Regurgitation Clinical Trials

177 recruitingLast updated: July 25, 2026

There are 177 actively recruiting regurgitation clinical trials across 38 countries. Studies span Not Applicable, Phase 4, Phase 1, Phase 2. Top locations include New York, New York, United States, Cleveland, Ohio, United States, Los Angeles, California, United States. Updated daily from ClinicalTrials.gov.


Regurgitation Trials at a Glance

177 actively recruiting trials for regurgitation are listed on ClinicalTrialsFinder across 6 cities in 38 countries. The largest study group is Not Applicable with 92 trials, with the heaviest enrollment activity in New York, Cleveland, and Los Angeles. Lead sponsors running regurgitation studies include Abbott Medical Devices, Edwards Lifesciences, and LMU Klinikum.

Browse regurgitation trials by phase

Treatments under study

About Regurgitation Clinical Trials

Looking for clinical trials for Regurgitation? There are currently 3 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Regurgitation trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Regurgitation clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 177 trials

Recruiting
Not Applicable

The TRICURE EFS Study

Cardiovascular DiseasesTricuspid Valve RegurgitationHeart Valve Diseases
TRiCares15 enrolled10 locationsNCT06506942
Recruiting
Not Applicable

Laplace Early Feasibility Study - Canada

Tricuspid Regurgitation
Laplace Interventional, Inc15 enrolled3 locationsNCT07171060
Recruiting
Not Applicable

Early Feasibility Study (EFS) Laplace Transcatheter Tricuspid Valve Replacement (TTVR) System

Tricuspid Regurgitation
Laplace Interventional, Inc65 enrolled10 locationsNCT06183684
Recruiting

Atrial Functional Mitral Regurgitation and Tricuspid Regurgitation

Atrial FibrillationFunctional Mitral RegurgitationFunctional Tricuspid Regurgitation
Barts & The London NHS Trust60 enrolled1 locationNCT05920824
Recruiting
Not Applicable

Capstan Medical TMVR Study: FIH

Mitral Regurgitation
Capstan Medical10 enrolled3 locationsNCT06600191
Recruiting
Not Applicable

Harmony TPV EMEA PMS

Severe Pulmonary Valve Regurgitation
Medtronic Cardiovascular80 enrolled12 locationsNCT06906926
Recruiting
Not Applicable

New Topical tReatment Options for Symptomatic patiEnts With Nonerosive gastroesophageaL Reflux dIsease (The RELIEF Trial)

GERD (Gastroesophageal Reflux Disease)NERDRegurgitation, Gastric+1 more
Cellmedis50 enrolled1 locationNCT07624383
Recruiting
Phase 1

A Clinical Study Evaluating the Replacement of the Native Mitral Valve Using the ReValve System

Mitral Regurgitation
ReValve Solutions Inc.20 enrolled3 locationsNCT07450911
Recruiting
Not Applicable

Cephea Early Feasibility Study

Mitral Regurgitation
Abbott Medical Devices50 enrolled22 locationsNCT05061004
Recruiting
Not Applicable

ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™

Aortic Valve InsufficiencyAortic Insufficiencyaortic regurgitation
JenaValve Technology, Inc.1,016 enrolled29 locationsNCT06608823
Recruiting
Not Applicable

A Study to Evaluate the Safety and Performance of TruGamma System for Tricuspid Replacement

Tricuspid Valve RegurgitationTricuspid Valve InsufficiencyTricuspid Valve Disease
Jiangsu Trulive Medical Co., Ltd180 enrolled1 locationNCT07691307
Recruiting
Not Applicable

The Feasibility Study of Polymer Artificial Heart Valve for the Treatment the Mitral Valve Disease.

Severe Mitral Valve Regurgitation, Severe Mitral Valve Stenosis
Shanghai HeartEpoch Medical Technology Co., Ltd10 enrolled1 locationNCT07243184
Recruiting
Not Applicable

Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Tricuspid RegurgitationTricuspid Valve InsufficiencyTricuspid Valve Disease
Edwards Lifesciences1,270 enrolled79 locationsNCT04097145
Recruiting
Not Applicable

Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - APOLLO-EU Trial

Mitral Regurgitation
Medtronic Cardiovascular400 enrolled37 locationsNCT05496998
Recruiting

A Post-Market Assessment of the Safety and Performance of the TriClip™ System

Tricuspid Regurgitation (TR)
Abbott Medical Devices1,000 enrolled4 locationsNCT07586995
Recruiting
Not Applicable

Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Mitral Valve Regurgitation
Medtronic Cardiovascular1,056 enrolled85 locationsNCT03242642
Recruiting
Not Applicable

TTVR Early Feasibility Study

Tricuspid Regurgitation
Medtronic Cardiovascular150 enrolled20 locationsNCT04433065
Recruiting
Not Applicable

The CardioClip Study

Heart Failure With Reduced Ejection FractionMitral Regurgitation
Columbia University60 enrolled1 locationNCT06241430
Recruiting

Abbott Cephea Mitral Valve Disease Registry

Mitral RegurgitationMitral StenosisMitral Valve Disease+4 more
Abbott Medical Devices1,000 enrolled23 locationsNCT07069673
Recruiting

STS/ACC TVT Registry Mitral Module

Mitral Valve Regurgitation
American College of Cardiology4,000 enrolled1 locationNCT02245763