Phase 2 Oropharynx Clinical Trials
19 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–19 of 19 trials
Recruiting
Phase 2
Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) Cancer
Squamous Cell Carcinoma of the Head and NeckDrug TherapyOropharynx+2 more
National Cancer Institute (NCI)70 enrolled1 locationNCT06223568
Recruiting
Phase 2
Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States Population
Head and Neck CancerOropharynx CancerHypopharynx Cancer+3 more
Mayo Clinic25 enrolled1 locationNCT06997068
Recruiting
Phase 2
The Minimalist Trial-2
HPV-Related Oropharynx Squamous Cell Carcinoma
Washington University School of Medicine142 enrolled1 locationNCT06702033
Recruiting
Phase 2
A Study on Using Cell-Free Tumor DNA (ctDNA) Testing to Decide When to StartRoutine Treatment in People With Human Papilloma Virus (HPV)- Associated Oropharynx Cancer (OPC)
HPV-Related MalignancyHPV-Related CarcinomaHPV Positive Oropharyngeal Squamous Cell Carcinoma+2 more
Memorial Sloan Kettering Cancer Center30 enrolled8 locationsNCT05307939
Recruiting
Phase 2Phase 3
De-Intensification of Postoperative Radiotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck
Squamous Cell Carcinoma of the LarynxSquamous Cell Carcinoma of the OropharynxSquamous Cell Carcinoma of the Oral Cavity+1 more
University of Erlangen-Nürnberg Medical School508 enrolled1 locationNCT06030440
Recruiting
Phase 1Phase 2
E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers
Cervical CancerAnal CancerPenile Cancer+14 more
Christian Hinrichs15 enrolled2 locationsNCT05639972
Recruiting
Phase 2
E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers
Cervical CancerMetastatic CancerAnal Cancer+18 more
Christian Hinrichs20 enrolled3 locationsNCT05686226
Recruiting
Phase 2
A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC)
Squamous Cell Carcinoma of Head and NeckOral Cavity CancerNasal Cavity Cancer+9 more
Memorial Sloan Kettering Cancer Center40 enrolled7 locationsNCT07063212
Recruiting
Phase 2
HPV DNA-Guided Radiotherapy De-intensification of Head and Neck Squamous Cell Carcinoma
Squamous Cell Carcinoma of the Oropharynx
University of Virginia90 enrolled5 locationsNCT05962242
Recruiting
Phase 2
A Phase II Study for p16+ Oropharyngeal Cancer PerSonalized De-escalation Treatment at University of MIchigan (CuSToMIze)
Oropharyngeal CancerSquamous Cell Carcinoma of the Oropharynx
University of Michigan Rogel Cancer Center150 enrolled1 locationNCT05894083
Recruiting
Phase 2
Personalized Volume-deescalated Elective Nodal Irradiation in Oropharyngeal Head and Neck Squamous Cell Carcinoma
Oropharynx Cancer
University of Zurich120 enrolled5 locationsNCT06563362
Recruiting
Phase 2
Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL)
Head and Neck CancerHead and Neck Squamous Cell CarcinomaHPV Positive Oropharyngeal Squamous Cell Carcinoma+2 more
University of Maryland, Baltimore61 enrolled5 locationsNCT06088381
Recruiting
Phase 2
SURVEILLE-HPV: Evaluation of HPV16 Circulating DNA as Biomarker to Detect the Recurrence, in Order to Improve Post Therapeutic Surveillance of HPV16-driven Oropharyngeal Cancers
Oropharynx Squamous Cell Carcinoma
UNICANCER420 enrolled16 locationsNCT05582122
Recruiting
Phase 2
Neoadjuvant Immunoradiotherapy With Evorpacept and Pembrolizumab in HPVOPC (Human Papilloma Virus Oropharynx Cancer)
Oropharynx Cancer
University of California, San Diego29 enrolled3 locationsNCT05787639
Recruiting
Phase 2
Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer
Oropharynx Cancer
Heath Skinner150 enrolled1 locationNCT05388773
Recruiting
Phase 2
Lymphoscintigraphy Directed Elective Neck Radiation for p16+ Favorable Risk Oropharynx Cancer
Oropharynx Cancer
Fox Chase Cancer Center22 enrolled1 locationNCT05800574
Recruiting
Phase 2
Testing Less Intensive Radiation With Chemotherapy to Treat Low-risk Patients With HPV-positive Oropharyngeal Cancer
HPV Positive Oropharyngeal Squamous Cell CarcinomaOropharynx CancerThroat Carcinoma+1 more
University of Missouri-Columbia28 enrolled1 locationNCT04444869
Recruiting
Phase 2
Adaptive RadioTherapy for OroPharynx Cancer
Radiotherapy Side EffectMRIRadiotherapy; Complications+2 more
Centre hospitalier de l'Université de Montréal (CHUM)120 enrolled2 locationsNCT04901234
Recruiting
Phase 2
Neoadjuvant Chemotherapy and Transoral Robotic Surgery for Oropharyngeal Cancer.
Throat CancerOropharynx CancerTonsil Cancer+1 more
Nader Sadeghi60 enrolled1 locationNCT04277858