Phase 1 Kidney Disease Clinical Trials
29 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 29 trials
Recruiting
Phase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4248 in Healthy Participants and Participants With Chronic Kidney Disease and Type 2 Diabetes and to Assess Home Measurements of Creatinine in a Non Interventional Cohort
Chronic Kidney Disease
AstraZeneca124 enrolled5 locationsNCT07024823
Recruiting
Phase 1Phase 2
Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease
Heart FailureChronic Kidney DiseasesKidney Diseases+1 more
Northwestern University60 enrolled1 locationNCT05719714
Recruiting
Phase 1
A Phase I Clinical Trial to Evaluate CMS-D017 Following Single and Multiple Doses in Healthy Participants
Paroxysmal Nocturnal Hemoglobinuria, PNHComplement-mediated Kidney Disease
Shenzhen Kangzhe Biotechnology Co., Ltd.88 enrolled1 locationNCT07462780
Recruiting
Phase 1
Safety and Efficacy of SC101 Via Perirenal Fat Injection for Resistant Hypertension in Patients With Moderate to Severe Chronic Kidney Disease
Resistant Arterial HypertensionChronic Kidney Disease (Stage 3-4)
The First Affiliated Hospital with Nanjing Medical University3 enrolled1 locationNCT07483372
Recruiting
Phase 1Phase 2
A Study to Investigate the Safety, Tolerability, and Preliminary Efficacy With AION-301 Administered by Intravenous Infusion Compared With Placebo Administered by Intravenous Infusion Investigational Intervention in Participants Aged 35 to 75 Years of Age With Chronic Kidney Disease (CKD)
Chronic Kidney Disease Stage 3
AION Healthspan, Inc.36 enrolled2 locationsNCT06721143
Recruiting
Phase 1
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of OJR520 in Healthy Volunteers and Participants With Chronic Kidney Disease
Chronic Kidney Disease
Novartis Pharmaceuticals112 enrolled2 locationsNCT07235059
Recruiting
Phase 1
A Study of REGEND003 on Patients With Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD)
Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD)
Regend Therapeutics15 enrolled1 locationNCT07275788
Recruiting
Phase 1
A Study of Eloralintide (LY3841136) in Participants With Renal Impairment and in Participants With Normal Renal Function
Kidney Disease
Eli Lilly and Company28 enrolled2 locationsNCT07426380
Recruiting
Phase 1
Safety, Tolerability and Pharmacokinetics of AZD1613 in Adults With Autosomal Dominant Polycystic Kidney Disease
Autosomal Dominant Polycystic Kidney Disease
AstraZeneca40 enrolled15 locationsNCT07228364
Recruiting
Phase 1Phase 2
A Study to Investigate IGT-303 in Healthy Volunteers and Participants With Chronic Kidney Disease
Healthy VolunteersChronic Kidney Disease
Ingenia Therapeutics INC94 enrolled1 locationNCT07231679
Recruiting
Phase 1
Remimazolam Infusion in Kidney Transplant Patients: A Multicenter Study
Chronic Kidney DiseasesRenal Transplantation
Qianfoshan Hospital30 enrolled1 locationNCT07045467
Recruiting
Phase 1
A Study to Evaluate the Safety, Tolerability, PK and PD of AP303 in DKD Patients
Diabetic Kidney Disease
Alebund Pharmaceuticals18 enrolled1 locationNCT06666283
Recruiting
Phase 1
A Study to Evaluate the Safety, Tolerability, and Effects on Blood and Urine Markers of Single Ascending Dose of GSK4771261 in Healthy Participants and Participants With Autosomal Dominant Polycystic Kidney Disease
Kidney Disease
GlaxoSmithKline84 enrolled14 locationsNCT06734234
Recruiting
Phase 1
A Study to Evaluate the Safety, Tolerability and PK of SK-08
Chronic Kidney Disease(CKD)
Consun Pharmaceutical Group48 enrolled1 locationNCT07021157
Recruiting
Phase 1
MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes
Cardiovascular DiseasesEndothelial DysfunctionType 1 Diabetes+2 more
Kalie Tommerdahl60 enrolled2 locationsNCT05065372
Withdrawn
Phase 1
A Phase 1 Randomized, Double-blind, Placebo-controlled Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of MZE782 in Healthy Adults
Chronic Kidney DiseasePhenylketonuria
Maze Therapeutics24 enrolled1 locationACTRN12625000488404
Recruiting
Phase 1Phase 2
Probiotic Supplementation and Disease Progression in CKD: A Randomized Trial
Kidney Disease, ChronicRenal Insufficiency, ChronicGut Dysbiosis+1 more
Mansoura University72 enrolled1 locationNCT06863194
Recruiting
Phase 1
Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intravenous Infusion for CKD
Chronic Kidney Diseases
The Foundation for Orthopaedics and Regenerative Medicine20 enrolled1 locationNCT05018845
Recruiting
Phase 1
Inflammation REduction to Prevent cArdiovascular Injury in Renal Disease (REPAIR)
Chronic Kidney DiseasesRenal Failure
Hamilton Health Sciences Corporation200 enrolled3 locationsNCT06203977
Recruiting
Phase 1
Sympatholysis in Chronic Kidney Disease
Chronic Kidney Disease
Emory University110 enrolled1 locationNCT02411773