Prophylaxis Clinical Trials

49 recruitingLast updated: May 13, 2026

There are 49 actively recruiting prophylaxis clinical trials across 33 countries. Studies span Not Applicable, Phase 4, Phase 3, Phase 1, Phase 2. Top locations include Paris, France, Chicago, Illinois, United States, San Francisco, California, United States. Updated daily from ClinicalTrials.gov.


Prophylaxis Trials at a Glance

49 actively recruiting trials for prophylaxis are listed on ClinicalTrialsFinder across 6 cities in 33 countries. The largest study group is Not Applicable with 12 trials, with the heaviest enrollment activity in Paris, Chicago, and San Francisco. Lead sponsors running prophylaxis studies include Merck Sharp & Dohme LLC, Georgetown University, and University Hospital, Angers.

Browse prophylaxis trials by phase

Treatments under study

About Prophylaxis Clinical Trials

Looking for clinical trials for Prophylaxis? There are currently 4 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Prophylaxis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Prophylaxis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 49 trials

Recruiting
Phase 3

A Clinical Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-011)

Human Immunodeficiency Virus (HIV)HIV Pre-Exposure Prophylaxis
Merck Sharp & Dohme LLC4,390 enrolled81 locationsNCT07044297
Recruiting
Phase 4

UNCPM 22314 - Pregnancy, Infant and Maternal Health Outcomes Study

Pregnancy RelatedHIV PreventionPre-exposure Prophylaxis
University of North Carolina, Chapel Hill621 enrolled1 locationNCT06158126
Recruiting
Phase 3

A Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-010)

Human Immunodeficiency Virus (HIV)HIV Pre-Exposure Prophylaxis
Merck Sharp & Dohme LLC4,580 enrolled30 locationsNCT07071623
Recruiting
Not Applicable

Integrating HIV Prevention With TB Household Contact Evaluation in Uganda

Tuberculosis (TB)Human Immunodeficiency Virus (HIV) Prophylaxis
University of Washington2,480 enrolled1 locationNCT07119359
Recruiting

Real World Evidence Study of SYN023 in Children Exposed to Rabies

Rabies Post-exposure Prophylaxis
Synermore Biologics (Suzhou) Co., Ltd.232 enrolled6 locationsNCT07327307
Recruiting
Phase 1

A Clinical Study of Letermovir (MK-8228) in Children and Adolescents Who Receive a Kidney Transplant (KT) (MK-8228-077)

Cytomegalovirus Prophylaxis
Merck Sharp & Dohme LLC40 enrolled12 locationsNCT07199465
Recruiting

A Study to Learn More About the Safety of Damoctocog-alfa-pegol When Used in Routine Medical Care in Korean Participants With Hemophilia A

Hemophilia AProphylaxis of BleedingTreatment of Bleeding
Bayer20 enrolled1 locationNCT06222697
Recruiting
Not Applicable

California MEPS Hub

Substance Use Disorder (SUD)HIV PreventionHepatitis C Virus (HCV)+3 more
University of California, Los Angeles318 enrolled3 locationsNCT07433985
Recruiting
Not Applicable

Moon and Sun Brothers: A Community Prevention Intervention (Hermanos de Luna y Sol)

Help-Seeking BehaviorCondomless SexRisky Health Behavior+1 more
San Francisco State University360 enrolled2 locationsNCT07475702
Recruiting

Monitoring of Anti-TFPI in Hemophilia

HemophiliaRebalancing AgentsProphylaxis
Hospices Civils de Lyon11 enrolled2 locationsNCT07101926
Recruiting

Factors Affecting Vaccine Prophylaxis Efficacy in Bone Marrow and Solid Organ Transplant Recipients: Impact on Infection and Mortality Rates

Vaccine Prophylaxis
Fondazione IRCCS Policlinico San Matteo di Pavia200 enrolled1 locationNCT07473999
Recruiting
Phase 3

Study of Lenacapavir as a Once-Yearly Injection for HIV Pre-exposure Prophylaxis (PrEP)

HIV Pre-Exposure Prophylaxis
Gilead Sciences350 enrolled31 locationsNCT07047716
Recruiting
Not Applicable

PathToScale: The PERSIST Trial

Oral Pre-exposure Prophylaxis (PrEP)Long-acting Injectable Cabotegravir for PrEP
Georgetown University9,900 enrolled1 locationNCT07221747
Recruiting

Post-ERCP Pancreatitis - Prophylactic Measures Implementation Study (PEP-PROMIS)

Pancreatitis, AcuteERCPProphylaxis
Branislav Kuncak1,000 enrolled1 locationNCT07244432
Recruiting
Phase 4

Linezolid or Vancomycin Surgical Site Infection Prophylaxis

General SurgeryAntibiotic Prophylaxis
Assistance Publique Hopitaux De Marseille1,160 enrolled1 locationNCT05571722
Recruiting
Phase 4

Enhancing PrEP Uptake and Retention Among Latine TGW and GBM in the South Using Long-Acting Injectable PrEP

HIV Prevention and CareHIV PreventionHIV Prevention Program+2 more
Duke University100 enrolled1 locationNCT07218211
Recruiting

Universal Test and Connect for HIV Service Delivery in South Africa

Human Immunodeficiency VirusPre-exposure ProphylaxisEmergency Department+1 more
Johns Hopkins University2,000 enrolled1 locationNCT06408142
Recruiting
Not Applicable

Impact of Health Education on Knowledge, Attitude and Practice of Post-exposure Prophylaxis

Post Exposure Prophylaxis
Aswan University340 enrolled1 locationNCT07330427
Recruiting
Phase 4

Azithromycin and Ampicillin for Late PPROM

Premature BirthAntibiotic ProphylaxisPrematurity+3 more
Sheba Medical Center311 enrolled1 locationNCT07183462
Recruiting
Not Applicable

Is Valacyclovir Non-inferior to Valganciclovir as CMV and EBV Prophylaxis in Kidney Transplant Recipients? A Single-Center Prospective Randomized Pilot Study

Kidney Transplantation, Cytomegalovirus InfectionsEBV InfectionAntiviral Prophylaxis
National Taiwan University Hospital80 enrolled1 locationNCT07294547