Reflux Disease Clinical Trials

33 recruitingLast updated: July 25, 2026

There are 33 actively recruiting reflux disease clinical trials across 27 countries. Studies span Not Applicable, Phase 3, Phase 4, Early Phase 1, Phase 2. Top locations include Bern, Switzerland, Naples, Italy, Chicago, Illinois, United States. Updated daily from ClinicalTrials.gov.


Reflux Disease Trials at a Glance

33 actively recruiting trials for reflux disease are listed on ClinicalTrialsFinder across 6 cities in 27 countries. The largest study group is Not Applicable with 16 trials, with the heaviest enrollment activity in Bern, Naples, and Chicago. Lead sponsors running reflux disease studies include Cellmedis, Federal State Budgetary Scientific Institution, and Cairo University.

Browse reflux disease trials by phase

Treatments under study

About Reflux Disease Clinical Trials

Looking for clinical trials for Reflux Disease? There are currently 2 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Reflux Disease trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Reflux Disease clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 33 trials

Recruiting
Not Applicable

Mechanistic and Clinical Outcomes of a Surgical Innovation Aimed at Minimizing GERD Associated With VSG (INNOVATE-VSG)

ObesityBariatric SurgeryGastroesophageal Reflux Disease+1 more
University of California, Irvine44 enrolled2 locationsNCT06783751
Recruiting
Not Applicable

New Topical tReatment Options for Symptomatic patiEnts With Nonerosive gastroesophageaL Reflux dIsease (The RELIEF Trial)

GERD (Gastroesophageal Reflux Disease)NERDRegurgitation, Gastric+1 more
Cellmedis50 enrolled1 locationNCT07624383
Recruiting
Not Applicable

QUality of Sleep Improvement With Evening Topical Therapy for Non-Erosive Gastroesophageal Reflux Disease (The QUIET Trial)

GERD (Gastroesophageal Reflux Disease)Non-Erosive Gastro-Esophageal Reflux DiseaseNocturnal Symptoms of GERD+1 more
Cellmedis50 enrolled2 locationsNCT07700342
Recruiting

An Observational Study to Evaluate the Efficacy and Safety of K-CAB Tab./K-CAB ODT(Tegoprazan) in GERD Patients

GERD (Gastroesophageal Reflux Disease)
HK inno.N Corporation5,384 enrolled1 locationNCT07678177
Recruiting
Not Applicable

Safety and Effectiveness of eGERD Device to Reduce Gastroesophageal Reflux Disease (GERD) Symptoms

GERD (Gastroesophageal Reflux Disease)
Gerd Care Medical Ltd84 enrolled5 locationsNCT06613438
Recruiting
Not Applicable

Evaluating Medication Adherence of Patients With Gastroesophageal Reflux Disease With Support of the Smartphone Application GERDCare

GERD (Gastroesophageal Reflux Disease)
Institute of Gastroenterology and Hepatology, Vietnam380 enrolled1 locationNCT07125521
Recruiting

Indiana University Gastrointestinal Motility Diagnosis Registry

eosinophilic esophagitisConstipationGastroparesis+6 more
Indiana University5,000 enrolled1 locationNCT04506593
Recruiting
Phase 3

A Study Comparing the Effect and Safety of Linaprazan Glurate to Lansoprazole in Participants With Erosive Esophagitis (EE) Due to Gastroesophageal Reflux Disease (GERD)

GERD (Gastroesophageal Reflux Disease)
Cinclus Pharma Holding AB500 enrolled75 locationsNCT07037875
Recruiting
Early Phase 1

Development of a Preparation for Supportive Supplementation of Probiotics in Patients With Reflux

MicrobiomeReflux DiseaseProbiotics Supplement
University Hospital Olomouc50 enrolled1 locationNCT07600008
Recruiting
Not Applicable

Deprescribing Inappropriate Proton Pump Inhibitors

inappropriate prescribingProton Pump InhibitorsReflux Disease
University of Bern400 enrolled2 locationsNCT06129474
Recruiting
Phase 3

Domperidone in Treating Patients With Gastrointestinal Disorders

Nausea and VomitingGastroparesisDyspepsia+4 more
M.D. Anderson Cancer Center200 enrolled1 locationNCT01696734
Recruiting

Esophageal Cancer Risk Registry

Esophageal CancerEsophageal DiseasesEsophageal Achalasia+2 more
University of Pittsburgh7,000 enrolled1 locationNCT00260585
Recruiting
Not Applicable

Performance and Safety of Afluxin® in Patients With Gastroesophageal Reflux Disease

Gastroesophageal Reflux Disease (GERD)
Devintec Sagl208 enrolled7 locationsNCT06984484
Recruiting
Not Applicable

Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty Versus Esophagogastric Anastomosis for Gastric Cancer

Gastric CancerProximal Gastric AdenocarcinomaGastroesophageal Reflux Disease
Nanchong Central Hospital60 enrolled1 locationNCT05514769
Recruiting
Phase 2

A Study to Check the Safety of Dexlansoprazole and Learn if it Can Treat Symptomatic Nonerosive Gastroesophageal Reflux Disease in Children 2 to 11 Years Old

Gastroesophageal Reflux Disease (GERD)
Takeda70 enrolled33 locationsNCT02616302
Recruiting
Not Applicable

TLSA Versus TBSA Surgical Approach for Hiatal Hernia With Gastroesophageal Reflux Disease

GERD (Gastroesophageal Reflux Disease)Hernia, Hiatal
Beijing Friendship Hospital143 enrolled2 locationsNCT07252115
Recruiting
Not Applicable

Antireflux Suture In One Anastomsis Gastric Bypass

Vomiting, PostoperativeReflux Disease, Gastro-Esophageal
Khyber Teaching Hospital316 enrolled1 locationNCT07148492
Recruiting
Not Applicable

The Influence of Specialized Food Products Based on Ice-Cream on Esophageal Motility

GERD (Gastroesophageal Reflux Disease)Ineffective Esophageal Motility
Federal State Budgetary Scientific Institution30 enrolled1 locationNCT07121803
Recruiting
Phase 3

LINX vs Fundoplication

Gastro-oesophageal reflux disease
University of Oxford460 enrolled5 locationsNCT07093359
Recruiting
Not Applicable

Real-life Study of Changes of Gastroesophageal Reflux Disease Manifestations Due to Behavioural and Diet Adherence

Gastroesophageal Reflux DiseaseGERDGastroesophageal Erosion+3 more
Federal State Budgetary Scientific Institution150 enrolled1 locationNCT04255693