Phase 1 Malignant Neoplasm Clinical Trials
42 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 42 trials
Recruiting
Phase 1Phase 2
Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive to Hormonal Therapy
Stage IVB Prostate Cancer AJCC v8Metastatic Malignant Neoplasm in the BoneMetastatic Castration-Resistant Prostate Carcinoma+1 more
National Cancer Institute (NCI)90 enrolled32 locationsNCT04071236
Recruiting
Phase 1Phase 2
A Study of Pembrolizumab in Japanese Pediatric Participants With Solid Tumors or Lymphomas and Japanese Adult Participants With Merkel Cell Carcinoma (MK-3475-G21/KEYNOTE-G21)
LymphomaMalignant NeoplasmCarcinoma, Merkel Cell
Merck Sharp & Dohme LLC20 enrolled3 locationsNCT07302347
Recruiting
Phase 1Phase 2
NBM-BMX Administered Orally to Patients With Solid Tumors or Newly Diagnosed Glioblastoma
Malignant NeoplasmMalignant Neoplasm of Brain
Novelwise Pharmaceutical Corporation79 enrolled4 locationsNCT06012695
Recruiting
Phase 1Phase 2
A Study of TSN1611 Treating Patients With Advanced Solid Tumors Harboring KRAS G12D Mutation
Malignant Neoplasm
Tyligand Pharmaceuticals (Suzhou) Limited440 enrolled19 locationsNCT06385925
Recruiting
Phase 1Phase 2
First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia
Acute Lymphoblastic LeukemiaAcute Myeloid LeukemiaAdvanced Malignant Neoplasm+4 more
Kura Oncology, Inc.263 enrolled56 locationsNCT04067336
Recruiting
Phase 1
Trial of Stereotactic HYpofractionateD RadioAblative (HYDRA) Treatment of Laryngeal Cancer
Malignant Neoplasms of Respiratory and Intrathoracic OrgansSquamous Cell Carcinoma of the Larynx
M.D. Anderson Cancer Center11 enrolled1 locationNCT03114462
Recruiting
Phase 1Phase 2
A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)
Malignant Neoplasm
Merck Sharp & Dohme LLC50 enrolled59 locationsNCT06941272
Recruiting
Phase 1
A Clinical Study of MK-4716 in People With Certain Solid Tumors (MK-4716-001)
Malignant Neoplasm
Merck Sharp & Dohme LLC250 enrolled15 locationsNCT07247110
Recruiting
Phase 1Phase 2
Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal Metastases
Resectable SarcomaMetastatic Malignant Neoplasm in the LungMetastatic Bone Sarcoma+2 more
Roswell Park Cancer Institute99 enrolled1 locationNCT03965234
Recruiting
Phase 1
Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine and Cisplatin for the Treatment of Biliary Tract Cancer Patients With Peritoneal Metastases
Intrahepatic CholangiocarcinomaGallbladder CarcinomaMetastatic Malignant Neoplasm in the Peritoneum+5 more
City of Hope Medical Center12 enrolled1 locationNCT05285358
Recruiting
Phase 1Phase 2
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
Ovarian CancerEndometrial CancerProstate Cancer+5 more
PMV Pharmaceuticals, Inc300 enrolled76 locationsNCT04585750
Recruiting
Phase 1
Intraperitoneal Oxaliplatin and Fluorouracil for the Treatment of Patients With Peritoneal Metastases From Colorectal Cancer
Metastatic Colorectal CarcinomaStage IV Colorectal Cancer AJCC v8Metastatic Malignant Neoplasm in the Peritoneum
Arjun Mittra24 enrolled2 locationsNCT06269978
Recruiting
Phase 1
A Study to Assess CLBR001+ABBV-461 in Subjects With Locally Advanced or Metastatic Breast Cancer
Breast Cancer MetastaticLocally Advanced Breast Cancer (LABC)Malignant Neoplasm of Breast
Calibr, a division of Scripps Research20 enrolled5 locationsNCT06878248
Recruiting
Phase 1Phase 2
CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma
Recurrent Malignant Solid NeoplasmRefractory Malignant Solid NeoplasmRecurrent Lymphoma+7 more
Children's Oncology Group63 enrolled34 locationsNCT04870944
Recruiting
Phase 1Phase 2
A Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced Solid Tumors (MK-3120-002)
Advanced Solid TumorsMalignant Neoplasm
Merck Sharp & Dohme LLC270 enrolled42 locationsNCT06818643
Recruiting
Phase 1Phase 2
Panitumumab-IRDye800 in Detecting Cancer in Participants With Lung Cancer During Surgery
Lung CarcinomaStage IV Lung Cancer AJCC v8Stage IVA Lung Cancer AJCC v8+2 more
Stanford University30 enrolled1 locationNCT03582124
Recruiting
Phase 1Phase 2
Phase I/II Randomized Study of NBTXR3 Activated by Abscopal or RadScopal Radiation in Combination With Immunotherapy (Anti-PD-1/L-1) for Patients With Advanced Solid Malignancies
Metastatic Malignant Solid NeoplasmAdvanced Malignant Solid NeoplasmMetastatic Malignant Neoplasm in the Liver+1 more
M.D. Anderson Cancer Center40 enrolled1 locationNCT05039632
Recruiting
Phase 1
Zr-89 Crefmirlimab Berdoxam and Immuno-Positron Emission Tomography for the Imaging of Patients With Resectable Brain Tumors
Malignant Brain NeoplasmMetastatic Malignant Neoplasm in the BrainMeningioma+1 more
Jonsson Comprehensive Cancer Center20 enrolled1 locationNCT06650163
Recruiting
Phase 1
AU409 for the Treatment of Advanced Primary Liver Cancers or Solid Tumor With Liver Metastatic Disease
Stage III Hepatocellular Carcinoma AJCC v8Stage IV Hepatocellular Carcinoma AJCC v8Refractory Malignant Solid Neoplasm+4 more
University of Southern California36 enrolled2 locationsNCT05791448
Recruiting
Phase 1Phase 2
Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain
Clinical Stage IV Cutaneous Melanoma AJCC v8Metastatic MelanomaPathologic Stage IV Cutaneous Melanoma AJCC v8+1 more
Kari Kendra30 enrolled1 locationNCT05588453