Phase 1 Obesity Clinical Trials
134 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 134 trials
Recruiting
Phase 1
A Study to Evaluate the Safety and Tolerability of Different Doses of CX11 Tablets
Obesity, Overweight
Corxel Pharmaceuticals90 enrolled2 locationsNCT07652047
Recruiting
Phase 1
A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body
ObesityHealthyOverweight
Boehringer Ingelheim80 enrolled1 locationNCT07407348
Recruiting
Phase 1
Examination of How the Duration of Fasting and Temporary Stopping of GLP-1 Medications Affect the Amount of Food Left in the Stomach in People Using Liraglutide (Injected), Semaglutide (Taken by Mouth) or Semaglutide (Injected)
Obesity
Novo Nordisk A/S75 enrolled1 locationNCT07225816
Recruiting
Phase 1
A Study of LY3971297 in Healthy Participants
ObesityHypertensionHealthy
Eli Lilly and Company225 enrolled7 locationsNCT06148272
Recruiting
Phase 1Phase 2
A Study to Evaluate ALN-2232 in Participants With Obesity
Obesity
Alnylam Pharmaceuticals156 enrolled1 locationNCT07463846
Recruiting
Phase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.
ObesityHealthy Participants
AstraZeneca104 enrolled3 locationsNCT07511205
Recruiting
Phase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MBX 4291 in Adult Participants With Obesity
Obesity
MBX Biosciences124 enrolled4 locationsNCT07142707
Recruiting
Phase 1
A Study of Multiple Doses of Orally Administered RO7795081 in Otherwise Healthy Chinese Adult Participants With Obesity or Overweight
Healthy VolunteersOverweight or Obesity
Hoffmann-La Roche30 enrolled2 locationsNCT07499050
Recruiting
Phase 1
A Study Investigating the Safety of RO7795081 and the Effect of RO7795081 on How the Body Processes Pitavastatin and Rosuvastatin in Otherwise Healthy Overweight or Obese Adult Participants
ObesityOverweight
Hoffmann-La Roche40 enrolled1 locationNCT06982131
Recruiting
Phase 1
A Research Study Investigating How a New Medicine NNC0113-5840 Works in People With Overweight or Obesity
ObesityOverweight
Novo Nordisk A/S48 enrolled1 locationNCT07566390
Recruiting
Phase 1
A Research Study Investigating the Effect of NNC0497-0040 in Healthy Participants, Participants With Overweight or Obesity, and Participants With Type 1 Diabetes With Overweight or Obesity
ObesityHealthy VolunteersOverweight+1 more
Novo Nordisk A/S146 enrolled1 locationNCT07578584
Recruiting
Phase 1Phase 2
A Phase 1/2a Study of WVE-007 in Adults Living With Overweight or Obesity
Overweight and Obesity
Wave Life Sciences USA, Inc.296 enrolled6 locationsNCT06842186
Recruiting
Phase 1Phase 2
A Study of MET233 in Combination With MET097 in Individuals With Obesity or Overweight With or Without Diabetes
Obesity and Obesity-related Medical Conditions
Pfizer381 enrolled1 locationNCT06924320
Recruiting
Phase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Single Dose of IBIO-600 in Overweight or Obese Adults
Overweight/Obesity
iBio, Inc.32 enrolled1 locationNCT07487376
Recruiting
Phase 1
A Study in People With Obesity to Test the Effects of BI 456906 Compared With Semaglutide on Glucagon Receptor Activity in the Liver
Obesity
Boehringer Ingelheim30 enrolled1 locationNCT05202353
Recruiting
Phase 1
Graded Insulin Suppression Test P&F
ObesityInsulin ResistanceHealthy+1 more
Columbia University15 enrolled1 locationNCT06592261
Not Yet Recruiting
Phase 1
A trial to assess the safety, tolerability and efficacy of RES-010 in overweight and obese adults without obesity-related comorbidities.
OverweightObesity (Mild)
Resalis Therapeutics Australia Pty Ltd36 enrolled1 locationACTRN12626000615381
Recruiting
Phase 1
A Study of ABBV-295 Subcutaneous Injections to Assess Adverse Events and Pharmacokinetics in Adult Participants With Obesity
Obesity
AbbVie48 enrolled2 locationsNCT07291232
Recruiting
Phase 1
Metabolic Effects of Angiotensin-(1-7)
ObesityInsulin ResistanceHypertension+1 more
Vanderbilt University26 enrolled1 locationNCT02646475
Recruiting
Phase 1
A Research Study Looking Into How Cagrilintide Influences Food Intake and Appetite in People With Overweight or Obesity
ObesityOverweight
Novo Nordisk A/S120 enrolled1 locationNCT07557953