Stage IIIC Clinical Trials

63 recruitingLast updated: June 20, 2026

There are 63 actively recruiting stage iiic clinical trials across 10 countries. Studies span Phase 2, Not Applicable, Phase 1, Phase 3, Early Phase 1, Phase 4. Top locations include Houston, Texas, United States, Los Angeles, California, United States, Columbus, Ohio, United States. Updated daily from ClinicalTrials.gov.


Stage IIIC Trials at a Glance

63 actively recruiting trials for stage iiic are listed on ClinicalTrialsFinder across 6 cities in 10 countries. The largest study group is Phase 2 with 19 trials, with the heaviest enrollment activity in Houston, Los Angeles, and Columbus. Lead sponsors running stage iiic studies include M.D. Anderson Cancer Center, Jonsson Comprehensive Cancer Center, and Emory University.

Browse stage iiic trials by phase

Treatments under study

About Stage IIIC Clinical Trials

Looking for clinical trials for Stage IIIC? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Stage IIIC trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Stage IIIC clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 63 trials

Recruiting
Phase 3

Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial

Estrogen Receptor-Positive Breast CarcinomaHER2-Negative Breast CarcinomaAnatomic Stage II Breast Cancer AJCC v8+2 more
National Cancer Institute (NCI)1,978 enrolled22 locationsNCT07391774
Recruiting
Phase 3

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

Stage IIIB Lung Cancer AJCC v8Stage IIIC Lung Cancer AJCC v8Stage IV Lung Cancer AJCC v8+1 more
National Cancer Institute (NCI)304 enrolled319 locationsNCT06096844
Recruiting
Phase 3

Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

Stage IIIA Cervical Cancer FIGO 2018Stage IIIB Cervical Cancer FIGO 2018Locally Advanced Cervical Adenocarcinoma+5 more
National Cancer Institute (NCI)336 enrolled271 locationsNCT07061977
Recruiting
Phase 2

Neoadjuvant Botensilimab and Balstilimab for the Treatment of Advanced Resectable Colorectal Cancer NEST3

Advanced Colorectal AdenocarcinomaStage IIB Rectal Cancer AJCC v8Stage IIC Rectal Cancer AJCC v8+10 more
City of Hope Medical Center100 enrolled11 locationsNCT07595874
Recruiting
Phase 2

SX-682 With Pembrolizumab for the Treatment of Metastatic or Recurrent Stage IIIC or IV Non-Small Cell Lung Cancer

Metastatic Lung Non-Small Cell CarcinomaStage IIIC Lung Cancer AJCC v8Stage IV Lung Cancer AJCC v8+1 more
University of Washington30 enrolled1 locationNCT05570825
Recruiting
Phase 2

Canakinumab for the Prevention of Lung Cancer, the Can-Prevent-Lung Trial

Lung CarcinomaStage III Lung Cancer AJCC v8Stage IIIA Lung Cancer AJCC v8+10 more
M.D. Anderson Cancer Center50 enrolled1 locationNCT04789681
Recruiting
Phase 2

Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors

Anatomic Stage IV Breast Cancer AJCC v8Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8+26 more
M.D. Anderson Cancer Center50 enrolled1 locationNCT04771520
Recruiting
Phase 1

IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors

Clinical Stage III Cutaneous Melanoma AJCC v8Clinical Stage IV Cutaneous Melanoma AJCC v8Stage IIIA Uterine Corpus Cancer AJCC v8+35 more
M.D. Anderson Cancer Center54 enrolled1 locationNCT05039801
Recruiting
Not Applicable

Stereotactic Body Radiotherapy Boost Versus Simultaneous Integrated Boost to Pelvic Nodes Among Patients Receiving Radical Chemoradiation in Carcinoma Cervix

Stage IIIC
All India Institute of Medical Sciences150 enrolled3 locationsNCT07585929
Recruiting

Minimal Residual Disease Assessment in Patients With Colorectal Cancer, the MiRDA-C Study

Stage I Colorectal Cancer AJCC v8Stage II Colorectal Cancer AJCC v8Stage IIA Colorectal Cancer AJCC v8+11 more
M.D. Anderson Cancer Center1,000 enrolled10 locationsNCT04739072
Recruiting

Social Health, Activity Behaviors, and Quality of Life Among Young Adult Cancer Survivors

Malignant Brain NeoplasmMalignant Solid NeoplasmMalignant Testicular Neoplasm+97 more
University of Southern California250 enrolled2 locationsNCT07259304
Recruiting
Early Phase 1

Active Surveillance and Chemotherapy Before Surgery in Treating Participants With Stage II-III Rectal Cancer

Rectal AdenocarcinomaStage II Rectal Cancer AJCC v8Stage III Rectal Cancer AJCC v8+6 more
M.D. Anderson Cancer Center120 enrolled1 locationNCT03594630
Recruiting
Phase 1

Nelfinavir, Cisplatin, and External Beam Radiation Therapy for the Treatment of Locally Advanced Vulvar Cancer That Cannot Be Removed by Surgery

Stage II Vulvar Cancer AJCC v8Stage III Vulvar Cancer AJCC v8Stage IIIA Vulvar Cancer AJCC v8+3 more
M.D. Anderson Cancer Center25 enrolled1 locationNCT04169763
Recruiting
Phase 2

Androgen Ablation Therapy With or Without Niraparib After Radiation Therapy for the Treatment of High-Risk Localized or Locally Advanced Prostate Cancer

Prostate CarcinomaStage III Prostate Cancer AJCC v8Stage IVA Prostate Cancer AJCC v8+4 more
M.D. Anderson Cancer Center200 enrolled1 locationNCT04947254
Recruiting

Extending Prostate Genetic Awareness, Navigation, and Delivery: The EXPAND Network

Metastatic Prostate CarcinomaStage IV Prostate Cancer AJCC v8Stage IIIB Prostate Cancer AJCC v8+1 more
Thomas Jefferson University30 enrolled1 locationNCT05627219
Recruiting
Phase 3

Testing Laser Therapy for Treatment of Vaginal Dryness in Survivors of Breast Cancer, The Revitalize Trial

Anatomic Stage II Breast Cancer AJCC v8Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage 0 Breast Cancer AJCC v8+9 more
Alliance for Clinical Trials in Oncology250 enrolled2 locationsNCT05379153
Recruiting
Not Applicable

Nutrition and Exercise Interventions for Androgen Deprivation Therapy-Induced Obese Frailty in Elderly and Non-Elderly Survivors of Advanced Prostate Cancer

ObesityProstate AdenocarcinomaCancer Survivor+17 more
Roswell Park Cancer Institute50 enrolled1 locationNCT03880422
Recruiting
Phase 1

Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer

Locally Advanced Gastroesophageal Junction AdenocarcinomaMetastatic Gastroesophageal Junction AdenocarcinomaStage IV Colorectal Cancer AJCC v8+26 more
Roswell Park Cancer Institute45 enrolled1 locationNCT04511039
Recruiting
Phase 2

Neoadjuvant SBRT Followed by Sintilimab Plus Chemotherapy for N3-Positive NSCLC

Locally Advanced Non-Small Cell Lung CancerStage IIIb Non-small Cell Lung CancerStage IIIC Non-Small Cell Lung Cancer
Yang Hong28 enrolled1 locationNCT07309952
Recruiting
Not Applicable

Decision Making Tool in Supporting Decision Making in Contralateral Prophylactic Mastectomy in Patients With Newly Diagnosed Breast Cancer

Anatomic Stage II Breast Cancer AJCC v8Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage I Breast Cancer AJCC v8+20 more
M.D. Anderson Cancer Center15 enrolled1 locationNCT02918474