Reflux Disease Clinical Trials

28 recruitingLast updated: May 13, 2026

There are 28 actively recruiting reflux disease clinical trials across 21 countries. Studies span Not Applicable, Phase 3, Phase 4, Phase 2. Top locations include Bern, Switzerland, Moscow, Russia, Naples, Italy. Updated daily from ClinicalTrials.gov.


Reflux Disease Trials at a Glance

28 actively recruiting trials for reflux disease are listed on ClinicalTrialsFinder across 6 cities in 21 countries. The largest study group is Not Applicable with 14 trials, with the heaviest enrollment activity in Bern, Moscow, and Naples. Lead sponsors running reflux disease studies include Federal State Budgetary Scientific Institution "Federal Research Centre of Nutrition, Biotechnology, Cairo University, and Beijing Friendship Hospital.

Browse reflux disease trials by phase

Treatments under study

About Reflux Disease Clinical Trials

Looking for clinical trials for Reflux Disease? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Reflux Disease trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Reflux Disease clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 28 trials

Recruiting
Not Applicable

Safety and Effectiveness of eGERD Device to Reduce Gastroesophageal Reflux Disease (GERD) Symptoms

GERD (Gastroesophageal Reflux Disease)
Gerd Care Medical Ltd84 enrolled4 locationsNCT06613438
Recruiting
Phase 3

Domperidone in Treating Patients With Gastrointestinal Disorders

Nausea and VomitingGastroparesisDyspepsia+4 more
M.D. Anderson Cancer Center200 enrolled1 locationNCT01696734
Recruiting

Esophageal Cancer Risk Registry

Esophageal CancerEsophageal DiseasesEsophageal Achalasia+2 more
University of Pittsburgh7,000 enrolled1 locationNCT00260585
Recruiting
Not Applicable

Mechanistic and Clinical Outcomes of a Surgical Innovation Aimed at Minimizing GERD Associated With VSG (INNOVATE-VSG)

ObesityBariatric SurgeryGastroesophageal Reflux Disease+1 more
University of California, Irvine44 enrolled2 locationsNCT06783751
Recruiting
Not Applicable

Performance and Safety of Afluxin® in Patients With Gastroesophageal Reflux Disease

Gastroesophageal Reflux Disease (GERD)
Devintec Sagl208 enrolled7 locationsNCT06984484
Recruiting
Not Applicable

Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty Versus Esophagogastric Anastomosis for Gastric Cancer

Gastric CancerProximal Gastric AdenocarcinomaGastroesophageal Reflux Disease
Nanchong Central Hospital60 enrolled1 locationNCT05514769
Recruiting
Not Applicable

Evaluating Medication Adherence of Patients With Gastroesophageal Reflux Disease With Support of the Smartphone Application GERDCare

GERD (Gastroesophageal Reflux Disease)
Institute of Gastroenterology and Hepatology, Vietnam380 enrolled1 locationNCT07125521
Recruiting
Not Applicable

Deprescribing Inappropriate Proton Pump Inhibitors

inappropriate prescribingProton Pump InhibitorsReflux Disease
University of Bern400 enrolled2 locationsNCT06129474
Recruiting
Phase 2

A Study to Check the Safety of Dexlansoprazole and Learn if it Can Treat Symptomatic Nonerosive Gastroesophageal Reflux Disease in Children 2 to 11 Years Old

Gastroesophageal Reflux Disease (GERD)
Takeda70 enrolled33 locationsNCT02616302
Recruiting
Not Applicable

TLSA Versus TBSA Surgical Approach for Hiatal Hernia With Gastroesophageal Reflux Disease

GERD (Gastroesophageal Reflux Disease)Hernia, Hiatal
Beijing Friendship Hospital143 enrolled2 locationsNCT07252115
Recruiting
Not Applicable

Antireflux Suture In One Anastomsis Gastric Bypass

Vomiting, PostoperativeReflux Disease, Gastro-Esophageal
Khyber Teaching Hospital316 enrolled1 locationNCT07148492
Recruiting
Not Applicable

The Influence of Specialized Food Products Based on Ice-Cream on Esophageal Motility

GERD (Gastroesophageal Reflux Disease)Ineffective Esophageal Motility
Federal State Budgetary Scientific Institution "Federal Research Centre of Nutrition, Biotechnology30 enrolled1 locationNCT07121803
Recruiting
Phase 3

LINX vs Fundoplication

Gastro-oesophageal reflux disease
University of Oxford460 enrolled5 locationsNCT07093359
Recruiting
Not Applicable

Real-life Study of Changes of Gastroesophageal Reflux Disease Manifestations Due to Behavioural and Diet Adherence

Gastroesophageal Reflux DiseaseGERDGastroesophageal Erosion+3 more
Federal State Budgetary Scientific Institution "Federal Research Centre of Nutrition, Biotechnology150 enrolled1 locationNCT04255693
Recruiting
Phase 4

Clinical Trial for the Comparative Evaluation of Acid Suppression and Symptom Management of Gastroesophageal Reflux Disease With the Administration of Tegoprazan or Pantoprazole

Gastroesophageal Reflux Disease
Carnot Laboratories128 enrolled2 locationsNCT06991348
Recruiting

Normal Values of Ambulatory 24-hour Oesophageal pH-impedance Monitoring in an Indian Cohort of Participants

GERD (Gastroesophageal Reflux Disease)
Asian Institute of Gastroenterology, India50 enrolled1 locationNCT06928350
Recruiting

A Study of the Safety of Vonoprazan Exposure in Pregnant Women and Their Offspring

Helicobacter Pylori InfectionErosive EsophagitisSymptomatic Non-erosive Gastroesophageal Reflux Disease+1 more
Phathom Pharmaceuticals, Inc.728 enrolled1 locationNCT06660342
Recruiting
Not Applicable

Prospective Evaluation of Cornerstone Robotics Sentire Surgical System in Major Gastrointestinal and Urologic Surgery

Esophageal CancerGastric CancerColorectal Carcinoma+7 more
Chinese University of Hong Kong90 enrolled1 locationNCT06926374
Recruiting

Post-Market Registry for the Evaluation of RefluxStop in GERD Treatment

Gastroesophageal Reflux Disease (GERD)
Implantica CE Reflux Ltd.2,500 enrolled6 locationsNCT05870163
Recruiting
Phase 4

Clinical Study Evaluating The Role of Vonoprazan Versus Pantoprazole in Patients With Gastroesophageal Reflux Disease

Gastroesophageal Reflux Disease (GERD)
Tanta University44 enrolled1 locationNCT06564246