoma+3 more
University of Pittsburgh1,600 enrolled1 locationNCT03959800
Recruiting

A French Multicenter Observational Retrospective Study of Rare Primary Liver Cancers

CholangiocarcinomaHepatoblastomaFibrolamellar Carcinoma+7 more
Federation Francophone de Cancerologie Digestive150 enrolled40 locationsNCT06541652
Recruiting
Phase 3

A Multi-institutional Study for Treatment of Children With Newly Diagnosed Hepatoblastoma Using a Modified PHITT Strategy

Hepatoblastoma
Shanghai Children's Medical Center330 enrolled1 locationNCT04478292
Recruiting
Phase 1Phase 2

ET140203 T Cells in Pediatric Subjects With Hepatoblastoma, HCN-NOS, or Hepatocellular Carcinoma

Liver CancerMetastatic Liver CancerLiver Neoplasms+3 more
Eureka Therapeutics Inc.15 enrolled2 locationsNCT04634357