Phase 2 Liver Disease Clinical Trials
33 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 33 trials
Recruiting
Phase 2
Tirzepatide in MetALD
Alcohol Use DisorderMetabolic Alcohol-associated Liver Disease
National Institute on Alcohol Abuse and Alcoholism (NIAAA)120 enrolled1 locationNCT07046819
Recruiting
Phase 2
SMART Diets for MASLD
Metabolic Dysfunction-Associated Steatotic Liver Disease
Michigan State University102 enrolled1 locationNCT07459504
Recruiting
Phase 2
Digoxin In NASH (CODIN)
MASLDMASH - Metabolic Dysfunction-Associated SteatohepatitisFatty Liver Disease+5 more
Yale University144 enrolled2 locationsNCT06588699
Recruiting
Phase 2
Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)
Non-Alcoholic Fatty Liver DiseaseNon Alcoholic Steatohepatitis
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)84 enrolled1 locationNCT03884075
Recruiting
Phase 1Phase 2
Intestinal Microbiota Transplant in Alcohol-Associated Liver Disease
CirrhosisAlcohol Use DisorderLiver Disease; Alcohol-Related
Virginia Commonwealth University80 enrolled2 locationsNCT05548452
Recruiting
Phase 2
A Study to Evaluate the Use of Resmetirom in Participants With MASLD and HIV
HIV (Human Immunodeficiency Virus)MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
Naga P. Chalasani120 enrolled10 locationsNCT07143968
Recruiting
Phase 2
Evaluating the Safety and Efficacy of Carbocisteine in the Treatment of Nonalcoholic Fatty Liver Disease Patients
Non-Alcoholic Fatty Liver Disease
Tanta University46 enrolled1 locationNCT06863376
Recruiting
Phase 2
Investigation of the Efficacy of a Probiotic Mixture in Moderate Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Mechanistic Trial
MASLD - Metabolic Dysfunction-Associated Steatotic Liver DiseaseFatty Liver Disease, NonalcoholicOverweight (BMI > 25)
AB Biotics, SA60 enrolled1 locationNCT07193927
Recruiting
Phase 1Phase 2
A Study to Evaluate ALN-CIDEB in Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease or With Metabolic Dysfunction-Associated Steatohepatitis (MASLD/MASH)
Metabolic Dysfunction-Associated Steatotic Liver DiseaseMetabolic Dysfunction-Associated Steatohepatitis
Regeneron Pharmaceuticals132 enrolled3 locationsNCT06836609
Recruiting
Phase 1Phase 2
A Trial to Learn if ALN-PNP is Safe and Well Tolerated in Healthy Adults and Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Healthy VolunteersMetabolic dysfunction–associated steatotic liver disease (MASLD)
Regeneron Pharmaceuticals172 enrolled6 locationsNCT05648214
Recruiting
Phase 2
A Study to Investigate the Safety and Efficacy of GSK4532990 Compared With Placebo in Adult Participants Aged 18 to 70 Years With Alcohol-related Liver Disease
Liver Diseases, Alcoholic
GlaxoSmithKline393 enrolled131 locationsNCT06613698
Recruiting
Phase 2
RESTORE TRIAL: A Phase 2 Study Evaluating the Efficacy and Safety of Pemvidutide in the Treatment of Alcohol-Associated Liver Disease (ALD)
Alcohol Liver Disease
Altimmune, Inc.100 enrolled43 locationsNCT07009860
Recruiting
Phase 2
Tesamorelin for Reduction of Liver Fat in Adults With Fatty Liver Disease (Mock Study)
Hepatic SteatosisNonalcoholic SteatohepatitisMetabolic-Associated Steatotic Liver Disease
Hudson Biotech120 enrolled1 locationNCT07481734
Recruiting
Phase 1Phase 2
Immune Tolerance Induction After Liver Transplantation
Liver TransplantationEnd Stage Liver DiseaseImmune Tolerance+6 more
University of California, Los Angeles12 enrolled1 locationNCT07269041
Recruiting
Phase 1Phase 2
A Study to Evaluate the Safety and Efficacy of PN20 in the Treatment of Thrombocytopenia in Patients With Chronic Liver Disease Undergoing an Elective Procedure
Thrombocytopenia Associated With Chronic Liver Disease
Chongqing Peg-Bio Biopharm Co., Ltd.54 enrolled8 locationsNCT07446491
Recruiting
Phase 1Phase 2
RTX001 Autologous Engineered Macrophages for Liver Cirrhosis
Liver DiseasesCirrhosis, LiverDecompensated Liver Cirrhosis+5 more
Resolution Therapeutics Limited30 enrolled14 locationsNCT06823713
Recruiting
Phase 2
Milk Thistle Clinical Trial in Pediatric NAFLD
Non-alcoholic Fatty Liver Disease NAFLD
University Hospitals Cleveland Medical Center20 enrolled1 locationNCT06477146
Recruiting
Phase 2
Mechanisms of SGLT2 Inhibition in Pediatric Steatotic Liver Disease
Non-Alcoholic Fatty Liver Disease
Justin Ryder40 enrolled1 locationNCT06355310
Recruiting
Phase 2
A Trial to Evaluate the Efficacy, Safety, PK, and PD of HP515 in Non - Alcoholic Fatty Liver Disease ( NASH/MASH )
NAFLD - Non-Alcoholic Fatty Liver Disease
Hinova Pharmaceuticals Inc.80 enrolled2 locationsNCT07308548
Recruiting
Phase 2
Effect of Ketone Esters on Liver Fat Content and Metabolic Function
ObesityOverweight (BMI > 25)MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
Washington University School of Medicine40 enrolled1 locationNCT07097506