Regurgitation Clinical Trials

171 recruitingLast updated: May 21, 2026

There are 171 actively recruiting regurgitation clinical trials across 38 countries. Studies span Not Applicable, Phase 4, Phase 1, Phase 2. Top locations include New York, New York, United States, Cleveland, Ohio, United States, Atlanta, Georgia, United States. Updated daily from ClinicalTrials.gov.


Regurgitation Trials at a Glance

171 actively recruiting trials for regurgitation are listed on ClinicalTrialsFinder across 6 cities in 38 countries. The largest study group is Not Applicable with 89 trials, with the heaviest enrollment activity in New York, Cleveland, and Atlanta. Lead sponsors running regurgitation studies include Edwards Lifesciences, Abbott Medical Devices, and LMU Klinikum.

Browse regurgitation trials by phase

About Regurgitation Clinical Trials

Looking for clinical trials for Regurgitation? There are currently 3 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Regurgitation trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Regurgitation clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 171 trials

Recruiting
Not Applicable

ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™

Aortic Valve InsufficiencyAortic Insufficiencyaortic regurgitation
JenaValve Technology, Inc.1,016 enrolled24 locationsNCT06608823
Recruiting
Not Applicable

Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Mitral Valve Regurgitation
Medtronic Cardiovascular1,056 enrolled85 locationsNCT03242642
Recruiting
Not Applicable

Clinical Study of the inQB8 TTVR System (The MonarQ Study)

Tricuspid Valve Regurgitation
inQB8 Medical Technologies, LLC50 enrolled8 locationsNCT06611579
Recruiting

Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study

Tricuspid RegurgitationValvular Heart DiseaseMitral Regurgitation
Abbott Medical Devices550 enrolled17 locationsNCT04761120
Recruiting
Not Applicable

Early Mitral ValvE Repair Versus Watchful Waiting for Asymptomatic SEvere Degenerative Mitral Regurgitation

Degenerative Mitral Regurgitation (MR) Due to Leaflet Prolapse
Centre Hospitalier Universitaire, Amiens424 enrolled2 locationsNCT03389542
Recruiting
Not Applicable

EFS of the DUO System for Tricuspid Regurgitation

Tricuspid RegurgitationHeart Valve DiseasesTricuspid Valve Insufficiency+1 more
CroiValve Limited15 enrolled16 locationsNCT05913908
Recruiting

Abbott Cephea Mitral Valve Disease Registry

Mitral RegurgitationMitral StenosisMitral Valve Disease+4 more
Abbott Medical Devices1,000 enrolled22 locationsNCT07069673
Recruiting
Not Applicable

TARGET 2.0 Study: Safety and Performance of the Cardiovalve TR Replacement System

Tricuspid Regurgitation
Cardiovalve Ltd.150 enrolled1 locationNCT07334691
Recruiting

Patients With Severe TrIcuspid Regurgitation After triCvALve System Implantation

Severe Tricuspid Valve Regurgitation
Azienda Ospedaliero, Universitaria Pisana100 enrolled1 locationNCT05820516
Recruiting
Not Applicable

Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Tricuspid RegurgitationTricuspid Valve InsufficiencyTricuspid Valve Disease
Edwards Lifesciences1,270 enrolled79 locationsNCT04097145
Recruiting
Not Applicable

Harmony TPV EMEA PMS

Severe Pulmonary Valve Regurgitation
Medtronic Cardiovascular80 enrolled12 locationsNCT06906926
Recruiting
Not Applicable

TRICuspid Intervention and Invasive Hemodynamic Monitoring in Heart Failure

Heart Failure With Severe Tricuspid Regurgitation
LMU Klinikum45 enrolled2 locationsNCT07442903
Recruiting

CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry

Mitral RegurgitationMitral Valve DiseaseMitral Annular Calcification
Universitätsklinikum Hamburg-Eppendorf1,000 enrolled43 locationsNCT04688190
Recruiting
Not Applicable

J-Valve Transfemoral Pivotal Study

Aortic Valve RegurgitationAortic Valve Disease Mixed
JC Medical, Inc., an affiliate of Edwards Lifesciences LLC194 enrolled40 locationsNCT06455787
Recruiting
Not Applicable

Transcatheter Mitral Valve Repair for Inotrope Dependent Cardiogenic Shock

Cardiogenic ShockMitral Regurgitation
Ottawa Heart Institute Research Corporation144 enrolled4 locationsNCT05298124
Recruiting
Not Applicable

A Clinical Study of GeminiOne TEER System for the Treatment of Severe, Symptomatic MR.

Mitral Regurgitation
Sierra Valve LLC15 enrolled1 locationNCT07086534
Recruiting

Atrial Functional Mitral Regurgitation and Tricuspid Regurgitation

Atrial FibrillationFunctional Mitral RegurgitationFunctional Tricuspid Regurgitation
Barts & The London NHS Trust141 enrolled1 locationNCT05920824
Recruiting

DELINEATE-Prospective

Valvular Heart DiseaseValve Disease, AorticAortic Stenosis+3 more
Columbia University50 enrolled1 locationNCT07197736
Recruiting
Not Applicable

The TRICURE EFS Study

Cardiovascular DiseasesTricuspid Valve RegurgitationHeart Valve Diseases
TRiCares15 enrolled9 locationsNCT06506942
Recruiting
Not Applicable

The TRICURE EU Pivotal Study

Cardiovascular DiseasesHeart Valve DiseaseTricuspid Valve Regurgitation
TRiCares80 enrolled8 locationsNCT06581471