Overdose Clinical Trials

4 recruiting

Overdose Trials at a Glance

24 actively recruiting trials for overdose are listed on ClinicalTrialsFinder across 6 cities in 7 countries. The largest study group is Not Applicable with 10 trials, with the heaviest enrollment activity in New York, Baltimore, and Boston. Lead sponsors running overdose studies include Monash Health, Johns Hopkins Bloomberg School of Public Health, and University of Pittsburgh.

Browse overdose trials by phase

Treatments under study

About Overdose Clinical Trials

Looking for clinical trials for Overdose? There are currently 4 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Overdose trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Overdose clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 24 trials

Recruiting
Phase 2Phase 3

Naltrexone for Overdose Prevention

Overdose Accidental
University of California, San Francisco100 enrolled1 locationNCT06633900
Recruiting
Phase 3

Antenatal Magnesium Sulphate in High-Risk Preterm Patients

Cerebral PalsyMagnesium Sulfate Overdose
Cairo University138 enrolled1 locationNCT07524972
Recruiting
Not Applicable

Machine-Learning Prediction and Reducing Overdoses With EHR Nudges

Opioid UseOpioid Overdose
University of Pittsburgh1,350 enrolled1 locationNCT06806163
Recruiting
Not Applicable

Social Network Overdose Prevention and Education Intervention

Drug Overdose
Johns Hopkins Bloomberg School of Public Health600 enrolled1 locationNCT06327061
Recruiting
Not Applicable

Reducing Overdose and Substance Use-related Stigma by Training Non-substance-using Friends and Family Members of People Who Use Opioids to Be Harm Reduction Champions

People Who Use Opioids/People With Opioid Use Disorder (OUD)Opioid Overdose PreventionReduction of Substance Use-related Stigma+2 more
University of Illinois at Chicago600 enrolled1 locationNCT06823453
Recruiting
Not Applicable

A Model to Save Lives Through a Volunteer First Responder Service Providing Antidote Treatment in Opioid Overdose

Opioid Overdose
Region Skane1,000 enrolled1 locationNCT07079241
Recruiting
Phase 4

Vending Machine Naloxone Distribution for Your Community (VENDY)

Harm ReductionOpioid OverdoseNaloxone
University of Colorado, Denver4,000 enrolled3 locationsNCT06429436
Recruiting

Emergency Medicine Peer Outreach Worker Engagement for Recovery

Substance Use DisordersOverdose
University of California, Los Angeles400 enrolled1 locationNCT06320015
Recruiting
Phase 4

Young Houston Emergency Opioid Engagement System

Opioid UseSubstance Use DisordersOpioid-use Disorder+2 more
The University of Texas Health Science Center, Houston250 enrolled1 locationNCT04811014
Recruiting

Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin Poisoning

MetforminDiabetic KetoacidosisDrug Overdose+3 more
Centre Hospitalier de Saint-Denis50 enrolled1 locationNCT07193069
Recruiting

Shelter HArm Reduction Evaluation

Harm ReductionOverdose
NYU Langone Health80 enrolled1 locationNCT07170072
Recruiting
Not Applicable

A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk

Overdose
Boston Medical Center24 enrolled1 locationNCT07022717
Recruiting
Not Applicable

Families Left Behind

Substance Use DisordersGriefGrief Disorder, Prolonged+1 more
RAND340 enrolled4 locationsNCT06854757
Recruiting
Not Applicable

Community-based Education, Navigation, and Support Intervention for Military Veterans

Overdose
New York University300 enrolled1 locationNCT05343169
Recruiting
Not Applicable

A Setting Focus Overdose Prevention Intervention

HIV InfectionsHCVDrug Overdose
Johns Hopkins Bloomberg School of Public Health285 enrolled1 locationNCT05320835
Recruiting
Not Applicable

Developing and Evaluating a Machine-Learning Opioid Overdose Prediction & Risk-Stratification Tool in Primary Care

Opiate OverdoseOpioid-Related DisordersNarcotic-Related Disorders
University of Pittsburgh2,000 enrolled1 locationNCT06810076
Recruiting

Assessment of Methadone Dose Taken

Pain, ChronicDrug Metabolism, Poor, CYP2D6-RelatedMethadone Toxicity+2 more
Cari Health Inc.30 enrolled1 locationNCT05981573
Recruiting
Not Applicable

Improving Availability of Intranasal Naloxone

Opioid Overdose
Hartford Hospital84 enrolled2 locationsNCT05877118
Recruiting

Prospective, Longitudinal Study on FItness DOping in DenmarK

Illicit Drug UseInfertilityMental Health Issue+3 more
Caroline Michaela Kistorp900 enrolled1 locationNCT05599438
Recruiting
Phase 3

The NACSTOP 2 trial: Investigation of the early cessation of N-acetylcysteine in patients following paracetamol overdose.

paracetamol overdose
Monash Health200 enrolled6 locationsACTRN12619001549112