Phase 1 Solid Tumor, Adult Clinical Trials
68 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 68 trials
Recruiting
Phase 1
Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
Endometrial CancerColorectal CarcinomaNon-small Cell Lung Cancer+3 more
AstraZeneca108 enrolled18 locationsNCT06218914
Recruiting
Phase 1Phase 2
GT201 Injection For The Treatment Of Advanced Solid Tumors
Solid Tumor, Adult
Grit Biotechnology18 enrolled4 locationsNCT06144671
Recruiting
Phase 1
A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors
Ovarian CancerOvarian CarcinomaAdvanced Solid Tumor+8 more
NiKang Therapeutics, Inc.150 enrolled19 locationsNCT06586957
Recruiting
Phase 1Phase 2
Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated Ca
Solid Tumor, Adult
Virginia Commonwealth University83 enrolled1 locationNCT03919292
Recruiting
Phase 1Phase 2
A Study of BI-1206 in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors
Solid Tumor, Adult
BioInvent International AB197 enrolled25 locationsNCT04219254
Recruiting
Phase 1Phase 2
ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors
CancerSolid Tumor, AdultRefractory Cancer+1 more
Immatics US, Inc.375 enrolled21 locationsNCT03686124
Recruiting
Phase 1
Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors
Metastatic Breast CancerAdvanced Breast CancerMetastatic Lung Cancer+6 more
TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)392 enrolled36 locationsNCT06625775
Recruiting
Phase 1
A Study of HQP1351 in Patients With GIST or Other Solid Tumors
Solid Tumor, AdultGastrointestinal Stromal Tumor (GIST)
Ascentage Pharma Group Inc.100 enrolled6 locationsNCT03594422
Recruiting
Phase 1
A Study of VET3-TGI in Patients With Solid Tumors
Cervical CancerNon-small Cell Lung CancerHead and Neck Squamous Cell Carcinoma+10 more
KaliVir Immunotherapeutics60 enrolled7 locationsNCT06444815
Recruiting
Phase 1Phase 2
Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors
NSCLCSolid Tumor, AdultMesothelioma
Vivace Therapeutics, Inc434 enrolled12 locationsNCT04665206
Recruiting
Phase 1Phase 2
First-in-human Study of DB-1419 for Advanced/Metastatic Solid Tumors
Solid Tumor, Adult
DualityBio Inc.360 enrolled36 locationsNCT06554795
Recruiting
Phase 1Phase 2
COAST Therapy in Advanced Solid Tumors and Prostate Cancer
Solid Tumor, AdultProstate Cancer Recurrent
Medical University of South Carolina76 enrolled1 locationNCT05036226
Recruiting
Phase 1
First In Human Study of CX-2051 in Advanced Solid Tumors
Solid Tumor, Adult
CytomX Therapeutics160 enrolled5 locationsNCT06265688
Recruiting
Phase 1Phase 2
A Study of ATTR-01 in Participants With Select Epithelial Solid Tumours
Solid Tumor, Adult
Accession Therapeutics Limited72 enrolled7 locationsNCT06977737
Recruiting
Phase 1
First In Human Study of CX-801 in Advanced Solid Tumors
Solid Tumor, Adult
CytomX Therapeutics121 enrolled2 locationsNCT06462794
Recruiting
Phase 1Phase 2
Study of AK119 Combined With AK112 in Patients With Advanced Solid Tumors
Solid Tumor, Adult
Akeso87 enrolled1 locationNCT05689853
Recruiting
Phase 1Phase 2
A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors
Metastatic Solid TumorSolid Tumor, AdultUnresectable Solid Tumor+1 more
Frontier Medicines Corporation403 enrolled26 locationsNCT06244771
Recruiting
Phase 1
An Open-Label Study of INV-1120 as a Single Agent and in Combination With Pembrolizumab in Adult Patients With Advanced Solid Tumors
CancerSolid Tumor, Adult
Shenzhen Ionova Life Sciences Co., Ltd.78 enrolled3 locationsNCT04443088
Recruiting
Phase 1Phase 2
64Cu-GRIP B in Patients With Advanced Malignancies
Prostate CancerAdvanced Solid TumorSolid Tumor, Adult+3 more
Rahul Aggarwal91 enrolled1 locationNCT05888532
Recruiting
Phase 1
Advanced or Recurrent Solid Tumors Treated With SHetA2
Solid Tumor, Adult
University of Oklahoma50 enrolled1 locationNCT04928508