Phase 1 Insulin Clinical Trials
16 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–16 of 16 trials
Recruiting
Phase 1
Effect of Insulin Lowering on Lipogenesis
ObesityInsulin ResistanceNon-Alcoholic Fatty Liver Disease+2 more
Columbia University25 enrolled1 locationNCT07403604
Recruiting
Phase 1
Human Models of Selective Insulin Resistance: Alpelisib, Part I
Insulin ResistanceNon-Alcoholic Fatty Liver DiseaseOverweight and Obesity+1 more
Columbia University32 enrolled1 locationNCT06354088
Recruiting
Phase 1
A Study to Evaluate the Effect of Retatrutide on Insulin Secretion and Insulin Sensitivity in Adult Participants With Type 2 Diabetes Mellitus
Diabetes MellitusInsulin Sensitivity
Eli Lilly and Company95 enrolled1 locationNCT06982859
Recruiting
Phase 1
Graded Insulin Suppression Test P&F
ObesityInsulin ResistanceHealthy+1 more
Columbia University15 enrolled1 locationNCT06592261
Recruiting
Phase 1
Diazoxide Suppression Test P&F Study
ObesityInsulin ResistanceHyperinsulinemia
Columbia University10 enrolled1 locationNCT06606327
Recruiting
Phase 1
MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes
Cardiovascular DiseasesEndothelial DysfunctionType 1 Diabetes+2 more
Kalie Tommerdahl60 enrolled2 locationsNCT05065372
Recruiting
Phase 1
Mitigating the Pro-inflammatory Phenotype of Obesity
ObesityInsulin ResistanceBlood Pressure+3 more
University of Kansas Medical Center60 enrolled1 locationNCT04934228
Recruiting
Phase 1
Metabolic Effects of Angiotensin-(1-7)
ObesityInsulin ResistanceHypertension+1 more
Vanderbilt University26 enrolled1 locationNCT02646475
Recruiting
Phase 1
Study to Evaluate Biomarkers and Safety of Dapagliflozin Concomitant with Neoadjuvant Therapy
Breast CancerHER2-negative Breast CancerHyperinsulinism
Yale University20 enrolled1 locationNCT05989347
Recruiting
Phase 1Phase 2
Hyperbaric Oxygen Therapy on Insulin Resistance in Postmenopause
Insulin Resistance Syndrome
Cairo University40 enrolled1 locationNCT06806345
Recruiting
Phase 1
Fluorodopa F 18 in Congenital Hyperinsulinism and Insulinoma
Congenital HyperinsulinismInsulinoma
Cook Children's Health Care System250 enrolled1 locationNCT02021604
Completed
Phase 1
Comparative assessment of the absorption of a generic formulation of Inhaled Insulin against the innovators Humalog KwikPen for injection and the AFREZZA Inhalation Powder Cartridge conducted under fasting conditions in healthy male and female volunteers
Pharmacokinetic and pharmacodynamic study conducted in healthy volunteers comparing three formulations of Insulin with no health condition or problem studied.
Insulin is a medicine that is used to lower blood glucose.
Zenith Technology Corp Ltd18 enrolled1 locationACTRN12615001100583
Recruiting
Phase 1
Effect of Fucoidan on glucose control and markers of cardiometabolic health after chronic dosing
Insulin Resistance/sensitivityHypercholesterolaemiaObesity+3 more
University of Tasmania.80 enrolled1 locationACTRN12614000495628
Completed
Phase 1
A Randomised, Placebo Controlled, Double-Blind, Single Ascending Dose and Multiple Dose Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Subcutaneous Doses of ATL1103 in Healthy Adult Male Subjects
ATL1103 is being developed as a potential treatment for diseases of excessive growth hormone and insulin-like growth hormone (IGF)-I action, including the condition acromegaly.
Antisense Therapeutics Limited36 enrolled1 locationACTRN12611000854932
Completed
Phase 1
Fibre, protein and insulin resistance diet study
Insulin resistance in healthy overweight women.Metabolic syndrome in healthy overweight women.Diabetes prevention in healthy overweight women.
Dr Kirsten McAuley72 enrolled1 locationACTRN12607000154404
Completed
Phase 1
Post-exercise Nutrition Recovery and Immune Response Study
Blood glucose and insulin and immune responses.
Dr Tracy Perry28 enrolled1 locationACTRN12605000168651