Spasticity Clinical Trials

22 recruiting

Spasticity Trials at a Glance

53 actively recruiting trials for spasticity are listed on ClinicalTrialsFinder across 6 cities in 31 countries. The largest study group is Not Applicable with 29 trials, with the heaviest enrollment activity in Dallas, Boston, and Atlanta. Lead sponsors running spasticity studies include Eva Ponten, Chongqing Claruvis Pharmaceutical Co., Ltd., and Ipsen.

Browse spasticity trials by phase

Treatments under study

About Spasticity Clinical Trials

Looking for clinical trials for Spasticity? There are currently 22 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Spasticity trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Spasticity clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 53 trials

Recruiting
Not Applicable

Pilot Study on Muscle, Tendon, and Neural Changes Post-Botulinum Toxin Injections in Post-stroke Spastic Equinovarus

StrokeSpasticityEquinovarus Foot
Universitaire Ziekenhuizen KU Leuven12 enrolled1 locationNCT06767631
Recruiting
Not Applicable

Cryoneurolysis for Spasticity Treatment: Long-term Clinical Outcomes and Mechanisms in the Central Nervous System

Spasticity as Sequela of Stroke
Sue Peters25 enrolled1 locationNCT06958289
Recruiting
Not Applicable

Does ESWT With BoNTA Treatment Improve Outcomes When Compared to Standard Management for Upper Limb Spasticity Patient.

Spasticity, Muscle
University of Alberta40 enrolled1 locationNCT05226637
Recruiting
Not Applicable

Study to Assess the Efficacy and Safety of Iovera®° System in Subjects With Upper Extremity Spasticity

Spasticity, Cerebral or Spinal Condition
Pacira Pharmaceuticals, Inc132 enrolled18 locationsNCT06340451
Recruiting
Not Applicable

Spinal Cord Stimulation for Children With Cerebral Palsy

Cerebral PalsySpasticity
Martin Piazza30 enrolled1 locationNCT07516067
Recruiting
Phase 1Phase 2

A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.

Spasticity
Ipsen240 enrolled81 locationsNCT04752774
Recruiting
Phase 3

A Study on Recombinant Botulinum Toxin Type A (YY001) for Injection in Multiple Treatments of Adult Upper Limb Spasticity

Upper Limb Spasticity
Chongqing Claruvis Pharmaceutical Co., Ltd.300 enrolled16 locationsNCT07478822
Recruiting

Classification of Upper and Lower Limb Spasticity Patterns and Their Impact on Quality of Life in Patients With Multiple Sclerosis

Multiple SclerosisSpasticitySpasticity With Multiple Sclerosis
Marmara University75 enrolled1 locationNCT07466823
Recruiting
Phase 1

Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury

Spinal Cord InjurySpasticityShockwave Therapy
Kessler Foundation12 enrolled1 locationNCT07501429
Recruiting

Neurosurgical Outcome Network

Trigeminal NeuralgiaHydrocephalusSubarachnoid Hemorrhage+14 more
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta4,500 enrolled27 locationsNCT06724029
Recruiting
Phase 2

A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity

Multiple Sclerosis Spasticity
Celgene200 enrolled53 locationsNCT06782490
Recruiting
Not Applicable

The Effectiveness of Different Pulse Duration of NMES in Patients With Pyramidal Tract-related Spasticity Measured by Neurophysiological Tools

Pyramidal Tract-related SpasticityUpper Motor Neuron Lesion
University of West Attica45 enrolled1 locationNCT07321158
Recruiting
Not Applicable

Impact of rTMS Combined With Neurorehabilitation on Lower Extremity Motor Function and Spasticity in Children With Spastic Diplegic Cerebral Palsy

Cerebral Palsy (CP)Transcranial Magnetic StimilationDiplegic Cerebral Palsy With Spasticity+1 more
Ankara City Hospital Bilkent20 enrolled1 locationNCT07488429
Recruiting
Not Applicable

Upper Limb Nerve Cryoneurolysis is Non Inferior to the Usual Care and Has Therapeutic Add Value in Dealing With Shoulder Pain and Functional Problems Caused by Spasticity and Motor Impairment

Traumatic Brain InjuryStrokeMultiple Sclerosis+5 more
Centre National de Rééducation Fonctionnelle et de Réadaptation50 enrolled1 locationNCT06782464
Recruiting

Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)

Movement DisordersMotor Neuron DiseaseHereditary Spastic Paraplegia+3 more
Boston Children's Hospital200 enrolled1 locationNCT05354622
Recruiting

A Study to Estimate How Often Post-stroke Spasticity Occurs and to Provide a Standard Guideline on the Best Way to Monitor Its Development

Spasticity as Sequela of Stroke
Ipsen1,051 enrolled59 locationsNCT06055725
Recruiting
Not Applicable

Evaluation of Percutaneous Cryoneurotomy Compared to Surgical Open Neurotomy for the Management of Equinovarus Foot Deformity in Patients With Refractory Lower Limb Spasticity After Stroke

StrokeEquinovarus FootRefractory Lower Limb Spasticity
Poitiers University Hospital114 enrolled7 locationsNCT06726434
Recruiting
Not Applicable

Leg Stretching Using an Exoskeleton on Demand for People With Spasticity

Movement DisordersSpinal Cord InjurySpasticity
VA Office of Research and Development10 enrolled1 locationNCT05926596
Recruiting
Not Applicable

At Home Use of Stimulation Suits for Managing MS Symptoms

Multiple SclerosisSpasticityAtaxia - Other+5 more
Daphne Kos70 enrolled2 locationsNCT07202195
Recruiting

Ultrasonographic Assessment of Muscle Morphology, Function, and Clinical Findings in Spastic Cerebral Palsy

Muscle SpasticityGait Disorders, NeurologicCerebral Palsy, Spastic
Kocaeli University36 enrolled1 locationNCT07118228