Phase 1 Obesity Clinical Trials
19 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–19 of 19 trials
Recruiting
Phase 1
Understanding the Health Effect of a Bioactive Peptide From Egg: A Pilot Study
High Blood SugarOverweight and ObesityHigh Blood Pressure
University of Alberta28 enrolled1 locationNCT06555393
Recruiting
Phase 1
A Study to Evaluate the Effect of RO7204239 on Insulin Sensitivity and Muscle Composition in Participants With Type 2 Diabetes Mellitus (T2DM) and Overweight or Obesity
ObesityOverweightType 2 Diabetes Mellitus
Hoffmann-La Roche30 enrolled1 locationNCT07137585
Recruiting
Phase 1
A Study Investigating the Safety of RO7795081 and the Effect of RO7795081 on How the Body Processes Pitavastatin and Rosuvastatin in Otherwise Healthy Overweight or Obese Adult Participants
ObesityOverweight
Hoffmann-La Roche40 enrolled1 locationNCT06982131
Recruiting
Phase 1
A Study to Evaluate the Effect of Fasting Duration and Tirzepatide Withholding on the Amount of Food and Fluid in the Stomach in Participants With Type 2 Diabetes Mellitus and Participants With Overweight or Obesity Without Type 2 Diabetes Mellitus
ObesityDiabetes Mellitus, Type 2Overweight
Eli Lilly and Company40 enrolled1 locationNCT07299084
Recruiting
Phase 1
A Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes
ObesityHealthyOverweight+1 more
Eli Lilly and Company201 enrolled5 locationsNCT06945419
Recruiting
Phase 1Phase 2
Sympathetic Mechanisms in Obesity-Crossover Design
ObesityHypertension
Vanderbilt University Medical Center12 enrolled1 locationNCT05312892
Recruiting
Phase 1
A Study of LY3971297 in Healthy Participants
ObesityHypertensionHealthy
Eli Lilly and Company225 enrolled7 locationsNCT06148272
Recruiting
Phase 1Phase 2
A Study of MET233 in Combination With MET097 in Individuals With Obesity or Overweight With or Without Diabetes
Obesity and Obesity-related Medical Conditions
Metsera, a wholly owned subsidiary of Pfizer132 enrolled1 locationNCT06924320
Recruiting
Phase 1
Bioequivalence Study of GZR18 Injection Before and After CMC Change
Obesity&T2D
Gan & Lee Pharmaceuticals.138 enrolled1 locationNCT07355738
Recruiting
Phase 1Phase 2
Study of ARO-ALK7 in Adult Volunteers With Obesity With and Without Type 2 Diabetes Mellitus
ObesityDiabetes Mellitus, Type 2
Arrowhead Pharmaceuticals126 enrolled8 locationsNCT06937203
Recruiting
Phase 1
Phase 1/1b Study of TLC-6740 in Healthy Subjects and Subjects With Obesity, With or Without Diabetes
ObesityType 2 DiabetesHealthy Subjects
OrsoBio, Inc564 enrolled4 locationsNCT05822544
Recruiting
Phase 1
Graded Insulin Suppression Test P&F
ObesityInsulin ResistanceHealthy+1 more
Columbia University15 enrolled1 locationNCT06592261
Recruiting
Phase 1
Diazoxide Suppression Test P&F Study
ObesityInsulin ResistanceHyperinsulinemia
Columbia University10 enrolled1 locationNCT06606327
Recruiting
Phase 1
Pharmacogenetics of Response to GLP1R Agonists
ObesityDiabetes Type 2
University of Maryland, Baltimore600 enrolled1 locationNCT05071898
Recruiting
Phase 1
Metabolic Effects of Angiotensin-(1-7)
ObesityInsulin ResistanceHypertension+1 more
Vanderbilt University26 enrolled1 locationNCT02646475
Recruiting
Phase 1
Physiologic Markers of Cardiometabolic Risk in People With Type 1 Diabetes
ObesityType1diabetes
Yale University15 enrolled1 locationNCT06105931
Recruiting
Phase 1Phase 2
Feasibility of Semaglutide in Advanced Lung Disease
ObesityChronic Obstructive Pulmonary DiseaseInterstitial Lung Disease+2 more
University of Pennsylvania8 enrolled1 locationNCT05746039
Recruiting
Phase 1
The Effectiveness of Astaxanthin Supplementation on the Clinical Symptoms and Cardio-metabolic Profile in Women with Polycystic Ovary Syndrome
PCO - Polycystic OvariesObesity and Obesity-related Medical Conditions
Isfahan University of Medical Sciences44 enrolled1 locationNCT06642363
Recruiting
Phase 1Phase 2
Mechanisms of Semaglutide Therapy in Heart Failure Patients
Heart FailureObesity
University Medical Centre Ljubljana10 enrolled3 locationsNCT06541509