Oral Clinical Trials in Philadelphia, Pennsylvania

22 recruitingPhiladelphia, Pennsylvania

Showing 120 of 22 trials

Recruiting
Phase 2Phase 3

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

Oropharyngeal p16INK4a-Negative Squamous Cell CarcinomaStage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7+6 more
National Cancer Institute (NCI)613 enrolled341 locationsNCT01810913
Recruiting
Phase 2

Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Locally Recurrent Head and Neck Squamous Cell CarcinomaLocally Recurrent Hypopharyngeal Squamous Cell Carcinoma+15 more
National Cancer Institute (NCI)180 enrolled40 locationsNCT07195734
Recruiting
Phase 2

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

Recurrent Head and Neck Squamous Cell CarcinomaRecurrent Oropharyngeal Squamous Cell CarcinomaRecurrent Hypopharyngeal Squamous Cell Carcinoma+2 more
National Cancer Institute (NCI)188 enrolled177 locationsNCT04671667
Recruiting
Phase 2

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

Clinical Stage III Cutaneous Melanoma AJCC v8Clinical Stage IV Cutaneous Melanoma AJCC v8Metastatic Head and Neck Squamous Cell Carcinoma+22 more
National Cancer Institute (NCI)150 enrolled221 locationsNCT05136196
Recruiting
Phase 3

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

Metastatic Head and Neck Squamous Cell CarcinomaStage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8Recurrent Head and Neck Squamous Cell Carcinoma+18 more
National Cancer Institute (NCI)158 enrolled176 locationsNCT06589804
Recruiting
Phase 2

Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery

Recurrent Mucosal MelanomaMucosal MelanomaAnal Melanoma+14 more
National Cancer Institute (NCI)101 enrolled147 locationsNCT05111574
Recruiting
Phase 2Phase 3

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

Tongue Squamous Cell CarcinomaOral Cavity Squamous Cell CarcinomaStage I Lip and Oral Cavity Cancer AJCC v8+9 more
NRG Oncology686 enrolled106 locationsNCT04333537
Recruiting
Phase 1Phase 2

AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy

Mesial Temporal Lobe Epilepsy
UniQure Biopharma B.V.12 enrolled18 locationsNCT06063850
Recruiting
Phase 3

Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))

Mesial Temporal Lobe Epilepsy
Neurona Therapeutics88 enrolled33 locationsNCT05135091
Recruiting
Phase 2

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Head and Neck Squamous Cell CarcinomaStage III Hypopharyngeal Carcinoma AJCC v8Stage III Laryngeal Cancer AJCC v8+13 more
ECOG-ACRIN Cancer Research Group189 enrolled640 locationsNCT02734537
Recruiting
Not Applicable

Evaluating a Strategy to Improve Pre-Anesthesia Care Discussions (My Anesthesia Choice-Hip Fracture)

Hip FracturesFemoral Neck FracturesIntertrochanteric Fractures+1 more
University of Pennsylvania1,881 enrolled6 locationsNCT06438640
Recruiting
Early Phase 1

Localizing Epileptic Networks Using MRI and iEEG

EpilepsyEpilepsy IntractableEpilepsy, Temporal Lobe
University of Pennsylvania290 enrolled1 locationNCT04649008
Recruiting

UPenn Observational Research Repository on Neurodegenerative Disease

Primary Progressive Aphasia(PPA)Frontotemporal Degeneration(FTD)Familial Frontotemporal Lobar Degeneration (fFTLD)+2 more
University of Pennsylvania1,000 enrolled1 locationNCT04715399
Recruiting
Phase 1Phase 2

A Study of PBFT02 in Participants With FTD and Mutations in the Granulin Precursor (GRN) or C9ORF72 Genes

Frontotemporal DementiaFTDFTD-GRN
Passage Bio, Inc.30 enrolled10 locationsNCT04747431
Recruiting
Phase 3

PET Imaging Tau Accumulation in FTLD and Atypical Alzheimer's Using [18F]-PI-2620

Alzheimer DiseaseFrontotemporal Lobar DegenerationCognitively Normal
University of Pennsylvania72 enrolled1 locationNCT05456503
Recruiting

Parkinson's Disease and Movement Disorders Clinical Database

Parkinson DiseaseParkinson Disease DementiaLewy Body Dementia With Behavioral Disturbance+1 more
University of Pennsylvania250 enrolled1 locationNCT04997642
Recruiting
Not Applicable

Using the EHR to Advance Genomic Medicine Across a Diverse Health System

ParagangliomaPheochromocytomaGenetic Predisposition+7 more
University of Pennsylvania1,000 enrolled1 locationNCT06377033
Recruiting

Oropharyngeal Candidiasis (OPC) and S-ECC

Candida InfectionOral Thrush
Temple University70 enrolled1 locationNCT05761197
Recruiting

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

Amyotrophic Lateral SclerosisCorticobasal Degeneration (CBD)Progressive Supranuclear Palsy (PSP)+11 more
Mayo Clinic2,100 enrolled27 locationsNCT04363684
Recruiting
Not Applicable

AI-Based Fidelity Feedback to Enhance CBT

TherapyCognitive Behavioral Therapy
University of Pennsylvania425 enrolled1 locationNCT05340738