Phase 1 Immunotherapy Clinical Trials
22 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 22 trials
Recruiting
Phase 1
Controlled Cold Exposure Combined With PD-1/PD-L1 Immunotherapy in Solid Tumors (NIVALIS)
Solid TumorsImmunotherapyCold Exposure+1 more
West China Hospital24 enrolled1 locationNCT07538479
Recruiting
Phase 1
Phase I, Open-labeled, Dose-escalation, Dose-expansion Study Evaluating the Safety, Tolerance, Pharmacokinetics, and Activity of IUAb190708 in Patients With Advanced or Recurrent Solid Tumors
Solid Tumor CancerSolid Tumor Cancer Treatment With Immunotherapy
Jun Zhou90 enrolled6 locationsNCT07584954
Recruiting
Phase 1
Efficacy and Safety of Autologous Peptide-induced Active Immunity in AML Maintenance Therapy
Acute Myeloid LeukemiaMaintenance TherapyPersonalized Active Immunotherapy
Fujian Medical University Union Hospital90 enrolled1 locationNCT07551037
Recruiting
Phase 1Phase 2
VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma
Esophageal CancerPancreatic CancerHead and Neck Squamous Cell Carcinoma (HNSCC)+22 more
VM Oncology, LLC242 enrolled15 locationsNCT03556228
Recruiting
Phase 1
VSV-02 Compassionate Use in Advanced Solid Tumors
Breast CancerLung CancerMelanoma+3 more
The First Affiliated Hospital of Xinxiang Medical College6 enrolled1 locationNCT07260591
Recruiting
Phase 1Phase 2
Personalized Neoantigen Peptide Vaccines for Solid Tumors
Solid TumorsAdvanced CancerRecurrent Cancer+2 more
Seqker Biosciences, Inc.10 enrolled2 locationsNCT07002203
Recruiting
Phase 1Phase 2
Hypofractionated Radiotherapy Combined With Immunochemotherapy for Conversion Treatment of Gastroesophageal Junction Adenocarcinoma
ChemotherapyGastroesophageal Junction AdenocarcinomaImmunotherapy+1 more
West China Hospital88 enrolled4 locationsNCT07072351
Recruiting
Phase 1Phase 2
A Study of ABT-301 Plus Tislelizumab With Bevacizumab in pMMR/Non-MSI-H Locally Advanced or mCRC
ImmunotherapyColorectal Cancer MetastaticColorectal Cancer (CRC)+1 more
Anbogen Therapeutics, Inc.66 enrolled15 locationsNCT07244705
Recruiting
Phase 1Phase 2
NEoadjuvant Chemotherapy and Immunotherapy for a Selected Group of Inoperable Pleural Mesothelioma Patients (NECIM): a Feasibility Study
Mesothelioma; PleuraNeoadjuvant ChemoimmunotherapyPleural Epithelioid Mesothelioma
University Hospital, Antwerp37 enrolled1 locationNCT07121374
Recruiting
Phase 1Phase 2
A Clinical Trial of Neoadjuvant Targeted Therapy, Immunotherapy, and Lysogenic HSV-Based Virotherapy in Resectable Head and Neck Squamous Cell Carcinoma
Neoadjuvant TherapyHNSCCTargeted Therapy+2 more
West China Hospital29 enrolled1 locationNCT07010120
Recruiting
Phase 1
A Phase I Trial of Tumor-Associated Lymph Node T-Cell Injection With Advanced Malignant Solid Tumors
Advanced Solid TumorImmunotherapyTumor Associated Lymph Node T Cell+1 more
Guangzhou FineImmune Biotechnology Co., LTD.32 enrolled1 locationNCT06716619
Recruiting
Phase 1Phase 2
Induction Toripalimab and Chemotherapy in Locally Advanced Cervical Cancer
Cervical CancerImmunotherapyInduction Chemotherapy
Tianjin Medical University Cancer Institute and Hospital20 enrolled1 locationNCT06093438
Recruiting
Phase 1
A Clinical Study on Neoadjuvant Treatment of Resectable Head and Neck Squamous Carcinoma With Immune-targeted Therapy and Lysogenic HSV Virus
Neoadjuvant TherapyHNSCCTargeted Therapy+2 more
West China Hospital21 enrolled1 locationNCT06741982
Recruiting
Phase 1
Phase I Clinical Study of Tumor-associated Lymph Node T Cell Therapy for Advanced Solid Tumors
Advanced Solid TumorImmunotherapyTumor Associated Lymph Node T Cell
Guangzhou FineImmune Biotechnology Co., LTD.23 enrolled1 locationNCT06302062
Recruiting
Phase 1
GPC3/Mesothelin/Claudin18.2/GUCY2C/B7-H3/PSCA/PSMA/MUC1/TGFβ/HER2/Lewis-Y/AXL/EGFR-CAR-T Cells Against Cancers
Lung CancerCancerImmunotherapy+1 more
Second Affiliated Hospital of Guangzhou Medical University30 enrolled2 locationsNCT03198052
Recruiting
Phase 1Phase 2
Induced-T Cell Like NK Cellular Immunotherapy for Cancer Lack of MHC-I
Anti-cancer Cell ImmunotherapyT Cell and NK Cell
Second Affiliated Hospital of Guangzhou Medical University60 enrolled1 locationNCT03882840
Recruiting
Phase 1
GPC3-CAR-T Cells for Immunotherapy of Cancer With GPC3 Expression
Hepatocellular CarcinomaImmunotherapySquamous Cell Lung Cancer+3 more
Second Affiliated Hospital of Guangzhou Medical University30 enrolled2 locationsNCT03198546
Recruiting
Phase 1Phase 2
Concurrent Chemoradiotherapy Followed by PD-1 Inhibitor in Advanced Cervical Cancer
Locally Advanced Cervical CarcinomaImmunotherapyConcurrent Chemoradiotherapy
RenJi Hospital20 enrolled1 locationNCT06391190
Recruiting
Phase 1
Precision Therapy for Solid Tumors: Synergistic CDK4/6 Inhibition and Anti-VEGF Targeting LncRNA
Breast CancerColorectal, CancerOvarian Cancer+7 more
Lebanese University50 enrolled2 locationsNCT06307249
Recruiting
Phase 1
Clinical Study of PSMA-targeted CAR-T Cells in the Treatment of Castration-resistant Prostate Cancer
Immunotherapy
The Affiliated Hospital of Xuzhou Medical University20 enrolled1 locationNCT05354375