Phase 1 Solid Tumor, Adult Clinical Trials
74 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 74 trials
Recruiting
Phase 1Phase 2
A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression
Colorectal, CancerOvarian CancerLung Cancer+17 more
A2 Biotherapeutics Inc.474 enrolled12 locationsNCT06051695
Recruiting
Phase 1Phase 2
First-in-human Study of DB-1419 for Advanced/Metastatic Solid Tumors
Solid Tumor, Adult
DualityBio Inc.360 enrolled36 locationsNCT06554795
Recruiting
Phase 1
BBO-11818 in Adult Subjects With KRAS Mutant Cancer
Non-small Cell Lung CancerNSCLCMetastatic Pancreatic Ductal Adenocarcinoma+11 more
TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)665 enrolled17 locationsNCT06917079
Recruiting
Phase 1
Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
Endometrial CancerColorectal CarcinomaNon-small Cell Lung Cancer+3 more
AstraZeneca108 enrolled18 locationsNCT06218914
Recruiting
Phase 1Phase 2
A Study to Determine the Effect of CT3001 in Patients With Advanced Solid Tumors
Colorectal, CancerPancreatic Ductal AdenocarcinomaSolid Tumor, Adult
Crossignal Therapeutics, Inc.78 enrolled1 locationNCT06598007
Recruiting
Phase 1Phase 2
A Study of ATTR-01 in Participants With Select Epithelial Solid Tumours
Solid Tumor, Adult
Accession Therapeutics Limited72 enrolled8 locationsNCT06977737
Recruiting
Phase 1
First In Human Study of CX-2051 in Advanced Solid Tumors
Solid Tumor, Adult
CytomX Therapeutics160 enrolled7 locationsNCT06265688
Recruiting
Phase 1
First In Human Study of CX-801 in Advanced Solid Tumors
Solid Tumor, Adult
CytomX Therapeutics121 enrolled3 locationsNCT06462794
Recruiting
Phase 1Phase 2
ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors
CancerSolid Tumor, AdultRefractory Cancer+1 more
Immatics US, Inc.375 enrolled21 locationsNCT03686124
Recruiting
Phase 1Phase 2
COAST Therapy in Advanced Solid Tumors and Prostate Cancer
Solid Tumor, AdultProstate Cancer Recurrent
Medical University of South Carolina76 enrolled1 locationNCT05036226
Recruiting
Phase 1Phase 2
GT201 Injection For The Treatment Of Advanced Solid Tumors
Solid Tumor, Adult
Grit Biotechnology18 enrolled4 locationsNCT06144671
Recruiting
Phase 1Phase 2
A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
Colorectal, CancerNon-small Cell Lung CancerPancreatic Ductal Adenocarcinoma+2 more
Verastem, Inc.295 enrolled14 locationsNCT07020221
Recruiting
Phase 1
A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors
Triple-Negative Breast CancerGastric CancerOvarian Cancer+25 more
NiKang Therapeutics, Inc.150 enrolled19 locationsNCT06586957
Recruiting
Phase 1Phase 2
Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated Ca
Solid Tumor, Adult
Virginia Commonwealth University83 enrolled1 locationNCT03919292
Recruiting
Phase 1
A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors
MelanomaNSCLCSolid Tumor, Adult+6 more
Nested Therapeutics, Inc230 enrolled23 locationsNCT06326411
Recruiting
Phase 1Phase 2
A Study of BI-1206 in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors
Solid Tumor, Adult
BioInvent International AB197 enrolled25 locationsNCT04219254
Recruiting
Phase 1
Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors
Metastatic Breast CancerAdvanced Breast CancerMetastatic Lung Cancer+8 more
TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)392 enrolled36 locationsNCT06625775
Recruiting
Phase 1
A Study of HQP1351 in Patients With GIST or Other Solid Tumors
Solid Tumor, AdultGastrointestinal Stromal Tumor (GIST)
Ascentage Pharma Group Inc.100 enrolled6 locationsNCT03594422
Recruiting
Phase 1
A Study of VET3-TGI in Patients With Solid Tumors
Cervical CancerNon-small Cell Lung CancerHead and Neck Squamous Cell Carcinoma+10 more
KaliVir Immunotherapeutics60 enrolled7 locationsNCT06444815
Recruiting
Phase 1Phase 2
Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors
NSCLCSolid Tumor, AdultMesothelioma
Vivace Therapeutics, Inc434 enrolled12 locationsNCT04665206